Results 81 to 90 of about 2,192,641 (235)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling [PDF]

, 2009
BackgroundMammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular functions including autophagy, a process of cellular self-eating activated by nutrient depletion ...
Trevor C F Tsang, Roberge, Michel, Bruno D Fonseca, Patrick Lajoie, Tsang, Trevor C. F., Lajoie, Patrick, Proud, Christopher G., Aruna D Balgi, Michel Roberge, Tsang Trevor C. F., Ivan R Nabi, Lajoie, P., Nabi Ivan R., Fonseca, B., Balgi, Aruna D., Fonseca, Bruno D., Proud, C., Tsang, T., Balgi, A., Nabi, Ivan R., Roberge, M., Balgi Aruna D., Proud Christopher G., Lajoie Patrick, Roberge Michel, Donohue, Elizabeth, Christopher G Proud, Donohue Elizabeth, Nabi, I., Fonseca Bruno D., Donohue, E., Elizabeth Donohue   +31 more
core   +2 more sources

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Decoding the molecular mechanism of selective autophagy of glycogen mediated by autophagy receptor STBD1

Proceedings of the National Academy of Sciences
Autophagy of glycogen (glycophagy) is crucial for the maintenance of cellular glucose homeostasis and physiology in mammals. STBD1 can serve as an autophagy receptor to mediate glycophagy by specifically recognizing glycogen and relevant key autophagic factors, but with poorly understood mechanisms. Here, we systematically characterize the interactions
Yuchao Zhang, Yishan Sun, Jungang Shi, Peng Xu, Yingli Wang, Jianping Liu, Xinyu Gong, Yaru Wang, Yubin Tang, Haobo Liu, Xindi Zhou, Zhiqiao Lin, Otto Baba, Tsuyoshi Morita, Biao Yu, Lifeng Pan   +15 more
openaire   +4 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Hrr25 triggers selective autophagy–related pathways by phosphorylating receptor proteins [PDF]

Journal of Cell Biology, 2014
In selective autophagy, degradation targets are specifically recognized, sequestered by the autophagosome, and transported into the lysosome or vacuole. Previous studies delineated the molecular basis by which the autophagy machinery recognizes those targets, but the regulation of this process is still poorly understood. In this paper, we find that the
Chikara Tanaka, Li-Jing Tan, Keisuke Mochida, Hiromi Kirisako, Michiko Koizumi, Eri Asai, Machiko Sakoh-Nakatogawa, Yoshinori Ohsumi, Hitoshi Nakatogawa   +8 more
openaire   +2 more sources

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Autophagy and selective autophagy receptors: Key players against Alzheimer’s disease

Neural Regeneration Research
The devastating neurodegenerative disorder of Alzheimer’s disease hallmarks the presence of protein aggregates known as amyloid-β plaques and neurofibrillary tangles, composed of amyloid-β peptides and aberrantly phosphorylated Tau protein, respectively.
Krenare Bruqi, Flavie Strappazzon
openaire   +2 more sources

Autophagy receptor optineurin promotes autophagosome formation by potentiating LC3-II production and phagophore maturation

Communicative & Integrative Biology, 2018
Autophagy is an essential physiological process that maintains cellular homeostasis by eliminating harmful protein aggregates, damaged organelles and certain pathogens through lysosomal degradation.
Megha Bansal, Shivranjani C Moharir, Ghanshyam Swarup   +2 more
doaj   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source