Results 121 to 130 of about 61,645 (272)

Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties [PDF]

, 2019
Heterogeneous populations of human bone marrow-derived stromal cells (BMSC) are among the most frequently tested cellular therapeutics for treating degenerative and immune disorders, which occur predominantly in the aging population.
Andrzejewska, Anastazja, Beez, Christien, Blankenstein, Antje, Catar, Rusan, Duda, Georg, Geissler, Sven, Jacobi, Dorit, Jürchott, Karsten, Kamhieh-Milz, Julian, Krüger, David, Krüger, Ulrike, Moll, Guido, Qazi, Taimoor Hasan, Reinke, Petra, Reinke, Simon, Richter, Sarina, Sass, Frauke Andrea, Schlickeiser, Stephan, Schoon, Janosch, Souidi, Naima, Streitz, Mathias, Strunk, Dirk, Zemojtel, Tomasz   +22 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Integrative analysis of extracellular and intracellular bladder cancer cell line proteome with transcriptome: improving coverage and validity of -omics findings [PDF]

Characterization of disease-associated proteins improves our understanding of disease pathophysiology. Obtaining a comprehensive coverage of the proteome is challenging, mainly due to limited statistical power and an inability to verify hundreds of ...
Borràs, Daniel M., Frantzi, Maria, Jankowski, Vera, Janssen, Bart, Latosinska, Agnieszka, Makridakis, Manousos, Merseburger, Axel S., Mischak, Harald, Mullen, William, Vlahou, Antonia, Zoidakis, Jerome   +10 more
core   +1 more source

A secretome profile indicative of oleate-induced proliferation of HepG2 hepatocellular carcinoma cells [PDF]

, 2018
Increased fatty acid (FA) is often observed in highly proliferative tumors. FAs have been shown to modulate the secretion of proteins from tumor cells, contributing to tumor survival.
A Michalski, A Raynor, A Slany, A Soto-Guzman, B Shin, B Sun, BM Bolstad, C Arous, C Planque, C Rojas, CA Dumitru, CC Wu, CG Gunawardana, CH Byon, CJ Green, CZ Han, D Hwang, D Wang, Daehee Hwang, DH Jo, F Martinon, G Sardana, H Jiang, H Kawanishi, H Li, H Takata, Hee-Jung Jung, HJ Lee, J Gray, J Hirosumi, J Villen, JA Diepen van, JA Vizcaino, JH Lim, Ji-Hwan Park, Jin-Hyeok Jang, JJ Kamphorst, JL Dixon, Jong Hyuk Yoon, JV Olsen, KJ Travers, KL Meyer-Siegler, KO Yee, L Jin, LC Lim, LN Mueller, M Gronborg, M Hussmann, M Merk, M Tachibana, M Uhlen, M Vinciguerra, M Vinciguerra, MK McElroy, N Jaitly, N Marchi, N Nagaraj, N Santana-Codina, P Grimbert, P Mason, Pann-Ghill Suh, R Ralhan, R Yamashita, RT Poon, S Beloribi-Djefaflia, S Hardy, S Hardy, S Hardy, S Joshi-Barve, S Kim, S Zhao, Sanghyun Ahn, SC Kim, Sehyun Chae, SH Chan, SJ Healy, SJ Kim, Soyeon Park, Sung Ho Ryu, SW Hyung, T Coll, T Farrah, TC Brelje, U Ozcan, V Firlej, VS Tagliabracci, W Cui, W Huang da, X Li, X Yang, XD Lin, Y Kudo, Y Ma, Y Ohtani, Y Ren, Y Wei, YC Tsai, Younah Kim, YT Chen, Z Liu   +99 more
core   +4 more sources

Nanozymes for Liver Disease Therapy: Advances in Catalytic Activity, Targeting Strategies, and Clinical Translation

Advanced Science, EarlyView.
Nanozymes, as enzyme‐mimicking nanomaterials, exhibit unique catalytic properties for the treatment of liver diseases. By regulating redox homeostasis, modulating immune responses, and enabling targeted delivery, nanozymes overcome the limitations of natural enzymes.
Xiandi Meng, Ge Zhu, Siyu Sun, Wenbo Yao, Yuning Zhang, Yong‐Guang Yang, Tianmeng Sun   +6 more
wiley   +1 more source

Angiogenic and Neurotrophic Effects of Human Bone Marrow Mesenchymal Stem Cell-Derived Conditioned Medium for Erectile Dysfunction [PDF]

, 2020
Department of Biomedical EngineeringA three-dimensional spheroid culture system to harvest conditioned medium (CM) from human bone marrow-derived mesenchymal stem cells (hBM-MSCs) with high efficiency were introduced and investigated the therapeutic ...
Kim, Seul Gi
core  

The initiator methionine tRNA drives cell migration and invasion leading to increased metastatic potential in melanoma [PDF]

, 2016
The cell's repertoire of transfer RNAs (tRNAs) has been linked to cancer. Recently, levels of the initiator methionine tRNA (tRNAiMet) in stromal fibroblasts have been shown to influence extracellular matrix (ECM) secretion to drive tumour growth and ...
Birch, Joanna, Blyth, Karen, Campbell, Andrew D., Campbell, Kirsteen, Clarke, Cassie, Kalna, Gabriela, Liko, Dritan, Mitchell, Louise, Neilson, Matthew, Norman, Jim C., Sansom, Owen J., Strathdee, Douglas   +11 more
core   +3 more sources

Draft genome sequence of Colletotrichum acutatum sensu lato (Colletotrichum fioriniae) [PDF]

, 2014
In addition to its economic impact, Colletotrichum acutatum sensu lato is an interesting model for molecular investigations due to the diversity of host-determined specialization and reproductive lifestyles within the species complex.
Alahakoon, Cantarel, Damm, Dean, Freeman, Freeman, Guerber, Horton, Lardner, Lowe, Marcelino, O'Connell, Parra, Sreenivasaprasad, Zerbino   +14 more
core   +3 more sources

Directed Evolution Improves the Catalytic Efficiency of APEX2‐Mediated Proximity‐Dependent RNA Labeling

Advanced Science, EarlyView.
ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley   +1 more source

Dexamethasone marginally surpasses MSC-secretome in resolving acute liver failure in mice

Біологія тварин
The anti-inflammatory roles of Mesenchymal stem cells (MSCs) and glucocorticoids are well-reported in both preclinical and clinical studies. However, it is not clear how far MSC-secretome offers sufficient protection against acute liver failure (ALF ...
Thoria Diab, Eiman M. Adly, Mohamed Hessien   +2 more
doaj   +1 more source