Results 111 to 120 of about 61,645 (272)

Adipocyte‐Derived Exosomal miR‐5099 Mitigates M1 Macrophage Polarization and Adipose Inflammation via c‐Met/NF‐κB Axis to Improve Metabolic Health

Advanced Science, EarlyView.
Celastrol upregulates adipocyte‐derived exosomal miR‐5099, suppressing the macrophage c‐Met/NF‐κB axis to mitigate pro‐inflammatory M1 polarization and adipose inflammation. These miR‐5099‐enriched exosomes also act as endocrine signals targeting the liver, muscle, and adipocytes to significantly enhance systemic insulin sensitivity.
Ping Tang, Lixin Tai, Hongxia Xu, Dongliang Zhu, Jiajia Li, Hao Feng, Jinghui Cui, Shuhai Lin, Li‐jun Di, Li Wang   +9 more
wiley   +1 more source

Proximity‐Induced Transfer of a Mass Tag Enables Direct Profiling of Active Matrix Metalloproteases

Angewandte Chemie, EarlyView.
A proximity‐induced, mass‐encoded activity‐based protein profiling (ABPP) approach transfers a MALDI‐detectable α‐cyano‐4‐hydroxycinnamic acid (CHCA) tag directly to active proteases. This tag enables the direct, multiplexed, and quantitative detection of enzyme activity in complex proteomes without enrichment or purification.
Lomane Berthy, Ugo Pasco, Mylene Sejalon‐Cipolla, Pierrick Bruyat, Monika Kaminska, Carole Malgorn, Fabrice Beau, Manca Osolin, Metka Novak, Barbara Breznik, Dimitris Georgiadis, Isabelle Correia, Emeline Groult, Olivier Lequin, Sarah Bregant, Yves‐Marie Pers, Daniele Noel, Robert Thai, Gilles Subra, Sonia Cantel, Laurent Devel   +20 more
wiley   +2 more sources

PENGARUH SECRETOME SEL PUNCA MESENKIMAL TERHADAP EKSPRESI INTERLEUKIN 17 DAN TUMOR NECROSIS FACTOR ALPHA [PDF]

, 2016
Latar Belakang Systemic Lupus Erythematosus (SLE) adalah penyakit inflamasi autoimun kronis yang belum jelas penyebabnya dengan gambaran klinis yang luas serta tampilan perjalanan penyakit beragam.
Wulandari , Evi Liliek
core   +1 more source

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

Mononuclear cell secretome protects from experimental autoimmune myocarditis [PDF]

, 2017
Aims Supernatants of serum-free cultured mononuclear cells (MNC) contain a mix of immunomodulating factors (secretome), which have been shown to attenuate detrimental inflammatory responses following myocardial ischaemia.
Ankersmit, Hendrik Jan, Birner, Peter, Blyszczuk, Przemyslaw, Eriksson, Urs, Gabriel, Christian, Gyöngyösi, Mariann, Hacker, Stefan, Hegedus, Balazs, Hoetzenecker, Konrad, Hoetzenecker, Wolfram, Kollmann, Dagmar, Mildner, Michael, Mitterbauer, Andreas, Schweiger, Thomas, Zimmermann, Matthias   +14 more
core  

Radiation-induced lung damage promotes breast cancer lung-metastasis through CXCR4 signaling [PDF]

, 2015
Radiotherapy is a mainstay in the postoperative treatment of breast cancer as it reduces the risks of local recurrence and mortality after both conservative surgery and mastectomy.
Bracke, Marc, De Wagter, Carlos, De Wever, Olivier, Descamps, Benedicte, Feys, Lynn, Vanhove, Christian, Veldeman, Liv, Vermeulen, Stefan, Vral, Anne   +8 more
core   +3 more sources

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

Bioinformatic Comparison of Bacterial Secretomes

Genomics, Proteomics & Bioinformatics, 2009
Abstract The rapid increasing number of completed bacterial genomes provides a good opportunity to compare their proteomes. This study was undertaken to specifically compare and contrast their secretomes—the fraction of the proteome with predicted N-terminal signal sequences, both type I and type II.
Song, Catharine, Kumar, Aseem, Saleh, Mazen   +2 more
openaire   +2 more sources

Nanoparticle‐Mediated Immunometabolic‐Epigenetic Remodeling Enhances Schwann Cell‐Macrophage Interaction for Sciatic Nerve Regeneration

Advanced Science, EarlyView.
A biomimetic Prussian White nanoparticle (PW) is engineered to achieve long‐term local retention and orchestrate immunometabolic‐epigenetic remodeling for sciatic nerve regeneration. PW directly targets hexokinase 2 to suppress glycolysis, thereby elevating α‐ketoglutarate and driving Kdm4a/b‐mediated demethylation of H3K9me3.
Wenying Xu, Rongrong Wu, Zhicheng Liu, Hongyu Yan, Huan Zhang, Yuanyi Zheng, Xiaojun Cai   +6 more
wiley   +1 more source

Characteristic Differences between Freeze-dried Tenogenic Secretomes and Freeze-dried Crude Secretomes of Mesenchymal Stem Cells under Hypoxic Conditions

Biomolecular and Health Science Journal
Introduction: Tendons that are crucial for movement are struggling with self-healing. Regenerative medicine has been using mesenchymal stem cells (MSCs) and their secretomes, and it offers promise.
Agus Kresnadi, Mouli Edward, Gilson Khang, Heri Suroto   +3 more
doaj   +1 more source