Results 81 to 90 of about 618,272 (309)

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Matrix-free calcium in isolated chromaffin vesicles [PDF]

, 1985
Isolated secretory vesicles from bovine adrenal medulla contain 80 nmol of Ca2+ and 25 nmol of Mg2+ per milligram of protein. As determined with a Ca2+-selective electrode, a further accumulation of about 160 nmol of Ca2+/mg of protein can be attained ...
Bashford L. C., Borowitz J. L., Borowitz J. L., Bradford M., Coll K. E., Debono M., Department of Biochemistry, Flodgaard H., Gratzl M., Grinstein S., Hansford R. G., Johnson R. G., Joseph S. K., Knight D. E., Krieger-Brauer H., Krieger-Brauer H., Krieger-Brauer H., Lowry O. H., MacLennan D. M., Nordmann J. J., Pfeiffer D. R., Pfeiffer D. R., Phillips J. H., Phillips J. H., Pollard B., Pollard B., Ravazzola M., Reed P. W., Reed P. W., Reinhart P. H., Saermark T., Saermark T., Serck-Hanssen G., Sillen L. G., Simon W., Wada A.   +35 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Quantitative analysis of SR-BI-dependent HDL retroendocytosis in hepatocytes and fibroblasts

Journal of Lipid Research, 2006
Previous studies have suggested that HDL retroendocytosis may play a role in scavenger receptor class B type I (SR-BI)-dependent selective lipid uptake in a cell-specific manner.
Bing Sun, Erik R.M. Eckhardt, Shoba Shetty, Deneys R. van der Westhuyzen, Nancy R. Webb   +4 more
doaj   +1 more source

Structural basis of ligand binding modes of human EAAT2

Nature Communications, 2022
Excitatory amino acid transporter 2 (EAAT2) mediates glutamate uptake in the synapse. Here, authors report cryo-EM structures of the human EAAT2 in complexes with glutamate or selective inhibitor WAY-213613, revealing important insights into substrate ...
Zhenglai Zhang, Huiwen Chen, Ze Geng, Zhuoya Yu, Hang Li, Yanli Dong, Hongwei Zhang, Zhuo Huang, Juquan Jiang, Yan Zhao   +9 more
doaj   +1 more source

Enhancing the cellular uptake of Py–Im polyamides through next-generation aryl turns [PDF]

, 2012
Pyrrole–imidazole (Py–Im) hairpin polyamides are a class of programmable, sequence-specific DNA binding oligomers capable of disrupting protein–DNA interactions and modulating gene expression in living cells.
Baird, Belitsky, Best, Bijsterbosch, Bradford, Chenoweth, Chenoweth, Chenoweth, Cleutjens, Cohen, Crowley, David C. Montgomery, Dervan, Dervan, Dickinson, Dose, D’Adamio, Edelson, Edwards, Gissot, Herman, Hesselberth, Hsu, Hsu, Jacobs, Johnson, Jordan L. Meier, Krutzik, Kwon, Magee, Mapp, Matsuda, Meijsing, Mrksich, Muzikar, Nickols, Nickols, Nickols, Nishijima, Ohtsukia, Olenyuk, Peter B. Dervan, Poulin-Kerstien, Reddy, Riegman, Rucker, Schmidt, Schultz, So, Swalley, Tsai, Van Dyke, Vaquerizas, Vichai, Yao   +54 more
core   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Regulation of SR-BI-mediated selective lipid uptake in Chinese hamster ovary-derived cells by protein kinase signaling pathwayss⃞

Journal of Lipid Research, 2007
Scavenger receptor, class B, type I (SR-BI) mediates binding and internalization of a variety of lipoprotein and nonlipoprotein ligands, including HDL.
Yi Zhang, Ayesha M. Ahmed, Nicole McFarlane, Christina Capone, Douglas R. Boreham, Ray Truant, Suleiman A. Igdoura, Bernardo L. Trigatti   +7 more
doaj   +1 more source