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Sema4D is required in both the adaptive and innate immune responses of contact hypersensitivity
Molecular Immunology, 2016Originally recognized as a regulator of axon guidance in the nervous system, Semaphorin 4D (Sema4D, CD100) also participates in various immune responses and many immune-related diseases. However, whether Sema4D is involved in the pathogenesis of contact hypersensitivity (CHS) remains unclear.
Zhenlai Zhu +11 more
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Sema4D Knockdown in Oligodendrocytes Promotes Functional Recovery After Spinal Cord Injury
Cell Biochemistry and Biophysics, 2013Semaphorin4D (Sema4D) belongs to Semaphorins family and is secreted and membrane-bound protein. Its function on angiogenesis and axon regeneration makes it an ideal therapeutic target for spinal cord injury (SCI). Here we examined Sema4D expression profile by real-time PCR and western blot and found Sema4D was upregulated after SCI.
Hong-Lei, Zhang, Jing, Wang, Long, Tang
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Isolating Fc-Tagged SEMA4D Recombinant Protein from 293FT Cells
2016Recombinant proteins are widely used in biomedical sciences, and in pharmaceutical research. Through genetic recombination, specific DNA sequences are engineered and inserted into a biological host. Once inside the host, the DNA is transcribed and translated into the target protein and is ready to be purified.
Joanne, Soong, Glynis A, Scott
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Identification of SEMA4D as a novel causal gene of idiopathic hypogonadotropic hypogonadism
European Urology, 2022D. Wang, Y. Niu, H. Xu, J. Liu
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Generation and preclinical characterization of an antibody specific for SEMA4D
MAbs, 2016Laurie A Winter +2 more
exaly