Results 171 to 180 of about 19,390 (205)

Pushing Adenosine and ATP SELEX for DNA Aptamers with Nanomolar Affinity.

Journal of the American Chemical Society, 2023
The classical DNA aptamer for adenosine and ATP has been the most used small molecule binding aptamer for biosensing, imaging, and DNA nanotechnology. This sequence has recurred multiple times in previous aptamer selections, and all previous selections ...
Yu-Zhe Ding, Jue-Wen Liu
semanticscholar   +1 more source

Aptamer Nanoconstructs Crossing Human Blood-Brain Barrier Discovered via Microphysiological System-Based SELEX Technology.

ACS Nano, 2023
Blood-brain barrier (BBB) remains one of the critical challenges in developing neurological therapeutics. Short single-stranded DNA/RNA nucleotides forming a three-dimensional structure, called aptamers, have received increasing attention as BBB shuttles
Jeong-Won Choi, Minwook Seo, Kyunghwan Kim, A‐Ru Kim, H. Lee, Hyungmin Kim, Chun Gwon Park, Woo-Cho Seung, Joo H. Kang, Jinmyoung Joo, Tae-Eun Park   +10 more
semanticscholar   +1 more source

Multiplexed SELEX for Sulfonamide Antibiotics Yielding a Group-Specific DNA Aptamer for Biosensors.

Analytical Chemistry, 2023
The widespread use of sulfonamide (SA) antibiotics in animal husbandry has led to residues of SAs in the environment, causing adverse effects to the ecosystem and a risk of bacterial resistance, which is a potential threat to public health. Therefore, it
Xiangmei Li, Ze-Hao Yang, Michelle Waniss, Xiaohua Liu, Xiaoqin Wang, Zhenlin Xu, Hongtao Lei, Jue-Wen Liu   +7 more
semanticscholar   +1 more source

Development of Cell-SELEX Technology and Its Application in Cancer Diagnosis and Therapy

International Journal of Molecular Sciences, 2016
SELEX (systematic evolution of ligands by exponential enrichment) is a process involving the progressive isolation of high selective ssDNA/RNA from a combinatorial single-stranded oligonucleotide library through repeated rounds of binding, partitioning ...
Lü Aiping, Chao Liang, Ge Zhang
exaly   +2 more sources

Strategies to manipulate the performance of aptamers in SELEX, post-SELEX and microenvironment.

Biotechnology Advances, 2022
Aptamers are short single-stranded DNA or RNA oligonucleotides isolated from randomized libraries, presenting high affinity and specificity toward targets with similar to antibodies.
Shuo Qi, Nuo Duan, I. Khan, Xiaoze Dong, Yin Zhang, Shi-Jia Wu, Zhouping Wang   +6 more
semanticscholar   +1 more source

Three-step evolutionary enhanced capillary electrophoresis-SELEX for aptamer selection of exosome vesicles.

Talanta: The International Journal of Pure and Applied Analytical Chemistry, 2023
As various disease biomarkers, drugs/biomolecules carriers and physiological function regulator, exosomes play significant roles in various physiological and pathological process.
Liping Zhao, Ge Yang, Chao Zhu, Linsen Li, Yi Zhao, Yunxia Luan, Feng Qu   +6 more
semanticscholar   +1 more source

Non-immobilized GO-SELEX of aptamers for label-free detection of thiamethoxam in vegetables.

Analytica Chimica Acta, 2022
Due to the massive use of thiamethoxam (TMX) pesticide and the accumulated potential hazards exposure, the detection of TMX is of great significance to food and ecological safety.
Qian-Qian Kong, Feng-Li Yue, Mengyue Liu, Jingcheng Huang, Fengzhen Yang, Junjie Liu, Jiansen Li, Falan Li, Xia Sun, Ye-Min Guo, Yelong Zhu   +10 more
semanticscholar   +1 more source

Capture-SELEX of DNA Aptamers for Estradiol Specifically and Estrogenic Compounds Collectively.

Environmental Science and Technology, 2022
Estrogenic compounds such as estrone (E1), 17β-estradiol (E2), and 17α-ethynylestradiol (EE2) are serious environmental contaminants due to their potent biological activities. At least six selections were previously reported to obtain DNA aptamers for E2,
Chenqi Niu, Chong Zhang, Jue-Wen Liu
semanticscholar   +1 more source

In silico SELEX screening and statistical analysis of newly designed 5mer peptide-aptamers as Bcl-xl inhibitors using the Taguchi method

Comput. Biol. Medicine, 2022
Drug development for cancer treatment is a complex process that requires special efforts. Targeting crucial proteins is the most essential purpose of drug design in cancers.
Alireza Poustforoosh, Sanaz Faramarz, M. Nematollahi, H. Hashemipour, M. Negahdaripour, A. Pardakhty   +5 more
semanticscholar   +1 more source

GO-SELEX-enhanced dual-recognition sensor for highly specific detection of azamethiphos.

Journal of Hazardous Materials
Organophosphorus pesticides (OPs) have attracted attention due to their widespread application in agriculture and public health sector. Among them, azamethiphos (AZA) may pose risks to non-target organisms and human health through food chain accumulation.
Ling-Jun Geng, Jingcheng Huang, Haowei Dong, Hai-Fang Wang, Rui Xu, Zhiping Yu, I. Darwish, Ye-Min Guo, Xia Sun   +8 more
semanticscholar   +1 more source