Results 101 to 110 of about 20,846 (213)

UGA codon position-dependent incorporation of selenocysteine into mammalian selenoproteins [PDF]

, 2013
It is thought that the SelenoCysteine Insertion Sequence (SECIS) element and UGA codon are sufficient for selenocysteine (Sec) insertion. However, we found that UGA supported Sec insertion only at its natural position or in its close proximity in ...
Gladyshev, Vadim N., Hatfield, Dolph L., Lobanov, Alexei V., Turanov, Anton A.   +3 more
core   +1 more source

The C-terminal selenenylsulfide of extracellular/non-reduced thioredoxin reductase endows this protein with selectivity to small-molecule electrophilic reagents under oxidative conditions

Frontiers in Molecular Biosciences
Mammalian cytosolic thioredoxin reductase (TrxR1) serves as an antioxidant protein by transferring electrons from NADPH to various substrates. The action of TrxR1 is achieved via reversible changes between NADPH-reduced and non-reduced forms, which ...
Huijun Qin, Chenchen Guo, Bozhen Chen, Hui Huang, Yaping Tian, Liangwei Zhong   +5 more
doaj   +1 more source

Solution Structures of \u3cem\u3eMycobacterium tuberculosis\u3c/em\u3e Thioredoxin C and Models of Intact Thioredoxin System Suggest New Approaches to Inhibitor and Drug Design [PDF]

, 2013
Here, we report the NMR solution structures of Mycobacterium tuberculosis (M. tuberculosis) thioredoxin C in both oxidized and reduced states, with discussion of structural changes that occur in going between redox states.
Cai, Sheng, Neumann, Terrence S., Olson, Andrew Lawrence, Sem, Daniel S.   +3 more
core   +1 more source

Selenium induced selenocysteine methyltransferase gene expression and antioxidant enzyme activities in Astragalus chrysochlorus [PDF]

, 2016
Astragalus sp. are used in folk medicine because of their biological activities and are known for the ability to accumulate high levels of selenium (Se).
Neslihan Turgut-Kara, Özgür Çakir, Şule Ari   +2 more
core   +2 more sources

Foliar selenium biofortification of soybean: the potential for transformation of mineral selenium into organic forms

Frontiers in Plant Science
IntroductionSelenium (Se) deficiency, stemming from malnutrition in humans and animals, has the potential to disrupt many vital physiological processes, particularly those reliant on specific selenoproteins.
Tomáš Mrština, Lukáš Praus, Jiřina Száková, Lukáš Kaplan, Pavel Tlustoš   +4 more
doaj   +1 more source

Evaluation of SEPP1 and Selenoprotein S Gene Polymorphisms (rs7579 and rs34713741) in Relation to Colorectal Cancer Susceptibility in Subset of Iranian Population: A Case–control Study

Advanced Biomedical Research, 2019
Background: Colorectal cancer (CRC) is rated as the second cause of cancer death worldwide. Selenium (Se) has antioxidant activity and antitumor effect, especially in colon cancer. This important role occurs through selenoproteins.
Guilda Amini, Rasoul Salehi, Ali Asghar Moshtaghi, Mohammad Kazemi, Mohaddeseh Behjati, Sharifeh Khosravi   +5 more
doaj   +1 more source

On the road to selenocysteine [PDF]

Proceedings of the National Academy of Sciences, 2004
Decades ago, a mammalian tRNA that exclusively bound the UGA stop codon was identified by using the triplet binding assay that was instrumental in deciphering the genetic code (1). The possibility of a naturally occurring suppressor tRNA presented the dilemma of explaining the biological function of such a molecule.
openaire   +2 more sources

Defining the methanogenic SECIS element in vivo by targeted mutagenesis

RNA Biology
In all domains of life, Archaea, Eukarya and Bacteria, the unusual amino acid selenocysteine (Sec) is co-translationally incorporated into proteins by recoding a UGA stop codon to a sense codon.
Nils Peiter, Anna Einert, Pauline Just, Frida Jannasch, Marija Najdovska, Michael Rother   +5 more
doaj   +1 more source

Selenoproteins in mammalian spermatogenesis:role of the nuclear GPx4 [PDF]

, 2011
The selenoprotein Phospholipid Hydroperoxide Glutathione Peroxidase (PHGPx/GPx4) is an enzyme unique among the various GPxs, because it is able to use protein thiols, beside glutathione, The GPx4 gene encodes for three isoforms having different ...
Maccari, Irene
core  

The role of selenium in nutrition – A review

Acta Universitatis Sapientiae: Alimentaria, 2018
The role of selenium has been changed over the last decade. The element that was previously considered to be toxic turned out to be present in the human body in amounts of 10–15 mg, and almost every cell of our body contains it.
Tóth R. Juhászné, Csapó J.
doaj   +1 more source