Natural History of Chronic Kidney Disease in Sickle Cell Disease
ABSTRACT Kidney complications, referred to as nephropathy, develop early in sickle cell disease (SCD). In addition to its known morbidity, abundant data show that chronic kidney disease (CKD) is associated with an increased mortality risk in SCD. Increasing evidence suggests that the natural history of SCD nephropathy is progressive. Initial glomerular
Kenneth I. Ataga
wiley +1 more source
Circulating sphingosine-1-phosphate depletion is associated with endothelial activation and altered brain-endothelial S1P pathway expression in ischemic stroke. [PDF]
Porschen LT +6 more
europepmc +1 more source
Ischemia–Reperfusion Injury: Molecular Mechanisms and Therapeutic Interventions
Multiorgan ischemia–reperfusion injury begins with ischemia‐induced ATP depletion and ionic imbalance, followed by reperfusion‐triggered mitochondrial ROS/RNS bursts, regulated cell death, and DAMP release. Sterile inflammation converges on endothelial–immune–coagulation crosstalk, where NETs drive immunothrombosis, no‐reflow, and remote organ injury ...
Peng An +4 more
wiley +1 more source
Platelet-leucocyte interactions drive MMP-mediated tissue damage in tuberculosis. [PDF]
Kirwan DE +14 more
europepmc +1 more source
Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen +6 more
wiley +1 more source
Updates on Mediterranean diet and health status: active ingredients and pharmacological mechanisms
The Mediterranean diet (MedDiet) is among the most extensively studied dietary patterns and has been consistently associated with reduced risk of all‐cause mortality, cardiovascular disease, metabolic disorders, cognitive decline and several types of cancers.
Lukas Schwingshackl +3 more
wiley +1 more source
Combined TIRF and 3D Super-Resolution Microscopy for Nanoscopic Characterization of Adhesion Molecules on Microvilli. [PDF]
Alghamdi A +7 more
europepmc +1 more source
Kinetic measurements of E-selectin/carbohydrate ligand interactions on the cell surface
The kinetic measurements of E-selectin/carbohydrate ligand interactions were performed on the cell surface. The micropipette method was applied to the study of E-selectin/carbohydrate ligand interactions and extended from adhesion kinetic measurements to
龙勉, Huang KS, Zhao H
core
ABSTRACT Inflammatory responses have been shown to contribute significantly to the rejection of grafts in both allo‐ and xenotransplantation. In particular, they play a pivotal role in promoting endothelial activation, complement deposition, and thrombosis, thereby compromising the graft function.
Mitra Gultom +8 more
wiley +1 more source
Tanshinone IIA suppresses cancer metastasis by modulating tumor cell-platelet-endothelial cell interactions. [PDF]
Xu J +7 more
europepmc +1 more source

