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Hitchhiking on selective autophagy
Nature Cell Biology, 2018Selective autophagy is important for controlled degradation of cellular components. However, a selective autophagic degradation mechanism for ribosomes in mammals has remained unclear. A study now describes non-selective and selective ribosome degradation and a significant role for ‘bystander’ non-selective autophagy.
Christian, Münch, Ivan, Dikic
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The role of ALFY in selective autophagy [PDF]
Cell Death and Differentiation, 2012 Autophagy, a highly conserved lysosomal degradation pathway, was initially characterized as a bulk degradation system induced in response to starvation. In recent years, autophagy has emerged also as a highly selective pathway, targeting various cargoes such as aggregated proteins and damaged organelles for degradation.
Petter Holland, Anne Simonsen
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Membrane recruitment of autophagy proteins in selective autophagy
Hepatology Research, 2012Autophagy is a stress response that is upregulated in response to signals such as starvation, growth factor deprivation, endoplasmic reticulum stress, and pathogen infection. Defects in this pathway are the underlying cause of a number of diseases, including metabolic aberrations, infectious diseases, and cancer, which are closely related to hepatic ...
Eiji, Morita, Tamotsu, Yoshimori
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Function of Atg11 in non-selective autophagy and selective autophagy of Candida albicans
Biochemical and Biophysical Research Communications, 2019Candida albicans is an important opportunistic pathogenic fungus in the human body. It is a common microbe inhabiting on the mucosa surfaces of healthy individuals, but may cause infections when the host immune system is weak. Autophagy is a "self-eating" process in eukaryotes, which can recover and utilize damaged organelles and misfolded proteins ...
Lifang Cui +7 more
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Huntingtin facilitates selective autophagy
Nature Cell Biology, 2015Selective autophagy is essential for maintaining cellular homeostasis under different growth conditions. Huntingtin, mutated versions of which have been implicated in Huntington disease, is now shown to act as a scaffold protein that couples the induction of autophagy and the selective recruitment of cargo into autophagosomes.
Amir, Gelman +2 more
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Selective degradation of p62 by autophagy
Seminars in Immunopathology, 2010The autophagy-lysosome pathway is a highly conserved bulk degradation system in eukaryotes. During starvation, cytoplasmic constituents are non-selectively degraded by autophagy, and the resulting amino acids are utilized for cell survival. By taking advantage of mouse genetics, many physiological functions of mammalian autophagy have been uncovered ...
Yoshinobu, Ichimura, Masaaki, Komatsu
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Multifaceted roles of ATM in autophagy: From nonselective autophagy to selective autophagy
Cell Biochemistry and Function, 2019The ataxia‐telangiectasia mutated (ATM) protein kinase is best known for its critical nuclear roles in the DNA damage response (DDR), cell cycle checkpoints, and the maintenance of gene stability. In this review, we highlight the multifaceted cytoplasmic functions of ATM in autophagy.
Nan Liang +3 more
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LC3B is indispensable for selective autophagy of p62 but not basal autophagy
Biochemical and Biophysical Research Communications, 2014Autophagy is a unique intracellular protein degradation system accompanied by autophagosome formation. Besides its important role through bulk degradation in supplying nutrients, this system has an ability to degrade certain proteins, organelles, and invading bacteria selectively to maintain cellular homeostasis.
Yoko, Maruyama +7 more
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Selective Autophagy and Cancer
2013In normal cells, autophagy prevents tumorigenesis through selective cleanup of damaged organelles and certain specific proteins such as p62. In contrast, autophagy provides tumor cells, which require enormous amounts of nutrients, with amino acids, fatty acids, and glucose. Therefore, autophagy represents something of a double-edged sword in cancer: it
Yoshinobu Ichimura, Masaaki Komatsu
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The mechanisms and roles of selective autophagy in mammals
Nature Reviews Molecular Cell Biology, 2022JOSÉ Norberto S Vargas +2 more
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