Results 151 to 160 of about 2,098 (175)
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A new SEMA7A variant found in Native Americans with alloantibody
Vox Sanguinis, 2010Background and Objectives John Milton Hagen (JMH) antigens are carried by Semaphorin 7A that plays important roles in the nervous system and the immune responses. Its role on the erythrocytes is unclear. Over the years, few samples were referred to our Immunohaematology Reference Laboratory to elucidate their JMH status.Materials and Methods Seven ...
M, Richard +4 more
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The molecular diversity of Sema7A, the semaphorin that carries the JMH blood group antigens
Transfusion, 2006BACKGROUND: Semaphorin 7A (Sema7A), the protein that carries the JMH blood group antigen, is involved in immune responses and plays an important role in axon growth and guidance. Because previous serologic studies on red blood cells (RBCs) suggested a considerable diversity of Sema7A, the present study was designed to elucidate the complex picture of ...
Axel, Seltsam +11 more
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Transfusion, 2008
BACKGROUND: At present, identification of antibodies against the high‐prevalence JMH antigen is difficult and limited to reference laboratories having panels of rare red blood cell (RBC) specimens in stock. Here, a novel method is described for detection of anti‐JMH with particles coated with recombinant semaphorin 7A (Sema7A, CD108), the protein that ...
Axel, Seltsam +5 more
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BACKGROUND: At present, identification of antibodies against the high‐prevalence JMH antigen is difficult and limited to reference laboratories having panels of rare red blood cell (RBC) specimens in stock. Here, a novel method is described for detection of anti‐JMH with particles coated with recombinant semaphorin 7A (Sema7A, CD108), the protein that ...
Axel, Seltsam +5 more
openaire +2 more sources
Abstract 3899: CHST11 mediated SEMA7A expression contributes to TKI resistant in lung cancer
Cancer Research, 2023Abstract An extracellular matrix has been demonstrated to be one of the substances that promote tumor cells to become driven by external stimuli to change their biology or malignancy. The main component of extracellular matrix, chondroitin sulfate, has been confirmed as a factor in the progression of tumors.
Chien-Hsiu Chris Li +3 more
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Arteriosclerosis, Thrombosis, and Vascular Biology, 2015
Background: Atherosclerosis preferentially develops in areas of arteries with arches and branches, where the flow is disturbed (D-flow). D-flow upregulates proatherogenic genes and promotes the dysfunctional endothelial cell phenotype.
Fei Yang +3 more
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Background: Atherosclerosis preferentially develops in areas of arteries with arches and branches, where the flow is disturbed (D-flow). D-flow upregulates proatherogenic genes and promotes the dysfunctional endothelial cell phenotype.
Fei Yang +3 more
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Abstract 1076: Hormonal regulation of SEMA7A promotes therapeutic resistance in ER+ breast cancer
Cancer Research, 2021Abstract Background: The majority of all breast cancers (BC) are estrogen receptor positive (ER+). While ER-targeting endocrine therapies have improved patient survival, many tumors become drug resistant and recur within 20 years. Thus, novel targets are needed to treat recurrent ER+BC.
Lyndsey S. Crump +5 more
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Microbial Pathogenesis
Abnormal activation of macrophage and gut Bacteroides fragilis (BF) are the important induction factors in the occurrence of type 2 diabetes (T2D) and vascular complications. However, it remains unknown whether BF involves in macrophage polarization. In this study, we found that BF extracellular vesicles (EV) can be uptaken by macrophage. BF-EV promote
Cong Chen +4 more
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Abnormal activation of macrophage and gut Bacteroides fragilis (BF) are the important induction factors in the occurrence of type 2 diabetes (T2D) and vascular complications. However, it remains unknown whether BF involves in macrophage polarization. In this study, we found that BF extracellular vesicles (EV) can be uptaken by macrophage. BF-EV promote
Cong Chen +4 more
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Abstract P4-02-11: A SIM2s/SEMA7A switch drives therapeutic resistance in ER+ breast cancer
Cancer Research, 2022Abstract BACKGROUND: Estrogen Receptor (ER) + breast cancers (BC) comprise over 70% of BC cases and can be targeted via ER modulated therapies. Despite this, ER+BC patients can experience recurrence within 20 years and the majority of BC related deaths can be attributed to metastatic ER+BC.
Garhett L Wyatt +3 more
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LncRNA LOXL1‐AS1/miR‐28‐5p/SEMA7A axis facilitates pancreatic cancer progression
Cell Biochemistry and Function, 2019Pancreatic cancer (PC), one of the most aggressive and lethal human malignancies, is associated with a deplorable prognosis despite progressive therapeutic strategies. Emerging evidence manifests that miR‐28‐5p is involved in several cancers, and its descending expression is associated with poor prognosis.
Yongcun Liu +3 more
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PHARMACEUTICAL COMPOSITIONS CONTAINING SEMA7A POLYPEPTIDES
2001The use of Sema7 A polypeptides and polynucleotides in the design of protocols for the treatment of autoimmune disorders, chronic obstructive pulmonary disease, inflammation, psoriasis, wound healing, tissue repair, irritable bowel syndrome, stroke, atherosclerosis, cancer among others, and diagnostic assays for such conditions.
SMITHKLINE BEECHAM PLC +2 more
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