Results 171 to 180 of about 2,835 (194)

Involvement of Semaphorin (Sema4D) in T-Dependent Activation of B Cells

Bulletin of Experimental Biology and Medicine, 2017
The involvement of endogenous semaphorin (Sema4D) into the key stage of T-dependent differentiation of B cells, formation of plasmoblasts, was demonstrated in vitro in T/B cell co-culture under conditions of polyclonal activation of T cells. The effect of semaphorin was not associated with activation of high-affinity Sema4D receptor plexin B1, but ...
I V Nekrasova
exaly   +3 more sources

Sema4D as an inhibitory regulator in oligodendrocyte development

Molecular and Cellular Neuroscience, 2012
The specific functions of intrinsic regulators of OL differentiation are poorly understood. Sema4D, originally found as a negative regulator of axon guidance, is mainly expressed by oligodendrocytes in the postnatal brain, and our previous study revealed that the lack of Sema4D induced an increase in the number of oligodendrocytes in the cerebral ...
Wataru, Yamaguchi, Rie, Tamai, Miho, Kageura, Tatsuo, Furuyama, Shinobu, Inagaki   +4 more
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Structure and Function of the Immune Semaphorin CD100/SEMA4D

Critical Reviews in Immunology, 2003
Semaphorins are a large family of membrane-bound and secreted molecules involved in numerous functions, including axon guidance, morphogenesis, carcinogenesis, and immunomodulation. A growing number of semaphorins--namely, human CD100/SEMA4D, CD108/SEMA7A, and SEMA3A; viral semaphorins, SemaVA and SemaVB; and, very recently, mouse Sema4A--were reported
Abdellah, Elhabazi, Anne, Marie-Cardine, Isabelle, Chabbert-de Ponnat, Armand, Bensussan, Laurence, Boumsell   +4 more
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Identification of a Region within the Cytoplasmic Domain of Sema4D That Binds Calmodulin and Regulates Shedding of the Sema4D Exodomain in Platelets,

Blood, 2011
Abstract Abstract 3249 We have previously shown that the 150 kDa semaphorin family member, Sema4D (or CD100), is expressed on the surface of human and mouse platelets, where it is able to selectively reinforce collagen-initiated platelet activation by engaging receptors in trans on adjoining platelets in a contact ...
Peipei Mou, Zhao Zeng, Lijie Ren, Qiang Li, Kenneth M Wannemacher, Xi Mo, Lawrence F. Brass, Li Zhu   +7 more
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Soluble SEMA4D/CD100: A novel immunoregulator in infectious and inflammatory diseases

Clinical Immunology, 2016
SEMA4D/CD100 is a homodimeric protein belonging to the semaphorin family of axonal guidance proteins. Semaphorin family members have received increased attention lately due to their diverse functions in the immune system. SEMA4D was the first semaphorin described to have immune functions and serves important roles in T cell priming, antibody production,
Kimia T. Maleki, Martin Cornillet, Niklas K. Björkström   +2 more
openaire   +4 more sources

Deletion of the Semaphorin, Sema4D, but Not Inhibition of Sema4D Shedding by ADAM17, Impairs Platelet Function and Reduces Infarct Size After Myocardial Ischemia.

Blood, 2009
Abstract Abstract 771 Introduction. Platelets are activated early during the reperfusion of ischemic myocardium, potentially exacerbating the extent of ischemia/reperfusion (I/R) injury. We have recently shown (Zhu, et al., PNAS 2007) that platelets express the semaphorin family member, sema4D, as do T-cells.
Li Zhu, Tao Wang, Hong Jiang, Timothy J. Stalker, Karen P. Fong, Peter J. Gruber, Lawrence F Brass   +6 more
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Sema4D/PlexinB1 promotes endothelial differentiation of dental pulp stem cells via activation of AKT and ERK1/2 signaling

Journal of Cellular Biochemistry, 2019
Inducing of dental pulp stem cells (DPSCs) into endothelial cells (ECs) to prevascularize pulp tissue constructs may offer a novel and viable approach for enhancing pulp regeneration.
Ting Zou, Waruna Lakmal Dissanayaka, Boon Chin Heng   +2 more
exaly   +2 more sources

Sema4D stimulates axonal outgrowth of embryonic DRG sensory neurones

Genes to Cells, 2004
Several semaphorins are thought to function as potent inhibitors of axonal growth. We have found that Sema4D stimulates axonal outgrowth of embryonic dorsal root ganglion (DRG) neurones in stead of retraction. Neutralizing antibodies to Sema4D inhibit this action.
Kenta, Masuda, Tatsuo, Furuyama, Mizue, Takahara, Shiho, Fujioka, Hitomi, Kurinami, Shinobu, Inagaki   +5 more
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Sema4d is required for the development of the hindbrain boundary and skeletal muscle in zebrafish

Biochemical and Biophysical Research Communications, 2013
Semaphorin4d (SEMA4D), also known as CD100, an oligodendrocyte secreted R-Ras GTPase-activating protein (GAP), affecting axonal growth is involved in a range of processes including cell adhesion, motility, angiogenesis, immune responses and tumour progression. However, its actual physiological mechanisms and its role in development remain unclear. This
Jie, Yang, Zhen, Zeng, Juncheng, Wei, Lijun, Jiang, Quanfu, Ma, Mingfu, Wu, Xiaoyuan, Huang, Shuangmei, Ye, Ye, Li, Ding, Ma, Qinglei, Gao   +10 more
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Sema7A and Sema4D Heterodimerization is Essential for Membrane Targeting and Neocortical Wiring

2023
SUMMARY Disruption of neocortical circuitry and architecture in humans causes numerous neurodevelopmental disorders. Neocortical cytoarchitecture is orchestrated by various transcription factors such as Satb2 that control target genes during strict time windows.
Paraskevi Bessa, Andrew G. Newman, Kuo Yan, Theres Schaub, Rike Dannenberg, Denis Lajkó, Julia Eilenberger, Theresa Brunet, Kathrin Textoris-Taube, Emanuel Kemmler, Priyanka Banerjee, Ethiraj Ravindran, Michael Mülleder, Robert Preissner, Rudolf Grosschedl, Marta Rosário, Victor Tarabykin   +16 more
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