Results 161 to 170 of about 6,782 (204)

Mixed squaramide thioesters as phosphate group analogues for non-competitive antagonists of the phospholipid-sensing G protein-coupled receptor GPR55. [PDF]

RSC Chem Biol
Abe J, Huang X, Ishii N, Imayoshi I, Hirabayashi Y, Matsuo I, Kamiguchi H, Ito Y, Guy AT, Greimel P.   +9 more
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Sema3A regulates bone-mass accrual through sensory innervations

Nature, 2013
Semaphorin 3A (Sema3A) is a diffusible axonal chemorepellent that has an important role in axon guidance. Previous studies have demonstrated that Sema3a(-/-) mice have multiple developmental defects due to abnormal neuronal innervations. Here we show in mice that Sema3A is abundantly expressed in bone, and cell-based assays showed that Sema3A affected ...
Toru Fukuda, Shu Takeda, Ren Xu
exaly   +3 more sources

The possible involvement of sema3A and sema4A in the pathogenesis of multiple sclerosis

Clinical Immunology, 2022
Immune semaphorins are widely accepted to have functional impact on autoimmune diseases.To assess the status of sema3A and sema4A in the pathogenesis of Multiple Sclerosis (MS).Sema3A expression on (T regulatory cells)Tregs was decreased in MS patients, compared to healthy controls (35.85 ± 16.7% vs 88.27 ± 3.8%; p ≤ 0.001). Serum levels of sema3A were
N, Eiza, M, Garty, E, Staun-Ram, A, Miller, Z, Vadasz   +4 more
openaire   +2 more sources

Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging [PDF]

Cell Metabolism, 2019
Osteocyte survival is key to bone homeostasis and is perturbed in menopause and aging. However, it remains unknown how osteocyte-mediated maintenance of the skeleton is regulated by the osteoprotective factor semaphorin 3A (Sema3A), a secreted protein that is known to reduce bone resorption and enhance bone formation.
Mikihito Hayashi, Tomoki Nakashima, Noriko Yoshimura   +2 more
exaly   +3 more sources

The role of Wnt, ARL4C, and Sema3A in developmental process and disease pathogenesis

Pathology International, 2023
AbstractVarious types of tumors, including malignant and benign ones, occur in the oral cavity. These arise from the mucosal epithelium, odontogenic epithelium, and salivary gland. To date, few major driver events in oral tumors have been identified. Accordingly, molecular targets in anti‐tumor therapy for oral tumors are lacking.
Shinsuke Fujii, Tamotsu Kiyoshima
openaire   +2 more sources

Sema3A maintains corneal avascularity during development by inhibiting Vegf induced angioblast migration

Developmental Biology, 2014
Corneal avascularity is important for optical clarity and normal vision. However, the molecular mechanisms that prevent angioblast migration and vascularization of the developing cornea are not clear.
James Spurlin, Peter Y Lwigale
exaly   +2 more sources

FARP2 triggers signals for Sema3A-mediated axonal repulsion

Nature Neuroscience, 2005
Sema3A, a prototypical semaphorin, acts as a chemorepellent or a chemoattractant for axons by activating a receptor complex comprising neuropilin-1 as the ligand-binding subunit and plexin-A1 as the signal-transducing subunit. How the signals downstream of plexin-A1 are triggered upon Sema3A stimulation, however, is unknown.
Toshihiko, Toyofuku, Junko, Yoshida, Tamiko, Sugimoto, Hong, Zhang, Atsushi, Kumanogoh, Masatsugu, Hori, Hitoshi, Kikutani   +6 more
openaire   +2 more sources

Developmentally regulated expression of Sema3A chemorepellant in the developing mouse incisor

Acta Odontologica Scandinavica, 2011
Semaphorin 3A (Sema3A) is an essential chemorepellant controlling peripheral axon pathfinding and patterning, but also serves non-neuronal cellular functions. Incisors of rodent are distinctive from molars as they erupt continuously, have only one root and enamel is present only on the labial side.
Kyaw, Moe, Anjana, Shrestha, Inger Hals, Kvinnsland, Keijo, Luukko, Päivi, Kettunen   +4 more
openaire   +2 more sources

SEMA3A as a biomarker of primary ventricular fibrillation complicating STEMI

Heart Rhythm
No abstract ...
Clément Boiteux, Simon Leboube, Ahmad Hayek, Camille Brun, Francis Bessiere, Nathan Mewton, Gabriel Bidaux, Claire Crola Da Silva, Philippe Chevalier, Thomas Bochaton   +9 more
openaire   +4 more sources

SEMA3A regulates developing sensory projections in the chicken spinal cord

Journal of Neurobiology, 2000
The present study explores the role of SEMA3A (collapsin-1) in the temporal and spatial regulation of developing sensory projections in the chick spinal cord. During development, SEMA3A mRNA (SEMA3A) is first expressed throughout the spinal gray matter, but disappears from the dorsal region when small caliber (trkA(+)) sensory axon collaterals first ...
S Y, Fu, K, Sharma, Y, Luo, J A, Raper, E, Frank   +4 more
openaire   +2 more sources