Results 21 to 30 of about 21,101 (237)

Host-Driven Genetic Diversity of <i>Leptospira</i> in the Americas: A Continental Perspective. [PDF]

Transbound Emerg Dis
Leptospira is a genetically diverse genus of spirochetes comprising over 68 species, including several pathogenic taxa such as L. interrogans, L. santarosai, L. noguchii, and L. weilii. These bacteria infect a wide range of vertebrates, especially mammals, with infected animals serving as renal carriers that excrete the pathogen through urine.
Suárez-Galaz A, Sánchez-Montes S, Torres-Castro M, Chan-Chan R, Yeh-Gorocica A, Moguel-Chin W, Miranda-Caballero CI, Grostieta E, Panti-May A, Ruiz-Piña H, Rodríguez-Vivas RI, Cruz-Romero A, Ojeda-Robertos NF, Reyes-Novelo E.   +13 more
europepmc   +2 more sources

SecY–SecY and SecY–SecG contacts revealed by site‐specific crosslinking [PDF]

FEBS Letters, 2002
Protein translocation across the cytoplasmic membrane of Escherichia coli is mediated by the integral membrane complex SecYEG and the peripherally bound ATPase SecA. To probe the environment of the cytoplasmic domains of SecY within the SecYEG complex, we introduced single cysteine residues in each of the six cytoplasmic domains.
van der Sluis, E.O., Nouwen, N., Driessen, A.J.M.   +2 more
openaire   +3 more sources

A unified evolutionary origin for the ubiquitous protein transporters SecY and YidC

bioRxiv, 2020
Background Protein transporters translocate hydrophilic segments of polypeptide across hydrophobic cell membranes. Two protein transporters are ubiquitous and date back to the last universal common ancestor: SecY and YidC.
Aaron J. O. Lewis, R. Hegde
semanticscholar   +2 more sources

Tapered optical fiber DNA biosensor for detecting Leptospira DNA

Asian Pacific Journal of Tropical Medicine, 2023
Objective: To establish a DNA detection platform based on a tapered optical fiber to detect Leptospira DNA by targeting the leptospiral secY gene. Methods: The biosensor works on the principle of light propagating in the special geometry of the optical ...
Jia-Yong Lam, Mohd Hanif Yaacob, Hui-Yee Chee   +2 more
doaj   +1 more source

Membrane Insertion of the M13 Minor Coat Protein G3p Is Dependent on YidC and the SecAYEG Translocase

Viruses, 2021
The minor coat protein G3p of bacteriophage M13 is the key component for the host interaction of this virus and binds to Escherichia coli at the tip of the F pili.
Farina Kleinbeck, Andreas Kuhn
doaj   +1 more source

Leptospira in Brazilian Bats (Mammalia: Chiroptera): A Systematic Review. [PDF]

Vet Med Sci
We performed a systematic review on bats and Leptospira in Brazil. 8 studies were conducted between 1976 and 2024, with 66 bat taxa found positive, 1 Leptospira species and four serovars identified. Graphical abstract made with Biorender. ABSTRACT Bats are a megadiverse clade with plural ecological functions, including their role as bacterial, viral ...
Braga CDS, Zeppelini CG.
europepmc   +2 more sources

Protease protection assays show polypeptide movement into the SecY channel by power strokes of the SecA ATPase

EMBO Reports, 2020
Bacterial secretory proteins are translocated post‐translationally by the SecA ATPase through the protein‐conducting SecY channel in the plasma membrane. During the ATP hydrolysis cycle, SecA undergoes large conformational changes of its two‐helix finger
Marco A Catipovic, T. Rapoport
semanticscholar   +1 more source

Mobility of the SecA 2-helix-finger is not essential for polypeptide translocation via the SecYEG complex [PDF]

, 2012
The bacterial ATPase SecA and protein channel complex SecYEG form the core of an essential protein translocation machinery. The nature of the conformational changes induced by each stage of the hydrolytic cycle of ATP and how they are coupled to protein ...
Alice Robson, Bauer, Berger, Bessonneau, Breyton, Brundage, Cannon, Dalal, Deville, Ding, Duong, Egea, Erlandson, Erlandson, Gelis, Gold, Gold, Gold, Hizlan, Hunt, Ian Collinson, Karamanou, Lill, Or, Osborne, Osborne, Park, Park, Piggot, Piggot, Richard B. Sessions, Robson, Robson, Robson, Sarah Whitehouse, Tam, Van den Berg, Vicki A.M. Gold, William J. Allen, Wolf, Woodbury, Zimmer, Zimmer   +42 more
core   +2 more sources

Conformational Dynamics of the Plug Domain of the SecYEG Protein-conducting Channel [PDF]

, 2011
The central pore of the SecYEG preprotein-conducting channel is closed at the periplasmic face of the membrane by a plug domain. To study its conformational dynamics, the plug was labeled site-specifically with an environment-sensitive fluorophore.
Arkowitz, Baneyx, Becker, Bol, Bonardi, Bondar, Cabelli, De Keyzer, Driessen, du Plessis, Duong, Egea, Evans, Fekkes, Frauenfeld, Greenough, Gumbart, Hanahan, Harris, Joly, Junne, Klose, Kusters, Lakowicz, Li, Lin, Lycklama, Maillard, Manting, Ménétret, Nakatogawa, Osborne, Plath, Prinz, Ramachandran, Rutkowska, Schaffitzel, Smith, Tam, Tsukazaki, Van den Berg, van der Does, van der Sluis, Zhang, Zimmer   +44 more
core   +2 more sources

Bioinformatics describes novel Loci for high resolution discrimination of leptospira isolates. [PDF]

PLoS ONE, 2010
Leptospirosis is one of the most widespread zoonoses in the world and with over 260 pathogenic serovars there is an urgent need for a molecular system of classification. The development of multilocus sequence typing (MLST) schemes for Leptospira spp.
Gustavo M Cerqueira, Alan J A McBride, Rudy A Hartskeerl, Niyaz Ahmed, Odir A Dellagostin, Marcus R Eslabão, Ana L T O Nascimento   +6 more
doaj   +1 more source