Results 41 to 50 of about 34,649 (253)

Staging chronic pancreatitis with exocrine function tests: Are we better? [PDF]

, 2017
Chronic pancreatitis (CP) is an inflammatory disease of the pancreas evolving in progressive fibrotic disruption of the gland with exocrine and endocrine pancreatic insufficiency.
MOLETTA, LUCIA, SPERTI, COSIMO
core   +1 more source

Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early‐stage primary biliary cholangitis

The FASEB Journal, 2019
Primary biliary cholangitis (PBC) primarily targets cholangiocytes and is characterized by liver fibrosis and biliary proliferation. Activation of the secretin (Sct)/secretin receptor (SR) axis, expressed only by cholangiocytes, increases biliary ...
Lindsey Kennedy, H. Francis, P. Invernizzi, J. Venter, Nan Wu, M. Carbone, M. Eric Gershwin, F. Bernuzzi, A. Franchitto, D. Alvaro, M. Marzioni, P. Onori, E. Gaudio, A. Sybenga, L. Fabris, F. Meng, S. Glaser, G. Alpini   +17 more
semanticscholar   +1 more source

Effect of Intraduodenal Bile and Na-Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Secretin, Pancreatic Polypeptide, and Gastrin in Man [PDF]

, 1990
The effect of intraduodenally administered cattle bile (CB) and Na-taurodeoxycholate (TDC) on basal pancreatic secretion and plasma levels of secretin, pancreatic polypeptide (PP), and gastrin were investigated on two separate days in 10 fasting ...
A. Scharl, Aronchick C A, Bjornsson O G, Bondesen S, Burhol P G, Burhol P G, Burhol P G, Carey M C, Davies H A, Dragstedt L R, F. Fiedler, Fahrenkrug J, Flaten O, Florholmen J, Forell M M, Forell M M, Greenberg G R, Gries E, Grossman M I, Hanssen L E, Hartmann W, Hunter W M, I. Hempen, J. Teufel, Jorde R, Konturek S J, Lehnert P, Londong W, Lonovics J, Malagelada J-R., Malagelada J-R., Miyasaka K, Miyazaki K, Moreland H J, Morris B J, Osnes M, Osnes M, Otte M, P. G. Burhol, P. Lehnert, Petersen H, R. L. Riepl, Scatchard G, Schaffalitzky de Muckadell O B, Schwartz T W, Thomas J E, Wormsley K G   +46 more
core   +1 more source

Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin

Nature Communications, 2018
The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine essential for the virulence of many disease causing Gram-negative bacteria.
J. Hu, L. Worrall, Cynthia Hong, M. Vuckovic, C. Atkinson, N. Caveney, Z. Yu, N. Strynadka   +7 more
semanticscholar   +1 more source

Secretin attenuates the hereditary repetitive hyperactive movements in a mouse model [PDF]

, 2011
It was previously demonstrated that secretin influenced the behavior of rats investigated by open-field test. In the present experiment, we have compared the effect of intracerebroventricular administration of 2 mug of secretin on the behavior of ...
Dochnal Roberta, Heinzlmann Andrea, Kiss Gusztáv, Köves Katalin, Manczinger Máté, Pál Ágnes, Sipos Ildikó, Szabó Gyula   +7 more
core   +1 more source

Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2−/− mice by diminishing senescence of cholangiocytes

Laboratory Investigation, 2018
Secretin receptor (SR), only expressed by cholangiocytes, plays a key role in the regulation of biliary damage and liver fibrosis. The aim of this study was to determine the effects of genetic depletion of SR in Mdr2−/− mice on intrahepatic biliary mass,
Tianhao Zhou, Nan Wu, F. Meng, J. Venter, Thao Giang, H. Francis, Konstantina Kyritsi, Chaodong Wu, A. Franchitto, D. Alvaro, M. Marzioni, P. Onori, R. Mancinelli, E. Gaudio, S. Glaser, G. Alpini   +15 more
semanticscholar   +1 more source

Structural Basis of Type 2 Secretion System Engagement between the Inner and Outer Bacterial Membranes

mBio, 2017
Sophisticated nanomachines are used by bacteria for protein secretion. In Gram-negative bacteria, the type 2 secretion system (T2SS) is composed of a pseudopilus assembly platform in the inner membrane and a secretin complex in the outer membrane.
Iain D. Hay, Matthew J. Belousoff, Trevor Lithgow   +2 more
doaj   +1 more source

Peribiliary glands are key in regeneration of the human biliary epithelium after severe bile duct injury [PDF]

, 2019
Peribiliary glands (PBG) are a source of stem/progenitor cells organized in a cellular network encircling large bile ducts. Severe cholangiopathy with loss of luminal biliary epithelium has been proposed to activate PBG, resulting in cell proliferation ...
Carpino, Guido, de Jong, Iris E M, Gaudio, Eugenio, Gouw, Annette S H, Iswandana, Raditya, Lisman, Ton, Matton, Alix P M, Olinga, Peter, Oosterhuis, Dorenda, Overi, Diletta, Porte, Robert J, Suriguga, Su, van Haaften, Wouter T, van Praagh, Jasper B, van Wijk, Louise A, Wiersema-Buist, Janneke   +15 more
core   +3 more sources

The serendipitous origin of chordate secretin peptide family members

BMC Evolutionary Biology, 2010
Background The secretin family is a pleotropic group of brain-gut peptides with affinity for class 2 G-protein coupled receptors (secretin family GPCRs) proposed to have emerged early in the metazoan radiation via gene or genome duplications.
Gomes Ana S, Vieira Florbela A, Cardoso João CR, Power Deborah M   +3 more
doaj   +1 more source

In situ imaging of bacterial outer membrane projections and associated protein complexes using electron cryo-tomography

eLife, 2021
The ability to produce outer membrane projections in the form of tubular membrane extensions (MEs) and membrane vesicles (MVs) is a widespread phenomenon among diderm bacteria.
Mohammed Kaplan, Georges Chreifi, Lauren Ann Metskas, Janine Liedtke, Cecily R Wood, Catherine M Oikonomou, William J Nicolas, Poorna Subramanian, Lori A Zacharoff, Yuhang Wang, Yi-Wei Chang, Morgan Beeby, Megan J Dobro, Yongtao Zhu, Mark J McBride, Ariane Briegel, Carrie L Shaffer, Grant J Jensen   +17 more
doaj   +1 more source