Results 111 to 120 of about 622,888 (291)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain [PDF]

, 2007
Little is known about the molecular basis of somatosensory mechanotransduction in mammals. We screened a library of peptide toxins for effects on mechanically activated currents in cultured dorsal root ganglion neurons.
Abrahamsen, B, Bowden, S, Brust, A, Cesare, P, Colless, B, Drew, LJ, Gale, JE, Heinzmann, S, Lewis, RJ, Robinson, M, Rugiero, F, Wood, JN   +11 more
core  

[Selective serotonin uptake inhibitors and pancreatitis].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2001
About 2% of all cases of pancreatitis are drug-induced. Several drugs cause pancreatitis, including selective serotonin reuptake inhibitors (SSRIs).Two Norwegian adverse drug event reports and a review of the international WHO adverse drug reactions database form the basis for this discussion.
K T, Kvande, S, Madsen
openaire   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Hepatic lipase deficiency decreases the selective uptake of HDL-cholesteryl esters in vivo

Journal of Lipid Research, 2000
Recent in vitro studies have provided evidence that hepatic lipase (HL) facilitates the selective uptake of HDL cholesteryl esters (CE), but the in vivo physiological relevance of this process has not been demonstrated. To evaluate the role that HL plays
Gilles Lambert, Marcelo J.A. Amar, Pascal Martin, Jamila Fruchart-Najib, Bernhard Föger, Robert D. Shamburek, H. Bryan Brewer, Jr., Silvia Santamarina-Fojo   +7 more
doaj   +1 more source

Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1. [PDF]

Nat Struct Mol Biol, 2023
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S.   +4 more
europepmc   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

A Warburg effect targeting vector designed to increase the uptake of compounds by cancer cells demonstrates glucose and hypoxia dependent uptake.

PLoS ONE, 2019
Glycoconjugation to target the Warburg effect provides the potential to enhance selective uptake of anticancer or imaging agents by cancer cells. A Warburg effect targeting group, rationally designed to facilitate uptake by glucose transporters and ...
Alexandra Glenister, Michela I Simone, Trevor W Hambley   +2 more
doaj   +1 more source

HDL modification by secretory phospholipase A2 promotes scavenger receptor class B type I interaction and accelerates HDL catabolism

Journal of Lipid Research, 2000
During inflammatory states plasma levels of high density lipoprotein (HDL) cholesterol and apolipoprotein A-I (apoA-I) are reduced. Secretory group IIa phospholipase A2 (sPLA2) is a cytokine-induced acute-phase enzyme associated with HDL. Transgenic mice
Frederick C. de Beer, Patrice M. Connell, J. Yu, Maria C. de Beer, Nancy R. Webb, Deneys R. van der Westhuyzen   +5 more
doaj   +1 more source

Good's Buffer Based Highly Biocompatible Ionic Liquid Modified PLGA Nanoparticles for the Selective Uptake in Cancer Cells. [PDF]

Mater Chem Front, 2023
Singh G, Dasanayake GS, Chism CM, Vashisth P, Kaur A, Misra SK, Sharp JS, Tanner EEL.   +7 more
europepmc   +1 more source