The Secretome From Mechanically Loaded Myoblasts Enhances Tenocyte-Mediated Wound Healing in a 3D In Vitro Tendon Model. [PDF]
FASEB JHuman primary myoblasts were subjected to 2% or 10% static mechanical loading for 24 h, with unloaded cells as controls. Conditioned media were collected and applied, together with normal medium, to a 3D tendon fibrin gel model. Secretome from loaded myoblasts, particularly 2% loading, enhanced tenocyte proliferation, scleraxis (SCX) expression, and ...
Li J +4 more
europepmc +2 more sources
Oncogenic senescence: a multi-functional perspective. [PDF]
, 2017 Cellular senescence is defined as an irreversible growth arrest with the acquisition of a distinctive secretome. The growth arrest is a potent anticancer mechanism whereas the secretome facilitates wound healing, tissue repair, and development.
Alimirah, Fatouma +4 more
core
Stem cells conditioned medium: a new approach to skin wound healing management [PDF]
, 2014 Stem cell biology has gained remarkable interest in recent years, driven by the hope of finding cures for numerous diseases including skin wound healing through transplantation medicine.
Govindasamy, V. +4 more
core +1 more source
3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction
Advanced Science, EarlyView.A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley +1 more source
Immune complexes in chronic Chagas disease patients are formed by exovesicles from Trypanosoma cruzi carrying the conserved MASP N-terminal region [PDF]
, 2017 The exovesicles (EVs) are involved in pathologic host-parasite immune associations and have been recently used as biomarkers for diagnosis of infectious diseases.
De Pablos, Luis Miguel +5 more
core +3 more sources
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, EarlyView.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source
Stem Cell Research & TherapyBackground The secretome of primary bovine mammosphere-derived epithelial cells (MDECs) has been shown to exert antimicrobial, regenerative, and immunomodulatory properties in vitro, which warrants its study as a potential biologic treatment with the ...
Nikola Danev +7 more
doaj +1 more source
Controlling secretion to limit chemoresistance [PDF]
, 2016 The tumor microenvironment influences cancer progression and therapy outcome by mechanisms not yet fully understood. In this issue, Bent et al. (2016) show how chemotherapy causes endothelial senescence.
Georgilis, A, Gil, J
core +1 more source
Advanced Science, EarlyView.Sensory nerves help bones heal. This study shows that the neuropeptide CGRP, released from sensory nerves, slows down macrophage energy production, preventing excessive bone breakdown. By revealing this nerve–immune–metabolism connection, the work provides new insight into how the body balances bone repair and opens doors to targeted treatments ...
Jiaying Liu +10 more
wiley +1 more source
Stage-specific proteomes from onchocerca ochengi, sister species of the human river blindness parasite, uncover adaptations to a nodular lifestyle [PDF]
, 2016 Despite 40 years of control efforts, onchocerciasis (river blindness) remains one of the most important neglected tropical diseases, with 17 million people affected.
Adam +155 more
core +6 more sources