Results 51 to 60 of about 2,034,530 (343)

The pathophysiology of intestinal lipoprotein production

Frontiers in Physiology, 2015
Intestinal lipoprotein production is a multistep process, essential for the absorption of dietary fats and fat-soluble vitamins. Chylomicron assembly begins in the endoplasmic reticulum with the formation of primordial, phospholipids-rich particles that ...
Antonina eGiammanco, Angelo Baldassare Cefalu', Davide eNoto, Maurizio eAverna   +3 more
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Transport and recycling of radiocesium in the alimentary tract of reindeer

Rangifer, 1990
Transport of radiocesium between the body pools and the alimentary tract was studied in 7 reindeer calves. Comparisons were made between reindeer receiving the Cs- binder Prussian blue (Ammon-ium-ironhexacyanoferrate) and untreated animals.
Hans Staaland, Knut Hove, Øyvind Pedersen   +2 more
doaj   +1 more source

Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion

Nature Communications, 2019
Extracellular phosphate regulates its own renal excretion by eliciting concentration-dependent secretion of parathyroid hormone (PTH). However, the phosphate-sensing mechanism remains unknown and requires elucidation for understanding the aetiology of ...
Patricia P. Centeno, A. Herberger, Hee‐chang Mun, C. Tu, E. Nemeth, Wenhan Chang, A. Conigrave, D. Ward   +7 more
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Tumor microenvironment induces innate RAF-inhibitor resistance through HGF secretion

Nature, 2012
Drug resistance presents a challenge to the treatment of cancer patients. Many studies have focused on cell-autonomous mechanisms of drug resistance. By contrast, we proposed that the tumour micro-environment confers innate resistance to therapy. Here we
R. Straussman, Teppei Morikawa, K. Shee, Michal Barzily-Rokni, Z. Qian, Jinyan Du, Ashli Davis, Margaret M. Mongare, Joshua Gould, Dennie T. Frederick, Z. Cooper, P. Chapman, D. Solit, A. Ribas, R. Lo, K. Flaherty, S. Ogino, J. Wargo, T. Golub   +18 more
semanticscholar   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Response of the tegument of Fasciola hepatica to infection and immunization sera in vitro

Parasitology
The migratory phase is a critical time for Fasciola hepatica as it must locate, penetrate and migrate through the alimentary tract to the liver parenchyma whilst under attack from the host immune response.
Clive E. Bennett, Adam P.S. Bennett, Robert E.B. Hanna, Mark W. Robinson   +3 more
doaj   +1 more source

The structure of some floral elements and the nectar production rate of Polemonium caeruleum L.

Acta Agrobotanica, 2012
The present study, carried out in the period 2008 - 2009, covered some morphological and anatomical features of the flowers of Polemonium caeruleum L. and their nectar production rate in the climatic conditions of the Lublin region.
Mirosława Chwil
doaj   +1 more source

Insulin Secretion Depends on Intra-islet Glucagon Signaling.

Cell Reports, 2018
The intra-islet theory states that glucagon secretion is suppressed when insulin secretion is stimulated, but glucagon's role in intra-islet paracrine regulation is controversial. This study investigated intra-islet functions of glucagon in mice.
B. Svendsen, Olav Larsen, M. Gabe, C. Christiansen, M. Rosenkilde, D. Drucker, J. Holst   +6 more
semanticscholar   +1 more source