Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]
, 2013 Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Crawford, Sue E. +4 more
core +2 more sources
N-glycosylation Triggers a Dual Selection Pressure in Eukaryotic Secretory Proteins
Scientific Reports, 2017 Nearly one third of the eukaryotic proteome traverses the secretory pathway and most of these proteins are N-glycosylated in the lumen of the endoplasmic reticulum.
Máximo Lopez Medus +9 more
doaj +1 more source
A single polar residue and distinct membrane topologies impact the function of the infectious bronchitis coronavirus E protein. [PDF]
PLoS Pathogens, 2012 The coronavirus E protein is a small membrane protein with a single predicted hydrophobic domain (HD), and has a poorly defined role in infection. The E protein is thought to promote virion assembly, which occurs in the Golgi region of infected cells. It
Travis R Ruch, Carolyn E Machamer
doaj +1 more source
Controlling secretion to limit chemoresistance [PDF]
, 2016 The tumor microenvironment influences cancer progression and therapy outcome by mechanisms not yet fully understood. In this issue, Bent et al. (2016) show how chemotherapy causes endothelial senescence.
Georgilis, A, Gil, J
core +1 more source
Incomplete posttranslational prohormone modifications in hyperactive neuroendocrine cells
BMC Cell Biology, 2009 Background In black-background-adapted Xenopus laevis, the intermediate pituitary melanotrope cells are hyperactive, producing large amounts of their major secretory cargo proopiomelanocortin (POMC, representing ~80% of all newly synthesised proteins ...
Martens Gerard JM, Strating Jeroen RPM
doaj +1 more source
Regulation of polarised growth in fungi [PDF]
, 2008 Polarised growth in fungi occurs through the delivery of secretory vesicles along tracks formed by cytoskeletal elements to specific sites on the cell surface where they dock with a multiprotein structure called the exocyst before fusing with the ...
Adamo +112 more
core +1 more source
Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. [PDF]
, 2017 The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions.
Cadwell, Ken, Debnath, Jayanta
core +1 more source
A proteomic atlas of senescence-associated secretomes for aging biomarker development. [PDF]
, 2020 The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer.
Basisty, Nathan +11 more
core +1 more source
The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p. [PDF]
, 2016 Sec2p is a guanine nucleotide exchange factor that activates Sec4p, the final Rab GTPase of the yeast secretory pathway. Sec2p is recruited to secretory vesicles by the upstream Rab Ypt32p acting in concert with phosphatidylinositol-4-phosphate (PI(4)P).
Novick, Peter J, Stalder, Danièle
core +2 more sources
LRP1 modulates APP trafficking along early compartments of the secretory pathway
Neurobiology of Disease, 2008 The amyloid beta peptide (Aβ) is a central player in Alzheimer's disease (AD) pathology. Aβ liberation depends on APP cleavage by β- and γ-secretases. The low density lipoprotein receptor related protein 1 (LRP1) was shown to mediate APP processing at ...
Elaine Waldron +8 more
doaj +1 more source