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Genomic SELEX for the genome-wide search of regulation targets by transcription factors: SELEX-clos and SELEX-chip procedures

2009 International Symposium on Micro-NanoMechatronics and Human Science, 2009
The pattern of genome transcription in prokaryotes is determined by selective distribution of RNA polymerase within the genome. The gene selectivity of RNA polymerase is modulated after interaction with DNA-binding transcription factors (TFs). Escherichia coli contains a total of about 300 TFs, but the regulatory function has not yet been identified ...
Tomohiro Shimada   +3 more
openaire   +1 more source

The Selex design pattern

Proceedings of the 14th Conference on Pattern Languages of Programs, 2007
State machine specifications and their implementations are often complex because they have many responsibilities mixed together. A potential cause for responsibility clutter is message multiplexing, which means that one or more incoming and/or outgoing messages of the state machine contain data that belongs to different concerns.
Frank Roessler, Birgit Geppert
openaire   +1 more source

SELEX experiment (Fermilab E781)

AIP Conference Proceedings, 1998
The poster presents the physics goals and experimental status of Selex (Segmented Large X Spectrometer), supported by many international institutions which has been taking data since February 1997. The principal goal of this experiment is to have a high statistics sample of charm baryons from 650 GeV Σ− and π− beams.
Fernanda G. Garcia, Jurgen Simon
openaire   +1 more source

Developing Aptamers by Cell-Based SELEX

2016
The reliable targeting of cell surface disease-associated proteins is a major challenge in chemical biology and molecular medicine. In this regard, aptamers represent a very attractive and innovative class of ligand molecules. Aptamers are generated by a reiterated in vitro procedure, named SELEX (Systematic Evolution of Ligands by Exponential ...
Catuogno S, Esposito CL, de Franciscis V
openaire   +4 more sources

Combinatorial Chemistry of Nucleic Acids: SELEX

Molecular Biology, 2000
A method of irrational oligonucleotide design, SELEX, is considered. Individual SELEX products, aptamers, are small molecules (40–100 nt) that have a unique three-dimensional structure, which provides for their specific and high-affinity binding to targets varying from low-molecular-weight ligands to proteins.
A M, Kopylov, V A, Spiridonova
openaire   +2 more sources

Multifaceted arsenal in SELEX nanomedicine

Advances in Colloid and Interface Science
Aptamers, short oligonucleotide sequences that bind specifically to cellular proteins and receptors, are emerging as versatile tools in molecular nanomedicine. Unlike passive tumor targeting via the enhanced permeability and retention (EPR) effect, aptamers enable precise drug delivery, enhancing therapeutic efficacy while minimizing side effects ...
Oishika, Chatterjee   +6 more
openaire   +2 more sources

SELEX

2022
Chenxi Liang, Peixuan Guo
openaire   +1 more source

Capture-SELEX for aptamer selection: A short review

Talanta, 2021
Imran Mahmood Khan, Zhouping Wang
exaly  

SELEX in silico

2013
Poster Presentations: Theme 1 - Cancer: abstract no.
Tanner, JA, Kinghorn, A
openaire   +1 more source

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