Results 161 to 170 of about 2,835 (194)

Proteomic Signatures of Cardiac Dysfunction Among People With Diabetes: The Atherosclerosis Risk in Communities Study. [PDF]

open access: yesCirc Heart Fail
Echouffo-Tcheugui JB   +21 more
europepmc   +1 more source

Asiaticoside alleviates lipopolysaccharide-induced acute lung injury by blocking Sema4D/CD72 and inhibiting mitochondrial dysfunction in RAW264.7 cell and mice. [PDF]

open access: yesNaunyn Schmiedebergs Arch Pharmacol
Zhang J   +11 more
europepmc   +1 more source

Involvement of Sema4D in the migration and morphology of murine microglia

open access: yesInvolvement of Sema4D in the migration and morphology of murine microglia
openaire  

The regulation of Sema4D exodomain shedding by protein kinase A in platelets

open access: yesPlatelets, 2016
We have previously shown that Sema4D expressed on the platelet plasma membrane can be cleaved by the metalloprotease ADAM17, producing a 120-kDa exodomain fragment that retains biological activity and remnant fragments of 24-28 kDa that remain associated with the platelet membrane. This process is modulated by calmodulin.
Lawrence F Brass, L Zhu
exaly   +3 more sources

Semaforin Sema4D in the Immune System in Multiple Sclerosis

Bulletin of Experimental Biology and Medicine, 2014
The expression of class IV semaforin Sema4D and its CD72 receptor on lymphocytes was studied in patients with multiple sclerosis. The disease was associated with an increase in Sema4D level on intact T lymphocytes and with its more intense shedding from the membrane of activated cell.
T V Baidina   +2 more
exaly   +3 more sources

Sema4D as a biomarker for Predicting rheumatoid arthritis disease activity

Clinical Rheumatology, 2023
The semaphorins are membrane or secreted proteins first identified in neural development. Semaphorin 4D (Sema4D) is the first family member found to have immune properties. We evaluated the potential of Sema4D as a marker for rheumatoid arthritis (RA) disease activity, singly and in combination with other known biomarkers including rheumatoid factor ...
Huiyuan Liu   +8 more
openaire   +2 more sources

Biological functions and signaling of a transmembrane semaphorin, CD100/Sema4D

Cellular and Molecular Life Sciences, 2004
The semaphorin proteins were identified originally as axonal guidance factors functioning during neuronal development. In addition to this function, several semaphorins play diverse roles outside the nervous system. The class 4 semaphorin CD100/Sema4D, which utilizes plexin-B1 and CD72 as receptors, exerts important biological effects on a variety of ...
A Kumanogoh, Hitoshi Kikutani
exaly   +3 more sources

Involvement of Sema4D in the control of microglia activation

Neurochemistry International, 2009
Microglia normally exist in a resting state characterized by a ramified morphology, and are responsible for immune surveillance in the CNS. However, the resting microglia rapidly transform towards an activated phenotype in response to brain injury or immunological stimuli.
Marcia, Toguchi   +3 more
openaire   +2 more sources

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