Mechanisms of selective autophagy and mitophagy: Implications for neurodegenerative diseases
Neurobiology of Disease, 2019 Over the past 20 years, the concept of mammalian autophagy as a nonselective degradation system has been repudiated, due in part to important discoveries in neurodegenerative diseases, which opened the field of selective autophagy. Protein aggregates and
Charleen T. Chu
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New insights into AtNBR1 as a selective autophagy cargo receptor in Arabidopsis [PDF]
Plant Signaling & Behavior, 2020 Selective autophagy, mediated by cargo receptors and recruiting specific targets to autophagosomes for degradation and recycling, plays an important role in quality control and cellular homeostasis in eukaryotes. The Arabidopsis AtNBR1 shares a similar domain organization with the mammalian autophagic receptors p62 and NBR1.
Youshun, Lin +4 more
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Msn2/4 transcription factors positively regulate expression of Atg39 ER-phagy receptor
Scientific Reports, 2021 Selective autophagy requires the autophagy receptor specifically localizing to the target for degradation. In the budding yeast, Atg39 and Atg40 function as an autophagy receptor for the endoplasmic reticulum (ER)-selective autophagy, referred to as ER ...
Tomoaki Mizuno, Kenji Irie
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ROOT HAIR DEFECTIVE3 Is a Receptor for Selective Autophagy of the Endoplasmic Reticulum in Arabidopsis [PDF]
Frontiers in Plant Science, 2022 ROOT HAIR DEFECTIVE3 (RHD3) is a plant member of atlastin GTPases, which belong to an evolutionally conserved family of proteins that mediate the homotypic fusion of the endoplasmic reticulum (ER). An atlastin in mammalian cells has recently been shown to act as an ER-phagy receptor for selective autophagy of the ER (ER-phagy) during nutrient ...
Jiaqi Sun, Weina Wang, Huanquan Zheng
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Ubiquitin-coated nanodiamonds bind to autophagy receptors for entry into the selective autophagy pathway [PDF]
Autophagy, 2017 Selective macroautophagy/autophagy plays a pivotal role in the processing of foreign pathogens and cellular components to maintain homeostasis in human cells. To date, numerous studies have demonstrated the uptake of nanoparticles by cells, but their intracellular processing through selective autophagy remains unclear.
Kuang-Kai, Liu +11 more
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RETREG3/FAM134C phosphorylation by CSNK2 regulates reticulophagy during starvation
Autophagy Reports, 2022 Starvation is the most potent physiological inducer of autophagy, the catabolic process which degrades unessential cytosolic components to sustain cellular homeostasis and survival.
Giorgia Di Lorenzo +4 more
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MIR376A is a regulator of starvation-induced autophagy [PDF]
, 2013 Background: Autophagy is a vesicular trafficking process responsible for the degradation of long-lived, misfolded or abnormal proteins, as well as damaged or surplus organelles.
Gozuacik Devrim +25 more
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iLIR : a web resource for prediction of Atg8-family interacting proteins [PDF]
, 2014 Macroautophagy was initially considered to be a nonselective process for bulk breakdown of cytosolic material. However, recent evidence points toward a selective mode of autophagy mediated by the so-called selective autophagy receptors (SARs).
Nezis, I. P. +6 more
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Nature Communications, 2019 While the cellular recycling process autophagy has been linked to aging, the impact of selective autophagy on lifespan remains unclear. Here Kumsta et al.
Caroline Kumsta +12 more
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Sterical Hindrance Promotes Selectivity of the Autophagy Cargo Receptor NDP52 for the Danger Receptor Galectin-8 in Antibacterial Autophagy [PDF]
Science Signaling, 2013 A crystal structure of an autophagy receptor with a ligand reveals how Salmonella is specifically targeted for degradation.
Sai, Li +7 more
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