Results 71 to 80 of about 910 (176)

Pure platelet-rich plasma promotes semaphorin-3A expression: a novel insight to ameliorate intervertebral disk degeneration in vitro

open access: yesJournal of Orthopaedic Surgery and Research, 2023
Introduction Intervertebral disk degeneration (IVDD) can be effectively treated using platelet-rich plasma (PRP). While the exact process is fully understood, it is believed that using pure PRP (P-PRP) without leukocytes is a better option for preventing
Jie Huang   +4 more
doaj   +1 more source

PS5:108 Semaphorin3a: a beneficial therapy for lupus nephritis [PDF]

open access: yesPoster session 5: Innate and adaptive immunity, 2018
Background The immune regulatory properties of semaphorin3A (sema3A) (both innate and adaptive) are well established in many in-vitro studies. When sema3A was incubated with active B cells from SLE patients, it could efficiently reduce the expression of TLR-9 in correlation with a significant reduction of relevant auto-antibodies.
E Toubi, Z Vadasz
openaire   +1 more source

Semaphorin-3A, semaphorin-7A gene single nucleotide polymorphisms, and systemic lupus erythematosus susceptibility

open access: yesAutoimmunity, 2019
Background: Semaphorin-3A (Sema3A) and Semaphorin-7A (Sema7A) play crucial roles in immune system by inhibiting T cell proliferation and leading to the secretion of pro-inflammatory cytokines.
Li-Na Liu   +7 more
doaj   +1 more source

Semaphorin 3A is a new early diagnostic biomarker of experimental and pediatric acute kidney injury. [PDF]

open access: yesPLoS ONE, 2013
Semaphorin 3A is a secreted protein that regulates cell motility and attachment in axon guidance, vascular growth, immune cell regulation and tumor progression. However, nothing is known about its role in kidney pathophysiology.
Calpurnia Jayakumar   +5 more
doaj   +1 more source

Developments of Thermosensitive Hydrogel for Maxillofacial Bone Regeneration

open access: yesSmall Science, Volume 5, Issue 10, October 2025.
Thermosensitive hydrogel with seed cells and growth factors presents a new method for bone regeneration, changing states with temperature and offering fluidity, injectability, and controlled drug release. This article reviews thermosensitive hydrogel's role in angiogenesis, neurogenesis, and osteogenesis in maxillofacial bone regeneration and discusses
Qinrou Zhang   +11 more
wiley   +1 more source

A Subtle Network Mediating Axon Guidance: Intrinsic Dynamic Structure of Growth Cone, Attractive and Repulsive Molecular Cues, and the Intermediate Role of Signaling Pathways

open access: yesNeural Plasticity, Volume 2019, Issue 1, 2019., 2019
A fundamental feature of both early nervous system development and axon regeneration is the guidance of axonal projections to their targets in order to assemble neural circuits that control behavior. In the navigation process where the nerves grow toward their targets, the growth cones, which locate at the tips of axons, sense the environment ...
Xiyue Ye   +5 more
wiley   +1 more source

Inhibition of neuronal apoptosis and axonal regression ameliorates sympathetic atrophy and hemodynamic alterations in portal hypertensive rats. [PDF]

open access: yesPLoS ONE, 2014
BACKGROUND AND AIM:A neuronal pathway participates in the development of portal hypertension: blockade of afferent sensory nerves in portal vein ligated (PVL) rats simultaneously prevents brain cardiovascular regularory nuclei activation, neuromodulator ...
Nahia Ezkurdia   +6 more
doaj   +1 more source

Elp1 function in placode‐derived neurons is critical for proper trigeminal ganglion development

open access: yesDevelopmental Dynamics, Volume 254, Issue 6, Page 494-512, June 2025.
Abstract Background The trigeminal nerve is the largest cranial nerve and functions in somatosensation. Cell bodies of this nerve are positioned in the trigeminal ganglion, which arises from the coalescence of neural crest and placode cells. While this dual cellular origin has been known for decades, the molecular mechanisms controlling trigeminal ...
Margaret A. Hines, Lisa A. Taneyhill
wiley   +1 more source

Neurovascular congruence results from a shared patterning mechanism that utilizes Semaphorin3A and Neuropilin-1

open access: yes, 2003
Peripheral nerves and blood vessels have similar patterns in quail forelimb development. Usually, nerves extend adjacent to existing blood vessels, but in a few cases, vessels follow nerves.
Nadine Watson   +26 more
core   +1 more source

Semaphorin-3A Promotes Degradation of Fragile X Mental Retardation Protein in Growth Cones via the Ubiquitin-Proteasome Pathway

open access: yesFrontiers in Neural Circuits, 2020
Fragile X mental retardation protein (FMRP) is an RNA-binding protein that regulates local translation in dendrites and spines for synaptic plasticity. In axons, FMRP is implicated in axonal extension and axon guidance.
Masaru Takabatake   +2 more
doaj   +1 more source

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