Results 31 to 40 of about 2,192,641 (235)
Spatiotemporal dynamics of autophagy receptors in selective mitophagy [PDF]
Autophagy, 2016 Damaged mitochondria are turned over through a process of selective autophagy termed mitophagy. In mitophagy, unhealthy mitochondria are recognized and ubiquitinated by Parkinson disease-linked proteins PINK1 and PARK2. The subsequent recruitment of ubiquitin-binding autophagy receptors leads in turn to the sequestration of the damaged organelles into ...
Andrew S, Moore, Erika L F, Holzbaur
openaire +2 more sources
Early endosomes and endosomal coatomer are required for autophagy [PDF]
, 2009 Autophagy, an intracellular degradative pathway, maintains cell homeostasis under normal and stress conditions. Nascent double-membrane autophagosomes sequester and enclose cytosolic components and organelles, and subsequently fuse with the endosomal ...
Tooze, Sharon A. +2 more
core +4 more sources
Identification and functional analysis of Joka2, a tobacco member of the family of selective autophagy cargo receptors [PDF]
, 2011 Two main mechanisms of protein turnover exist in eukaryotic cells: the ubiquitin-proteasome system and the autophagylysosomal pathway. Autophagy is an emerging important constituent of many physiological and pathological processes, such as response to ...
Sirko, Agnieszka +17 more
core +1 more source
Inverted recruitment of autophagy proteins to the Plasmodium berghei parasitophorous vacuole membrane. [PDF]
PLoS ONE, 2017 Selective autophagy and related mechanisms can act as variable defense mechanisms against pathogens and can therefore be considered as intracellular immune responses.
Jacqueline Schmuckli-Maurer +5 more
doaj +1 more source
eLife, 2022 Autophagy receptor (or adaptor) proteins facilitate lysosomal destruction of various organelles in response to cellular stress, including nutrient deprivation. To what extent membrane-resident autophagy receptors also respond to organelle-restricted cues
Houqing Yu +2 more
doaj +1 more source
Macrophage autophagy in atherosclerosis [PDF]
, 2013 Macrophages play crucial roles in atherosclerotic immune responses. Recent investigation into macrophage autophagy (AP) in atherosclerosis has demonstrated a novel pathway through which these cells contribute to vascular inflammation.
Platt, A. +16 more
core +1 more source
A Model of Autophagy Size Selectivity by Receptor Clustering on Peroxisomes [PDF]
Frontiers in Physics, 2017 Selective autophagy must not only select the correct type of organelle, but also must discriminate between individual organelles of the same kind so that some but not all of the organelles are removed. We propose that physical clustering of autophagy receptor proteins on the organelle surface can provide an appropriate all-or-none signal for organelle ...
Aidan I. Brown +2 more
openaire +3 more sources
Multiple Functions of ATG8 Family Proteins in Plant Autophagy
Frontiers in Cell and Developmental Biology, 2020 Autophagy is a major degradation process of cytoplasmic components in eukaryotes, and executes both bulk and selective degradation of targeted cargos.
Fan Bu +6 more
doaj +1 more source
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) [PDF]
, 2022 Funding: This work was supported by the National Institute of General Medical Sciences [GM131919].In 2008, we published the first set of guidelines for standardizing research in autophagy.
Autophagy Group +2 more
core +1 more source
Nature Communications, 2017 Selective autophagy describes the selective degradation of cellular components upon stress or nutrient deficiency, but whether it modulates innate immunity is unclear.
Radu Tusco +6 more
doaj +1 more source