Results 91 to 100 of about 14,594 (219)

Plate cell – SELEX v2 [PDF]

, 2019
Aptamers are short single-stranded oligonucleotide (DNA or RNA) molecules with the ability to bind to other molecules with high affinity and specificity. Nowadays, aptamers are used as biosensing molecules with broader applications, such as ribozymes (RNA enzyme molecules with catalytic activities); riboswitches (modulating translational activities ...
openaire   +1 more source

SELEX Technologieentwicklung im Hochdurchsatz

, 2012
The SELEX process for the selection of functional nucleic acids (here: aptamers) is, although frequently modified, still a time and therefore cost- intensive process. A parallel and semiautomated selection of DNA aptamers in 10 rounds against Streptavidin was first conducted according to conventional protocols (cloning, Sanger sequencing), and then ...
openaire   +2 more sources

Sequence-based modeling of low-affinity transcription factor-DNA binding through deep learning. [PDF]

NAR Genom Bioinform
Wang Y, Li J, Chiu TP, Xin B, Rohs R.
europepmc   +1 more source

Selection of ssDNA aptamers targeting the serine protease SPSFQ of Acinetobacter baumannii and development of an electrochemical impedance spectroscopy-based ultrasensitive SPSFQ biosensor. [PDF]

Mikrochim Acta
Özyurt C, Afşar M, Ülker G, Man E, Evran S, Sezgintürk MK.   +5 more
europepmc   +1 more source

RaptScore: a large language model-based algorithm for versatile aptamer evaluation. [PDF]

Nucleic Acids Res
Kimura-Yamazaki A, Adachi T, Nakamura S, Nakamura Y, Hamada M.   +4 more
europepmc   +1 more source

Aptamer-Based Delivery of Genes and Drugs Across the Blood-Brain Barrier. [PDF]

Pharmaceuticals (Basel)
Yang L, Yin Y, Liu X, Guo B.
europepmc   +1 more source

Automated high-throughput selection of DNA aptamers using a common optical next-generation sequencer. [PDF]

Nucleic Acids Res
Drees A, Ahlers C, Kehrer T, Ehmke N, Grün AFR, Uetrecht C, Ignatova Z, Schumacher U, Fischer M.   +8 more
europepmc   +1 more source

Development of an impedimetric aptasensor for Shiga-like toxin 1 using a DNA aptamer and an interdigitated microelectrode. [PDF]

RSC Adv
Mili M, Chinnadayyala SR, Cho S, Goswami P.   +3 more
europepmc   +1 more source

Enriching Higher Affinity Aptamers by Addressing the Kinetic Aspect of the DNA Strand-Displacement Reaction. [PDF]

Angew Chem Int Ed Engl
Ding Y, Heng Y, Wong KY, Chen Q, Liu J.
europepmc   +1 more source

Affinity Maturation of a Fentanyl Aptamer by Motif-SELEX. [PDF]

JACS Au
Alkhamis O, Canoura J, Castro G, Byrd C, Bryant A, Yu H, Xiao Y.   +6 more
europepmc   +1 more source