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Design and application of microfluidics in aptamer SELEX and Aptasensors.
Biotechnology AdvancesAptamers are excellent recognition molecules obtained from systematic evolution of ligands by exponential enrichment (SELEX) that have been extensively researched for constructing aptasensors.
Shikun Zhang +7 more
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Biosensors & bioelectronics
Aptamers, as a kind of recognition molecules with stable nature and excellent binding ability, are usually obtained by systematic evolution of ligands by exponential enrichment (SELEX).
Shikun Zhang +6 more
semanticscholar +1 more source
Aptamers, as a kind of recognition molecules with stable nature and excellent binding ability, are usually obtained by systematic evolution of ligands by exponential enrichment (SELEX).
Shikun Zhang +6 more
semanticscholar +1 more source
A Computational Study of Alternate SELEX
Bulletin of Mathematical Biology, 2014Systematic evolution of ligands by exponential enrichment (SELEX) is a procedure for identifying nucleic acid (NA) molecules with affinities for specific target species, such as proteins, peptides, or small organic molecules. Here, we extend the work in Seo et al. (Bull Math Biol 72:1623-1665, 2010) (multiple-target SELEX or positive SELEX) and examine
Seo, Yeon-Jung +2 more
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2009 International Symposium on Micro-NanoMechatronics and Human Science, 2009
The pattern of genome transcription in prokaryotes is determined by selective distribution of RNA polymerase within the genome. The gene selectivity of RNA polymerase is modulated after interaction with DNA-binding transcription factors (TFs). Escherichia coli contains a total of about 300 TFs, but the regulatory function has not yet been identified ...
Tomohiro Shimada +3 more
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The pattern of genome transcription in prokaryotes is determined by selective distribution of RNA polymerase within the genome. The gene selectivity of RNA polymerase is modulated after interaction with DNA-binding transcription factors (TFs). Escherichia coli contains a total of about 300 TFs, but the regulatory function has not yet been identified ...
Tomohiro Shimada +3 more
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Proceedings of the 14th Conference on Pattern Languages of Programs, 2007
State machine specifications and their implementations are often complex because they have many responsibilities mixed together. A potential cause for responsibility clutter is message multiplexing, which means that one or more incoming and/or outgoing messages of the state machine contain data that belongs to different concerns.
Frank Roessler, Birgit Geppert
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State machine specifications and their implementations are often complex because they have many responsibilities mixed together. A potential cause for responsibility clutter is message multiplexing, which means that one or more incoming and/or outgoing messages of the state machine contain data that belongs to different concerns.
Frank Roessler, Birgit Geppert
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SELEX experiment (Fermilab E781)
AIP Conference Proceedings, 1998The poster presents the physics goals and experimental status of Selex (Segmented Large X Spectrometer), supported by many international institutions which has been taking data since February 1997. The principal goal of this experiment is to have a high statistics sample of charm baryons from 650 GeV Σ− and π− beams.
Fernanda G. Garcia, Jurgen Simon
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Developing Aptamers by Cell-Based SELEX
2016The reliable targeting of cell surface disease-associated proteins is a major challenge in chemical biology and molecular medicine. In this regard, aptamers represent a very attractive and innovative class of ligand molecules. Aptamers are generated by a reiterated in vitro procedure, named SELEX (Systematic Evolution of Ligands by Exponential ...
Catuogno S, Esposito CL, de Franciscis V
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Combinatorial Chemistry of Nucleic Acids: SELEX
Molecular Biology, 2000A method of irrational oligonucleotide design, SELEX, is considered. Individual SELEX products, aptamers, are small molecules (40–100 nt) that have a unique three-dimensional structure, which provides for their specific and high-affinity binding to targets varying from low-molecular-weight ligands to proteins.
A M, Kopylov, V A, Spiridonova
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Multifaceted arsenal in SELEX nanomedicine
Advances in Colloid and Interface ScienceAptamers, short oligonucleotide sequences that bind specifically to cellular proteins and receptors, are emerging as versatile tools in molecular nanomedicine. Unlike passive tumor targeting via the enhanced permeability and retention (EPR) effect, aptamers enable precise drug delivery, enhancing therapeutic efficacy while minimizing side effects ...
Oishika, Chatterjee +6 more
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