Results 141 to 150 of about 14,594 (219)

Designing the Future of Biosensing: Advances in Aptamer Discovery, Computational Modeling, and Diagnostic Applications. [PDF]

Biosensors (Basel)
Jesky RG, Lo LHY, Siu RHP, Tanner JA.
europepmc   +1 more source

A Membrane-Retained DNA Aptamer Promotes Intracellular Platinum Accumulation and Chemosensitization in Ovarian Cancer. [PDF]

ACS Appl Mater Interfaces
Dong W, Xie W, Song K, Yuan Q, Xi P, Fan H, Ma L, Sun W, Zhang H, Tan W.   +9 more
europepmc   +1 more source

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Capture-SELEX for aptamer selection: A short review

Talanta, 2021
The emerging aptamer, developed through the systematic evolution of ligands by exponential enrichment (SELEX) process, has revolutionized and facilitated the discoveries in basic research.
Imran Mahmood Khan, Zhouping Wang
exaly   +2 more sources

Quantitative Comparison of Capture-SELEX, GO-SELEX, and Gold-SELEX for Enrichment of Aptamers.

Analytical Chemistry, 2023
Since 1990, numerous methods for aptamer selection have been developed, although a quantitative comparison of their sequence enrichment is lacking. In this study, we compared the enrichment factors of three library-immobilization SELEX methods (capture ...
Yuzhe Ding, Juewen Liu
semanticscholar   +3 more sources

Aptamer Nanoconstructs Crossing Human Blood–Brain Barrier Discovered via Microphysiological System-Based SELEX Technology

ACS Nano, 2023
Blood-brain barrier (BBB) remains one of the critical challenges in developing neurological therapeutics. Short single-stranded DNA/RNA nucleotides forming a three-dimensional structure, called aptamers, have received increasing attention as BBB shuttles
Joo H Kang, Jinmyoung Joo, Tae-Eun Park
exaly   +2 more sources

Capture-SELEX of DNA Aptamers for Estradiol Specifically and Estrogenic Compounds Collectively

Environmental Science & Technology, 2022
Estrogenic compounds such as estrone (E1), 17β-estradiol (E2), and 17α-ethynylestradiol (EE2) are serious environmental contaminants due to their potent biological activities. At least six selections were previously reported to obtain DNA aptamers for E2,
Chong Zhang, Juewen Liu, 刘珏文
exaly   +2 more sources

Strategies to manipulate the performance of aptamers in SELEX, post-SELEX and microenvironment.

Biotechnology Advances, 2022
Aptamers are short single-stranded DNA or RNA oligonucleotides isolated from randomized libraries, presenting high affinity and specificity toward targets with similar to antibodies.
Shuo Qi, Nuo Duan, I. Khan, Xiaoze Dong, Yin Zhang, Shijia Wu, Zhouping Wang   +6 more
semanticscholar   +3 more sources

Recent progress of SELEX methods for screening nucleic acid aptamers.

Talanta: The International Journal of Pure and Applied Analytical Chemistry, 2023
Nucleic acid aptamers are oligonucleotide sequences screened by an in vitro methodology called Systematic Evolution of Ligands by Exponential Enrichment (SELEX).
Chao Zhu, Ziru Feng, Hongwei Qin, Lu Chen, Mengmeng Yan, Linsen Li, Feng Qu   +6 more
semanticscholar   +1 more source

Complex Target SELEX

Accounts of Chemical Research, 2008
Aptamers are non-naturally occurring structured oligonucleotides that may bind to small molecules, peptides, and proteins. Typically, aptamers are generated by an in vitro selection process referred to as SELEX (systematic evolution of ligands by exponential enrichment).
Steven M, Shamah, Judith M, Healy, Sharon T, Cload   +2 more
exaly   +3 more sources

Pushing Adenosine and ATP SELEX for DNA Aptamers with Nanomolar Affinity.

Journal of the American Chemical Society, 2023
The classical DNA aptamer for adenosine and ATP has been the most used small molecule binding aptamer for biosensing, imaging, and DNA nanotechnology. This sequence has recurred multiple times in previous aptamer selections, and all previous selections ...
Yuzhe Ding, Juewen Liu
semanticscholar   +1 more source