Results 251 to 260 of about 14,056 (288)

Ligand-specificity of the selectins

Journal of Cellular Biochemistry, 1996
The selectins are carbohydrate-binding cell adhesion molecules acting in the vascular system. They mediate the docking of leukocytes to the blood vessel wall and the rolling of these cells along the endothelial cell surface. These adhesion phenomena initiate the entry of leukocytes into sites of inflammation as well as the migration of recirculating ...
Dietmar Vestweber
exaly   +3 more sources

The selectin–selectin ligand axis in tumor progression

Cancer and Metastasis Reviews, 2008
This review will document that the selectin-selectin ligand axis is actively involved in tumor progression and drives this process. The involvement of selectins and their ligands in tumor progression takes place at three levels which will be reviewed: Interaction of tumor cells with platelets and leukocytes resulting in the formation of circulating ...
openaire   +2 more sources

Molecular Stiffness of Selectins [PDF]

Journal of Biological Chemistry, 2011
During inflammation, selectin-ligand interactions provide forces for circulating leukocytes to adhere to vascular surfaces, which stretch the interacting molecules, suggesting that mechanical properties may be pertinent to their biological function. From mechanical measurements with atomic force microscopy, we analyzed the molecular characteristics of ...
Rodger P Mcever, Cheng Zhu
exaly   +3 more sources

E‐selectin and L‐selectin polymorphisms in patients with periodontitis

Journal of Periodontal Research, 2009
Background amd Objective:  Periodontitis is a multifactorial disease in which environmental and genetic determinant factors contribute to individual subject’s susceptibility. A DNA polymorphism in the regulating region of adhesion molecule genes is suggested to modulate the molecule’s physiological effects.
B, Houshmand, A, Rafiei, M, Hajilooi, K, Mani-Kashani, L, Gholami   +4 more
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Functions of Selectins

2001
The selectins are cell surface lectins that have evolved to mediate the adhesion of white blood cells to endothelial cells and platelets under flow. They recognize fucosylated, sialylated and in some cases sulfated ligands expressed on scaffold glycoproteins serving as functional counter-receptors.
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Serum L-selectin and P-selectin levels in lymphomas

Haematologia, 2000
The migration of normal and malignant lymphoid cells is governed by specific adhesion molecules. Selectins comprise a family of adhesion receptors expressed by leukocytes, platelets and endothelial cells. In this study, the serum levels of soluble L-selectin and P-selectin were measured in patients with non-Hodgkin's lymphoma and Hodgkin's disease and ...
I C, Haznedaroglu, M, Benekli, O, Ozcebe, M C, Savaş, I H, Güllü, S V, Dündar, S, Kirazli   +6 more
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The Selectins and Their Ligands

1993
Among the four major groups of cell adhesion molecules (CAMs) the selectins represent the smallest and most recently identified gene family (Lasky 1992; Vestweber 1992). In contrast to the three large families of the integrins, the immunoglobulin super gene family and the cadherins, the selectins consist of only three members: L-, E-, and P-selectin ...
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The selectins: Insights into selectin-induced intracellular signaling in leukocytes

Immunologic Research, 1995
Characteristic features of the inflammatory and immune responses involve the recruitment of leukocytes to sites of tissue injury and the recirculation of lymphocytes through hematopoietic and lymphoid tissues. Recent studies indicate that the regulated cell surface expression of a family of protein adhesion molecules known as selectins and their ...
E, Crockett-Torabi, J C, Fantone
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Fibrinogen selects selectins

Blood, 2009
In this issue of Blood , Yang and colleagues provide new insights into how plasma fibrinogen, fibrinogen uptake, and integrin signaling regulate P-selectin in circulating platelets.[1][1] Membrane P-selectin expression is considered one of the most reliable markers of murine and human ...
Hansjörg, Schwertz, Guy A, Zimmerman, Andrew S, Weyrich   +2 more
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Zooming in on selectins in cancer

Science Translational Medicine, 2016
Selectins are involved in leukocyte and cancer cell trafficking, which can be targeted with drugs and nanoparticles (Shamay et al. , this issue).
Ranit, Kedmi, Dan, Peer
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