Results 151 to 160 of about 12,701 (240)

Lack of Differences in the Pharmacokinetics of Therapeutic Monoclonal Antibodies Between Japanese and Non‐Japanese Individuals

The Journal of Clinical Pharmacology, Volume 66, Issue 8, August 2026.
Abstract Evaluation of the pharmacokinetics (PK) of new drugs in Japanese individuals is regularly requested by the Japanese regulatory agency prior to participation in global clinical trials or for bridging approaches for regulatory approval. However, the need for PK assessments in the Japanese population may be less compelling for monoclonal ...
Paridhi Gupta, Ashish Sharma, Bernd Meibohm   +2 more
wiley   +1 more source

Dysregulation of Neutrophil-Endothelial Communication in Sepsis: Mechanisms and Therapeutic Perspectives. [PDF]

Cells
Esmalian Afyouni N, Kiani MF, Kilpatrick LE.   +2 more
europepmc   +1 more source

Tumour‐Derived Extracellular Vesicles Containing dsRNA Induce Degradation of Ribosomal Protein mRNA in Platelets

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
ABSTRACT Extracellular vesicles (EVs) mediate intercellular communication within the tumour microenvironment by carrying cargoes from paracrine parent cells. EVs have attracted great research interest for their ability to carry nucleic acids into recipient cells and modulate cellular functions.
Gaoge Sun, Yuhuan Tao, Zihan Liu, Kaixiang Zhang, Shuai Zuo, Shanwen Chen, Shufang Ning, Tianyi Zhang, Pengyuan Wang, Ying Zhang, Zhi John Lu, Hang Hubert Yin   +11 more
wiley   +1 more source

Biophysical adaptations of circulating tumor cells undergoing metastasis. [PDF]

Biophys Rep
Liang L, Song X, Wang S, Lim CT.
europepmc   +1 more source

Shear‐Activated von Willebrand Factor Captures Extracellular Vesicles to Promote Platelet Activation and Metastasis

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
Under shear flow, stretched vWF captures platelets and EVs, and TF‐positive EVs amplify platelet activation and aggregation. Although tumour cells do not bind vWF directly, the resulting microthrombi trap circulating tumour cells and promote metastatic progression.
Yuanyuan Wang, Xiaobo Liu, Pascal Nakielski, Katrin Nekipelov, Amanda Salviano‐Silva, Alper Topuz, Alexander T. Bauer, Julian Kött, Jannis Akrivakis, Santra Brenna, Tomasz Downar, Neus Feliu, Gerd Bendas, Berta Puig, Stefan W. Schneider, Dmitry A. Fedosov, Christian Gorzelanny   +16 more
wiley   +1 more source

The Role of Glycans in Human Immunity-A Sweet Code. [PDF]

Molecules
Tvaroška I.
europepmc   +1 more source

Targeting CD162 for Life‐Threatening Cutaneous Chronic Graft‐Versus‐Host Disease: A Case Report

eJHaem, Volume 7, Issue 4, August 2026.
ABSTRACT Steroid‐refractory chronic cutaneous graft‐versus‐host disease (GVHD) causes substantial morbidity, prolonged hospitalization, and non‐relapse mortality after allogeneic hematopoietic cell transplantation. We report a young adult with multisystem chronic GVHD and recurrent life‐threatening inflammatory skin flares refractory to multiple ...
Alicia Lieberman, Ross McCauley, Maureen Ross, Philip McCarthy, Iming Cho, Simona Reed, Shih‐Yao Lin, Judy Chou, Shernan G. Holtan   +8 more
wiley   +1 more source

Key role of the endothelium in lung ischemia-reperfusion injury: What the clinician needs to know. [PDF]

JHLT Open
Besnier E, Clavier T, Bellien J, Selim J.   +3 more
europepmc   +1 more source

Risk Factors for Cardiovascular Disease: Epidemiology, Screening, Prevention, and Therapeutic Interventions

MedComm, Volume 7, Issue 8, August 2026.
Cardiovascular disease arises from lifelong accumulation of traditional and emerging risk factors that converge on shared pathophysiological pathways, leading to diverse clinical outcomes, and can be mitigated through integrated screening, prevention, and precision therapies. ABSTRACT Cardiovascular diseases (CVDs) remain the leading cause of morbidity
Mowei Kong, Zaiyong Zheng, Min Huang, Shengyu Huang, Xingwei Zhao, Yang Yu, Chunxiang Zhang   +6 more
wiley   +1 more source

Lipid alterations and endothelial dysfunction are associated with multiple sclerosis pathophysiology. [PDF]

Sci Rep
Damiza-Detmer A, Pawełczyk M, Bednarski I, Szpakowski P, Głąbiński A.   +4 more
europepmc   +1 more source