Results 91 to 100 of about 2,192,641 (235)

Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins [PDF]

, 2019
Autophagy is an essential recycling and quality control pathway. Mammalian ATG8 proteins drive autophagosome formation and selective removal of protein aggregates and organelles by recruiting autophagy receptors and adaptors that contain a LC3 ...
Zhang, W, Mouilleron, S, Wirth, Martina, Razi, Minoo, Mouilleron, Stephane, Wirth, M, Tooze, Sharon, Johansen, T, Nyoni, L, O'Reilly, Nicola, Joshi, D, Zhang, Wenxin, Nyoni, Lynet, Razi, M, O'Reilly, N, Joshi, Dhira, Tooze, SA, Johansen, Terje   +17 more
core   +1 more source

PABPC4 Inhibits SADS-CoV Replication by Degrading the Nucleocapsid Protein Through Selective Autophagy

Veterinary Sciences
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a novel enteric coronavirus that causes severe clinical diarrhea and intestinal pathological injury in pigs.
Chenchen Zhao, Yan Qin, Haixin Huang, Wei Chen, Yanqing Hu, Xinyu Zhang, Yuying Li, Tian Lan, Wenchao Sun   +8 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Cutting a fine figure : On the use of thin sections in electron microscopy to quantify autophagy [PDF]

, 2013
Over the last few years, two guideline articles have been published with recommendations for assessing autophagy. These articles contained advice on quantification of autophagy by electron microscopy and proposed using thin slices for quantifying ...
Hacker, Christian, Lucocq, John Milton
core   +1 more source

Host autophagy machinery is diverted to the pathogen interface to mediate focal defense responses against the Irish potato famine pathogen

eLife, 2018
During plant cell invasion, the oomycete Phytophthora infestans remains enveloped by host-derived membranes whose functional properties are poorly understood. P.
Yasin F Dagdas, Pooja Pandey, Yasin Tumtas, Nattapong Sanguankiattichai, Khaoula Belhaj, Cian Duggan, Alexandre Y Leary, Maria E Segretin, Mauricio P Contreras, Zachary Savage, Virendrasinh S Khandare, Sophien Kamoun, Tolga O Bozkurt   +12 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

NBR1a mediates root-knot nematode resistance by modulating antioxidant system, jasmonic acid and selective autophagy in Solanum lycopersicum

Plant Stress
Root-knot nematodes (RKNs; Meloidogyne incognita) are recognized as the most destructive plant pathogenic nematodes, posing a significant threat to global food security.
Ting Yang, Weiduo Jin, Jinping Zou, Xinlin Chen, Qiufeng Zhao, Jingquan Yu, Jie Zhou   +6 more
doaj   +1 more source

A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress

eLife, 2020
Eukaryotes have evolved various quality control mechanisms to promote proteostasis in the endoplasmic reticulum (ER). Selective removal of certain ER domains via autophagy (termed as ER-phagy) has emerged as a major quality control mechanism.
Madlen Stephani, Lorenzo Picchianti, Alexander Gajic, Rebecca Beveridge, Emilio Skarwan, Victor Sanchez de Medina Hernandez, Azadeh Mohseni, Marion Clavel, Yonglun Zeng, Christin Naumann, Mateusz Matuszkiewicz, Eleonora Turco, Christian Loefke, Baiying Li, Gerhard Dürnberger, Michael Schutzbier, Hsiao Tieh Chen, Alibek Abdrakhmanov, Adriana Savova, Khong-Sam Chia, Armin Djamei, Irene Schaffner, Steffen Abel, Liwen Jiang, Karl Mechtler, Fumiyo Ikeda, Sascha Martens, Tim Clausen, Yasin Dagdas   +28 more
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Elastase induces lung epithelial cell autophagy through placental growth factor A new insight of emphysema pathogenesis

, 2017
Chronic obstructive pulmonary disease (COPD) is a devastating disease, which is associated with increasing mortality and morbidity. Therefore, there is a need to clearly define the COPD pathogenic mechanism and to explore effective therapies.
Hou, Hsin-Han;Cheng, Shih-Lung;Chung, Kuei-Pin;Kuo, Mark Yen-Ping;Yeh, Cheng-Chang;Chang, Bei-En;Lu, Hsuan-Hsuan;Wang, Hao-Chien;Yu, Chong-Jen, 王鶴健;張百恩;余忠仁;郭彥彬;鐘桂彬   +1 more
core   +1 more source