Cyclic AMP Signaling in Biliary Proliferation: A Possible Target for Cholangiocarcinoma Treatment?
Cells, 2021 Cholangiocarcinoma is a lethal disease with scarce response to current systemic therapy. The rare occurrence and large heterogeneity of this cancer, together with poor knowledge of its molecular mechanisms, are elements contributing to the difficulties ...
Leonardo Baiocchi +11 more
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Type IV Pilus Secretins Have Extracellular C Termini
mBio, 2015 Type IV pili (T4Ps) are surface appendages used by Gram-negative and Gram-positive pathogens for motility and attachment to epithelial surfaces. In Gram-negative bacteria, such as the important pediatric pathogen enteropathogenic Escherichia coli (EPEC),
Joshua A. Lieberman +4 more
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Secretin Receptor as a Target in Gastrointestinal Cancer: Expression Analysis and Ligand Development
Biomedicines, 2022 Secretin was originally discovered as a gastrointestinal peptide that stimulates fluid secretion from the pancreas and liver and delays gastric emptying.
Anja Klussmeier +4 more
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Staging chronic pancreatitis with exocrine function tests: Are we better? [PDF]
, 2017 Chronic pancreatitis (CP) is an inflammatory disease of the pancreas evolving in progressive fibrotic disruption of the gland with exocrine and endocrine pancreatic insufficiency.
MOLETTA, LUCIA, SPERTI, COSIMO
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The role of epidermal growth factor-like module containing mucin-like hormone receptor 2 in human cancers. [PDF]
, 2014 G-protein coupled receptors (GPCRs) are among the most diverse and ubiquitous proteins in all of biology. The epidermal growth factor-seven span transmembrane (EGF-TM7) subfamily of adhesion GPCRs is a small subset whose members are mainly expressed on ...
Bloch, Orin +8 more
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Effect of Intraduodenal Bile and Na-Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Secretin, Pancreatic Polypeptide, and Gastrin in Man [PDF]
, 1990 The effect of intraduodenally administered cattle bile (CB) and Na-taurodeoxycholate (TDC) on basal pancreatic secretion and plasma levels of secretin, pancreatic polypeptide (PP), and gastrin were investigated on two separate days in 10 fasting ...
A. Scharl +46 more
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mBio, 2017 Sophisticated nanomachines are used by bacteria for protein secretion. In Gram-negative bacteria, the type 2 secretion system (T2SS) is composed of a pseudopilus assembly platform in the inner membrane and a secretin complex in the outer membrane.
Iain D. Hay +2 more
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Secretin attenuates the hereditary repetitive hyperactive movements in a mouse model [PDF]
, 2011 It was previously demonstrated that secretin influenced the behavior of rats investigated by open-field test. In the present experiment, we have compared the effect of intracerebroventricular administration of 2 mug of secretin on the behavior of ...
Dochnal Roberta +7 more
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The serendipitous origin of chordate secretin peptide family members
BMC Evolutionary Biology, 2010 Background The secretin family is a pleotropic group of brain-gut peptides with affinity for class 2 G-protein coupled receptors (secretin family GPCRs) proposed to have emerged early in the metazoan radiation via gene or genome duplications.
Gomes Ana S +3 more
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Spatial intensity distribution analysis: studies of G Protein-coupled receptor oligomerization [PDF]
, 2018 Spatial intensity distribution analysis (SpIDA) is a recently developed approach for determining quaternary structure information on fluorophore-labelled proteins of interest in situ. It can be applied to live or fixed cells and native tissue.
Marsango, Sara +3 more
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