Results 91 to 100 of about 910 (176)

A functional coupling between CRMP1 and Nav1.7 for retrograde propagation of Semaphorin3A signaling

, 2017
Semaphorin3A (Sema3A) is a secreted type of axon guidance molecules that regulates axon wiring through neuropilin-1 (NRP1) and PlexinAs (PlexAs) receptor complex.
Masayuki Yamane, Yoshinori Kamiya, Naoya Yamashita, Fumio Nakamura, Yoshio Goshima, Tomonobu Hida, Pappachan Kolattukudy   +6 more
core   +2 more sources

Decreased Expression of Semaphorin3A/Neuropilin-1 Signaling Axis in Apical Periodontitis [PDF]

, 2017
Apical periodontitis (AP) is a chronic infection of endodontic origin accompanied with bone destruction around the apical region. Semaphorin3A (Sema3A) and neuropilin-1 (Nrp1) are regarded as a pair of immune regulators in bone metabolism. In this study,
Mary Anne Sampaio de Melo, Hockin H. K. Xu, Quan Xing, Xiaolei Zhang, Meng Xu, Rui Zou, Ying Lin, Zhengmei Lin, Wei Qin   +8 more
core   +1 more source

Fragile X mental retardation protein is involved in protein synthesis-dependent collapse of growth cones induced by Semaphorin-3A

Frontiers in Neural Circuits, 2009
Fragile X syndrome, the most frequent form of familial mental retardation, is caused by mutation of the Fmr1 gene. Fmr1 encodes the Fragile X Mental Retardation Protein (FMRP), an mRNA binding protein regulating local, postsynaptic mRNA translation ...
Chanxia Li, Gary j Bassell, Gary j Bassell, Yukio Sasaki   +3 more
doaj   +1 more source

The mechanical regulation of Semaphorin3A signalling in the developing Xenopus laevis brain

Establishing neuronal connectivity accurately during development is vital for the functioning of the mature brain. Failure of axons to connect to their correct downstream targets is linked to a host of neurodevelopmental disorders.

core   +1 more source

Overexpression of Semaphorin-3A and Semaphorin-4D in the Peripheral Blood from Newly Diagnosed Patients with Chronic Lymphocytic Leukemia

International Journal of Hematology-Oncology and Stem Cell Research, 2019
Background: Semaphorins play prominent roles in physiological and pathological processes such as vascular development, tumor growth and immune responses. Semaphorins have different roles in various kinds of cancers, but there is no study concerning their
Somayeh Parsa, Sedigheh Sharifzadeh, Ahmad Monabati, Noorossadat Seyyedi, Reza Ranjbaran, Mohammad Reza Baghbani, Maryam Nemati, Abdollah Jafarzadeh   +7 more
doaj   +1 more source

Nestin in immature embryonic neurons affects axon growth cone morphology and Semaphorin3a sensitivity

, 2019
Correct wiring in the neocortex requires that responses to an individual guidance cue vary among neurons in the same location, and within the same neuron over time.
Winckler, B., Bott, C. J., Litwa, K. A., Yap, C. C., Dwyer, N. D., Johnson, C. G.   +5 more
core   +2 more sources

Sema3a Promotes Type H Vessel Formation Via Nrp1pdgf-Bb

International Dental Journal
Aim or purpose: To investigate the effect of Semaphorin3A (Sema3A) on type H vessel formation and alveolar bone resorption within periodontitis. Materials and methods: Conditioned media derived from preosteoclasts pretreated with the Sema3A, Sema3A ...
Maerwa Mulatihaji, Yi-Fan Zhang, Huan Zhou   +2 more
doaj   +1 more source

Slit and Netrin-1 guide cranial motor axon pathfinding via Rho-kinase, myosin light chain kinase and myosin II

Neural Development, 2010
Background In the developing hindbrain, cranial motor axon guidance depends on diffusible repellent factors produced by the floor plate. Our previous studies have suggested that candidate molecules for mediating this effect are Slits, Netrin-1 and ...
Drescher Uwe, Barnes Sarah H, Naeem Arifa, Murray Ailish, Guthrie Sarah   +4 more
doaj   +1 more source

Semaphorin3A Alleviates Skin Lesions and Scratching Behavior in NC/Nga Mice, an Atopic Dermatitis Model

, 2008
Topical steroids and antihistamines are commonly used for the treatment of atopic dermatitis (AD). However, in a substantial number of patients with AD, these treatments are not sufficiently effective.
Nakamura, Fumio, Takei, Kohtaro, Zenro Ikezawa, Ikezawa, Zenro, Naoya Yamashita, Nagashima, Yoji, Yamaguchi, Junko, Fumio Nakamura, Yoshio Goshima, Michiko Aihara, Aihara, Michiko, Usui, Hiroshi, Yamashita, Naoya, Hiroshi Usui, Kohtaro Takei, Junko Yamaguchi, Tomonobu Hida, Goshima, Yoshio, Hida, Tomonobu, Yoji Nagashima   +19 more
core   +1 more source

Analysis of gene expression during neurite outgrowth and regeneration

BMC Neuroscience, 2007
Background The ability of a neuron to regenerate functional connections after injury is influenced by both its intrinsic state and also by extrinsic cues in its surroundings.
Tai Yu, Vranizan Karen, Szpara Moriah L, Goodman Corey S, Speed Terence P, Ngai John   +5 more
doaj   +1 more source