Results 11 to 20 of about 321,020 (307)

Secretory pathway of trypanosomatid parasites [PDF]

Microbiology and Molecular Biology Reviews, 2002
The Trypanosomatidae comprise a large group of parasitic protozoa, some of which cause important diseases in humans. These include Tryanosoma brucei (the causative agent of African sleeping sickness and nagana in cattle), Trypanosoma cruzi (the causative
McConville, Malcolm J., Mullin, Kylie A., Ilgoutz, Steven C., Teasdale, Rohan D.   +3 more
core   +5 more sources

Beyond the Secretory Pathway: New Insights Into Protein Release. [PDF]

Traffic
In eukaryotes, protein secretion plays essential roles in intercellular communications and extracellular niche-building. Protein secretion generally requires a signal sequence that targets cargos to the canonical secretory pathway consisting of the endoplasmic reticulum (ER), the Golgi apparatus, plasma membrane, and vesicles moving between these ...
Chen RH, Costa-Filho AJ, Debnath J, Galli T, Ge L, Goberdhan D, Guo W, He K, Jacob R, Kang T, Lee MG, Li L, Lolicato F, Lu J, Malhotra V, Nickel W, Nikoletopoulou V, Ogden SK, Sagia GM, Shao F, Shi A, Thery C, Vérollet C, Villeneuve J, Verweij F, Wang Y, Wang J, Wu S, Ye Y, Yin H, Yu L, Zhang M, Zhang Y, Zhou X, Zurzolo C.   +34 more
europepmc   +2 more sources

The secretory pathway kinases [PDF]

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2015
Protein phosphorylation is a nearly universal post-translation modification involved in a plethora of cellular events. Even though phosphorylation of extracellular proteins had been observed, the identity of the kinases that phosphorylate secreted proteins remained a mystery until only recently.
Anju, Sreelatha, Lisa N, Kinch, Vincent S, Tagliabracci   +2 more
openaire   +2 more sources

Genome-scale reconstructions of the mammalian secretory pathway predict metabolic costs and limitations of protein secretion

Nature Communications, 2020
The secretory pathway is used in the production of most biopharmaceuticals, but the associated biosynthetic costs are little understood. Here, the authors integrate the core secretory pathway into genome-scale metabolic models of human, mouse, and CHO ...
Jahir M. Gutierrez, Amir Feizi, Shangzhong Li, Thomas B. Kallehauge, Hooman Hefzi, Lise M. Grav, Daniel Ley, Deniz Baycin Hizal, Michael J. Betenbaugh, Bjorn Voldborg, Helene Faustrup Kildegaard, Gyun Min Lee, Bernhard O. Palsson, Jens Nielsen, Nathan E. Lewis   +14 more
doaj   +1 more source

secretory pathway

, 2021
secretion is the movement of material from one point to another .
Ebrahimi, Negar, Tanaz Mohajerani, Khashavi, Samin   +2 more
openaire   +1 more source

Secretory pathways in endothelin synthesis [PDF]

British Journal of Pharmacology, 1999
British Journal of Pharmacology (1999) 126, 391–398; doi:10.1038/sj.bjp ...
F D, Russell, A P, Davenport
openaire   +2 more sources

The key target of neuroprotection after the onset of ischemic stroke: secretory pathway Ca 2+ -ATPase 1

Neural Regeneration Research, 2015
The regulatory mechanisms of cytoplasmic Ca 2+ after myocardial infarction-induced Ca 2+ overload involve secretory pathway Ca 2+ -ATPase 1 and the Golgi apparatus and are well understood.
Li-hua Li, Xiang-rong Tian, Zhi-ping Hu
doaj   +1 more source

Protein trafficking through the endosomal system prepares intracellular parasites for a home invasion [PDF]

, 2013
Toxoplasma (toxoplasmosis) and Plasmodium (malaria) use unique secretory organelles for migration, cell invasion, manipulation of host cell functions, and cell egress. In particular, the apical secretory micronemes and rhoptries of apicomplexan parasites
A Fomovska, AE Topolska, B Lige, B Shen, BF Kafsack, BJ Luft, C Lord, CA Hunter, Chetan E. Chitnis, Christian Slomianny, CY He, D Richard, DL Alexander, F Parussini, H El Hajj, HC Hoppe, HC Hoppe, I Mellman, J Schrevel, JB Dacks, JC Boothroyd, JE Rothman, JF Dubremetz, JM Harper, K Kremer, K Miranda, KA Joiner, KA Joiner, KM Hager, L Pelletier, L Sheiner, LH Bannister, LH Bannister, LM Kats, M Elias, M Tufet-Bayona, M Yang, Markus Meissner, ME Francia, MH Ngo, MH Ngo, MK Shaw, MS Breinich, MS Marks, NA Counihan, PJ Bradley, PJ Sloves, S Mogelsvang, SD Brydges, Stanislas Tomavo, VB Carruthers, Vern B. Carruthers, WM Henne, X Que, Z Dou   +54 more
core   +2 more sources

Ancestral roles of the Fam20C family of secreted protein kinases revealed in C. elegans. [PDF]

, 2019
Fam20C is a secreted protein kinase mutated in Raine syndrome, a human skeletal disorder. In vertebrates, bone and enamel proteins are major Fam20C substrates.
Adina Gerson-Gurwitz, Arribere, Arshad Desai, Bahl, Bando, Bies, Brown, Byerly, Cancino, Carolyn A. Worby, Carrascal, Cui, Dhanya Cheerambathur, Erin J. Cram, Fradin, Frøkjaer-Jensen, Gerald, Ghazarian, Gibson, Gorelik, Green, Ishikawa, Jack E. Dixon, Jeff Bouffard, Johnson, Kamath, Karen Oegema, Kian-Yong Lee, Kim, Kimble, Koike, Koob, Kovacevic, Köppen, Leiser, Leiser, Levin, Lindberg, Mann, Manning, Minko, Mody, Nakamura, Paschinger, Petrella, Pollak, Pollard, Pulvirenti, Raine, Reinhart, Renat Khaliullin, Rolls, Salvi, Sievers, Simpson, Sreelatha, Tagliabracci, Tagliabracci, Tagliabracci, Takeuchi, Tseng, Vogel, Wang, Ward, Wen, Wewer, Xiao, Yue, Zhang, Zhou, Zhou   +70 more
core   +3 more sources

Human protein secretory pathway genes are expressed in a tissue-specific pattern to match processing demands of the secretome [PDF]

, 2017
Protein secretory pathway in eukaryal cells is responsible for delivering functional secretory proteins. The dysfunction of this pathway causes a range of important human diseases from congenital disorders to cancer. Despite the piled-up knowledge on the
Feizi, Amir, Gatto, Francesco, Nielsen, Jens, Uhlén, Mathias   +3 more
core   +2 more sources