Results 11 to 20 of about 2,192,641 (235)
Receptor Proteins in Selective Autophagy [PDF]
International Journal of Cell Biology, 2012 Autophagy has long been thought to be an essential but unselective bulk degradation pathway. However, increasing evidence suggests selective autophagosomal turnover of a broad range of substrates.
Christian Behrends, Simone Fulda
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Quantitative Phosphoproteomics of Selective Autophagy Receptors
, 2022 S.691-701Selective autophagy enables degradation of specific cargo such as protein aggregates or organelles and thus plays an essential role in the regulation of cellular homeostasis. Cargo specificity is achieved on the level of autophagy receptors that
Dikic, I., Beli, P., Juretschke, T.
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Broad and Complex Roles of NBR1-Mediated Selective Autophagy in Plant Stress Responses
Cells, 2020 Selective autophagy is a highly regulated degradation pathway for the removal of specific damaged or unwanted cellular components and organelles such as protein aggregates.
Yan Zhang, Zhixiang Chen
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Mechanism of autophagy initiation by transmembrane selective autophagy receptors
The EMBO JournalSelective autophagy ensures the targeted degradation of damaged or surplus cellular components, including organelles, thereby safeguarding cellular homeostasis.
Elias Adriaenssens, Sascha Martens
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A guide to the regulation of selective autophagy receptors [PDF]
The FEBS Journal, 2021 Autophagy is a highly conserved catabolic process cells use to maintain their homeostasis by degrading misfolded, damaged and excessive proteins, nonfunctional organelles, foreign pathogens and other cellular components. Hence, autophagy can be nonselective, where bulky portions of the cytoplasm are degraded upon stress, or a highly selective process ...
Andrea Gubas, Ivan Dikic
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Tracking autophagy during proliferation and differentiation of Trypanosoma brucei [PDF]
, 2014 Autophagy is a lysosome-dependent degradation mechanism that sequesters target cargo into autophagosomal vesicles. The Trypanosoma brucei genome contains apparent orthologues of several autophagy-related proteins including an ATG8 family. These ubiquitin-
Mottram, Jeremy +3 more
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Selective Autophagy Receptors in Antiviral Defense
Trends in Microbiology, 2021 Autophagy ensures the degradation of cytosolic substrates by the lysosomal pathway. Cargoes destined to be eliminated are confined within double-membrane vesicles called autophagosomes, prior to fusion with endolysosomal vacuoles. Autophagy receptors selectively interact with cargoes and route them to elongating autophagic membranes, a process referred
Viret, Christophe +4 more
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Structure biology of selective autophagy receptors [PDF]
BMB Reports, 2016 Autophagy is a process tightly regulated by various autophagy-related proteins. It is generally classified into non-selective and selective autophagy. Whereas non-selective autophagy is triggered when the cell is under starvation, selective autophagy is involved in eliminating dysfunctional organelles, misfolded and/or ubiquitylated proteins, and ...
Kim, Byeong-Won +2 more
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Orchestration of selective autophagy by cargo receptors
Current Biology, 2022 Cellular homeostasis requires the swift and specific removal of damaged material. Selective autophagy represents a major pathway for the degradation of such cargo material. This is achieved by the sequestration of the cargo within double-membrane vesicles termed autophagosomes, which form de novo around the cargo and subsequently deliver their content ...
Adriaenssens, Elias +2 more
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Prostate cancer targeting using replication-selective adenoviruses in combination with phytochemicals [PDF]
, 2009 PhD 2009 QMOncolytic adenoviral mutants have demonstrated good safety profiles but, despite some encouraging clinical results, efficacy as a single agent was limited. Combinations with conventional chemo- or radiotherapy significantly enhanced the anti-
Adam, Virginie Sarah
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