Results 21 to 30 of about 2,192,641 (235)
Cargo Recognition and Function of Selective Autophagy Receptors in Plants [PDF]
International Journal of Molecular Sciences, 2021 Autophagy is a major quality control system for degradation of unwanted or damaged cytoplasmic components to promote cellular homeostasis. Although non-selective bulk degradation of cytoplasm by autophagy plays a role during cellular response to nutrient deprivation, the broad roles of autophagy are primarily mediated by selective clearance of ...
Shuwei Luo +6 more
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A Diversity of Selective Autophagy Receptors Determines the Specificity of the Autophagy Pathway [PDF]
Molecular Cell, 2019 The clearance of surplus, broken, or dangerous components is key for maintaining cellular homeostasis. The failure to remove protein aggregates, damaged organelles, or intracellular pathogens leads to diseases, including neurodegeneration, cancer, and infectious diseases.
Kirkin, Vladimir, Rogov, Vladimir V.
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The role of Tecpr1 in selective autophagy as a cargo receptor [PDF]
Autophagy, 2011 Bacterial intrusion of host cells can be recognized by the innate immune system, including autophagy, via multiple cellular pathways. We have identified Tecpr1 as an Atg5-binding partner, and found that Tecpr1 interacts with the Atg12-Atg5-Atg16L1 complex via binding to Atg5.
Michinaga, Ogawa, Chihiro, Sasakawa
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Nix is a selective autophagy receptor for mitochondrial clearance [PDF]
The EMBO Reports, 2009 Autophagy is the cellular homeostatic pathway that delivers large cytosolic materials for degradation in the lysosome. Recent evidence indicates that autophagy mediates selective removal of protein aggregates, organelles and microbes in cells. Yet, the specificity in targeting a particular substrate to the autophagy pathway remains poorly understood ...
Novak, Ivana +14 more
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Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation [PDF]
Nature Communications, 2021 Abstract The ULK complex initiates the autophagosome formation, and has recently been implicated in selective autophagy by interacting with autophagy receptors through its FIP200 subunit. However, the structural mechanism underlying the interactions of autophagy receptors with FIP200 and the relevant regulatory mechanism remain ...
Zixuan Zhou +12 more
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The receptor proteins: pivotal roles in selective autophagy [PDF]
Acta Biochimica et Biophysica Sinica, 2015 Autophagy is a highly regulated and multistep biological process whereby cells under metabolic, proteotoxic, or other stresses remove dysfunctional organelles and/or misfolded/polyubiquitinated proteins by shuttling them via specialized structures called autophagosomes to the lysosome for degradation.
Zhijie, Xu +4 more
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Oligomerization of Selective Autophagy Receptors for the Targeting and Degradation of Protein Aggregates [PDF]
Cells, 2021 The selective targeting and disposal of solid protein aggregates are essential for cells to maintain protein homoeostasis. Autophagy receptors including p62, NBR1, Cue5/TOLLIP (CUET), and Tax1-binding protein 1 (TAX1BP1) proteins function in selective autophagy by targeting ubiquitinated aggregates through ubiquitin-binding domains.
Wenjun Chen +3 more
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The selectivity and specificity of autophagy in drosophila [PDF]
, 2012 Autophagy is a process of cellular self-degradation and is a major pathway for elimination of cytoplasmic material by the lysosomes. Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a ...
Nezis, I. P., Ioannis P. Nezis
core +1 more source
Autophagy in Drosophila : from historical studies to current knowledge [PDF]
, 2014 The discovery of evolutionarily conserved Atg genes required for autophagy in yeast truly revolutionized this research field, and made it possible to carry out functional studies in model organisms.
Nezis, I. P. +13 more
core +1 more source
Nature Communications, 2023 Selective autophagy is a double-edged sword in antiviral immunity and regulated by various autophagy receptors. However, it remains unclear how to balance the opposite roles by one autophagy receptor.
Xin Tong +8 more
doaj +1 more source