Results 91 to 100 of about 298,238 (306)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Selective uptake of glutamine in the gastrointestinal tract [PDF]

Journal of British Surgery, 1992
N E P Deutz, S Heeneman, H M H Van Eijk, C H C Dejong, W J H J Meyerink, R R W J Van der Hulst, P B Soeters, M F Von Meyenfeldt   +7 more
openaire   +3 more sources

O envolvimento dos transportadores de monoaminas na captação de serotonina em veias [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaA serotonina (5-HT) é um neurotransmissor que está amplamente distribuído nos principais sistemas fisiológicos e ...
De Prá, Manuel Adalberto Alfaro
core  

Probucol Enhances Selective Uptake of HDL-Associated Cholesteryl Esters In Vitro by a Scavenger Receptor B-I–Dependent Mechanism

, 1999
—Recently, the class B, type I scavenger receptor (SR-BI) has been shown to mediate the selective uptake of high density lipoprotein (HDL) cholesteryl esters (CEs), ie, lipid uptake independent of HDL holoparticle uptake.
Rajasekhar Ramakrishnan, Nan Wang, Xian Cheng Jiang, Franz Rinninger, Alan R. Tall   +4 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Scavenger receptor CD36 mediates uptake of high density lipoproteins in mice and by cultured cells[S]

Journal of Lipid Research, 2011
The mechanisms of HDL-mediated cholesterol transport from peripheral tissues to the liver are incompletely defined. Here the function of scavenger receptor cluster of differentiation 36 (CD36) for HDL uptake by the liver was investigated.
May Brundert, Joerg Heeren, Martin Merkel, Antonella Carambia, Johannes Herkel, Peter Groitl, Thomas Dobner, Rajasekhar Ramakrishnan, Kathryn J. Moore, Franz Rinninger   +9 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Computational approaches for the prediction of the selective uptake of magnetofluorescent nanoparticles into human cells

, 2016
The use of functionalized nanomaterials is of high importance in biomedical applications like the efficient targeting of cancer cells. This paper proposes a comparison of different statistical and mechanistic aspects of new QSAR models generated to ...
PAPA, ESTER, Doucet, J. P., Doucet Panaye, A.   +2 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Effects of the selective norepinephrine uptake inhibitor nisoxetine on prodynorphin gene expression in rat CNS

, 2004
Cocaine binds to dopamine (DA), serotonin (5-HT) and norepinephrine (NE) transporters blocking the reuptake of these monoamines into presynaptic terminals.
Feliciani, Denise, CANDELETTI, SANZIO, FELICIANI D., D'Addario, Claudio, IZENWASSER S., DADDARIO C., ROMUALDI, PATRIZIA, DI BENEDETTO, MANUELA, Izenwasser, Sari   +8 more
core   +2 more sources