Biofortification of UK food crops with selenium [PDF]
, 2006 Se is an essential element for animals. In man low dietary Se intakes are associated with health disorders including oxidative stress-related conditions, reduced fertility and immune functions and an increased risk of cancers.
Bell +34 more
core +3 more sources
Selenium-Binding Protein 1 Indicates Myocardial Stress and Risk for Adverse Outcome in Cardiac Surgery [PDF]
, 2019 Selenium-binding protein 1 (SELENBP1) is an intracellular protein that has been detected in the circulation in response to myocardial infarction. Hypoxia and cardiac surgery affect selenoprotein expression and selenium (Se) status.
Kühn, Eike C. +8 more
core +1 more source
Effects of selenium biofortification on crop nutritional quality [PDF]
, 2015 Selenium (Se) at very low doses has crucial functions in humans and animals. Since plants represent the main dietary source of this element, Se-containing crops may be used as a means to deliver Se to consumers (biofortification). Several strategies have
Dall'Acqua, Stefano +3 more
core +1 more source
Expression of a catalytically inactive mutant form of glutathione peroxidase 4 (Gpx4) confers a dominant-negative effect in male fertility. [PDF]
, 2015 The selenoenzyme Gpx4 is essential for early embryogenesis and cell viability for its unique function to prevent phospholipid oxidation. Recently, the cytosolic form of Gpx4 was identified as an upstream regulator of a novel form of non-apoptotic cell ...
Aichler, M +12 more
core +1 more source
Regulation of Redox Signaling by Selenoproteins [PDF]
, 2010 The unique chemistry of oxygen has been both a resource and threat for life on Earth for at least the last 2.4 billion years. Reduction of oxygen to water allows extraction of more metabolic energy from organic fuels than is possible through anaerobic ...
Wayne Chris Hawkes, Zeynep Alkan
core +1 more source
Halving the selenophosphate synthetase gene dose confers hypersensitivity to oxidative stress in Drosophila melanogaster [PDF]
, 2003 Several lines of evidence indicate that selenoproteins mainly act as cellular antioxidants. Here, we test this idea comparing the sensitivity to oxidative stress (paraquat and hydrogen peroxide) between wild type and heterozygous flies for the ...
Morey, Marta +2 more
core +1 more source
Selenoproteins and cardiovascular stress [PDF]
Thrombosis and Haemostasis, 2015 SummaryDietary selenium (Se) is an essential micronutrient that exerts its biological effects through its incorporation into selenoproteins. This family of proteins contains several antioxidant enzymes such as the glutathione peroxidases, redox-regulating enzymes such as thioredoxin reductases, a methionine sulfoxide reductase, and others.
Aaron H, Rose, Peter R, Hoffmann
openaire +2 more sources
Revisiting oxidative stress and the use of organic selenium in dairy cow nutrition [PDF]
, 2019 In commercial animal production productive stress can negatively impact health status and subseqeunt productive and reproductive performance. A great body of evidence demonstrates that as a conseuquence of productive stress an overproduction of free ...
Costa +16 more
core +1 more source
Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis [PDF]
, 2016 Selenium, an essential micronutrient known for its cancer prevention properties, is incorporated into a class of selenocysteine-containing proteins (selenoproteins).
Asara, John M. +18 more
core +1 more source
Selenium, Selenoproteins, and Immunity [PDF]
Nutrients, 2018 Selenium is an essential micronutrient that plays a crucial role in development and a wide variety of physiological processes including effect immune responses. The immune system relies on adequate dietary selenium intake and this nutrient exerts its biological effects mostly through its incorporation into selenoproteins. The selenoproteome contains 25
Joseph Avery, Peter Hoffmann
openaire +2 more sources