Results 171 to 180 of about 24,758 (269)

T Cell Immunosenescence in Inflammatory Skin Diseases: Pathogenesis and Therapeutic Targets

Aging Cell, Volume 25, Issue 5, May 2026.
Immunosenescent T cells promote inflammatory skin diseases such as psoriasis, atopic dermatitis, rosacea, and seborrheic dermatitis via hyperactive signaling networks and SASP secretion. Consequently, intercepting downstream SASP, inhibiting internal pathways, or utilizing senolytics represents promising therapeutic interventions.
Conghui Liu, Ming Yang, Fugang Xiao, Jinrong Zeng   +3 more
wiley   +1 more source

Vessel‐associated microglia are differentially activated and distributed in relation to systemic infection and Alzheimer's disease

Brain Pathology, Volume 36, Issue 3, May 2026.
This post‐mortem study revealed an increased density of vessel‐associated microglia (VAM) in the temporal lobe in systemic infection and Alzheimer's disease. VAM density was related to brain cytokine levels and markers of cerebrovascular dysfunction and BBB leakage indicating that activated VAM contributes to neurovascular injury in Alzheimer's disease.
Oliver Milner, Robert A. Fisher, Daniel J. Asby, Stephen Cross, Delphine Boche, J. Scott Miners   +5 more
wiley   +1 more source

From Cerebrovascular Injury to Brain Cancer: The Role of Blood-Brain Barrier Dysfunction. [PDF]

Biomedicines
Kisiel S, Pawlik M, Niemcewicz WJ, Janicki W, Świerczyńska J, Romanczuk K, Zdanowski R, Borkowska A.   +7 more
europepmc   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

Mechanoimmunology: past, present, and future perspectives. [PDF]

Mechanobiol Med
Zhu C.
europepmc   +1 more source

From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology

Immunological Reviews, Volume 339, Issue 1, May 2026.
ABSTRACT The thymic medulla is essential for establishing central tolerance, orchestrating the development of a diverse yet self‐tolerant T cell repertoire, and preventing autoimmunity. This process is primarily mediated through interactions between developing thymocytes and antigen‐presenting cells, including thymic epithelial cells (TECs) and ...
Christina Michalaki, Minahil Sharjeel, Jennifer E. Cowan   +2 more
wiley   +1 more source

Cardiovascular biomarkers and preeclampsia: A narrative review. [PDF]

Eur J Clin Invest
Ullmo J, Nan MN, Cruz-Lemini M, Garrido-Gimenez C, Platero J, García-Osuna Á, García-Manau P, Twickler M, Llurba E.   +8 more
europepmc   +1 more source

Microvascular Effects of Endocannabinoid Signaling in Sepsis: A Mechanistic and Systematic Review

Microcirculation, Volume 33, Issue 4, May 2026.
ABSTRACT Microvascular dysfunction is a central determinant of organ failure in sepsis, reflecting early endothelial activation, increased permeability, and impaired capillary perfusion. Experimental evidence suggests that the endocannabinoid system (ECS) modulates these immunovascular processes, yet mechanistic insights remain dispersed across ...
Emanuel F. Matias, Francisco M. Vila‐Real, Maria A. Vieira‐Coelho   +2 more
wiley   +1 more source

Mechanisms That Prevent Vascular Leakage During Leukocyte Extravasation. [PDF]

Acta Physiol (Oxf)
de Haan SJ, van Buul JD.
europepmc   +1 more source

Dysregulation of Neutrophil-Endothelial Communication in Sepsis: Mechanisms and Therapeutic Perspectives. [PDF]

Cells
Esmalian Afyouni N, Kiani MF, Kilpatrick LE.   +2 more
europepmc   +1 more source