Results 61 to 70 of about 910 (176)

Expression of Semaphorin 3A in Malignant and Normal Bladder Tissue: Immunohistochemistry Staining and Morphometric Evaluation

Biology, 2021
Introduction: Our previous studies showed elevated levels of Semaphorin3a (Sema3A) in the urine of patients with urothelial cancer compared to healthy patients.
Ilan Bejar, Jacob Rubinstein, Jacob Bejar, Edmond Sabo, Hilla K Sheffer, Zaher Bahouth, Sarel Halachmi, Zahava Vadasz   +7 more
doaj   +1 more source

Decreased Semaphorin3A expression correlates with disease activity and histological features of rheumatoid arthritis

BMC Musculoskeletal Disorders, 2013
Background Rheumatoid arthritis (RA) is an autoimmune disease of which the pathogenetic mechanisms are not fully understood. Semaphorin3A (Sema3A) has an immune regulatory role.
Takagawa Shu, Nakamura Fumio, Kumagai Ken, Nagashima Yoji, Goshima Yoshio, Saito Tomoyuki   +5 more
doaj   +1 more source

Cdc42 and RhoA reveal different spatio-temporal dynamics upon local stimulation with Semaphorin-3A

Frontiers in Cellular Neuroscience, 2015
Small RhoGTPases, such as Cdc42 and RhoA, are key players in integrating external cues and intracellular signaling pathways that regulate growth cone (GC) motility.
Federico eIseppon, Luisa Maria Rosaria Napolitano, Luisa Maria Rosaria Napolitano, Vincent eTorre, Dan eCojoc   +4 more
doaj   +1 more source

Rewiring of regenerated axons by combining treadmill training with semaphorin3A inhibition [PDF]

Molecular Brain, 2014
Rats exhibit extremely limited motor function recovery after total transection of the spinal cord (SCT). We previously reported that SM-216289, a semaphorin3A inhibitor, enhanced axon regeneration and motor function recovery in SCT adult rats. However, these effects were limited because most regenerated axons likely do not connect to the right targets.
Zhang, Liang, Kaneko, Shinjiro, Kikuchi, Kaoru, Sano, Akihiko, Maeda, Miho, Kishino, Akiyoshi, Shibata, Shinsuke, Mukaino, Masahiko, Toyama, Yoshiaki, Liu, Meigen, Kimura, Toru, Okano, Hideyuki, Nakamura, Masaya   +12 more
openaire   +2 more sources

Regulation of Dendritic Branching and Spine Maturation by Semaphorin3A-Fyn Signaling [PDF]

The Journal of Neuroscience, 2006
A member of semaphorin family, semaphorin3A (Sema3A), acts as a chemorepellent or chemoattractant on a wide variety of axons and dendrites in the development of the nervous systems. We here show that Sema3A induces clustering of both postsynaptic density-95 (PSD-95) and presynaptic synapsin I in cultured cortical neurons without changing the density of
Asa, Morita, Naoya, Yamashita, Yukio, Sasaki, Yutaka, Uchida, Oumi, Nakajima, Fumio, Nakamura, Takeshi, Yagi, Masahiko, Taniguchi, Hiroshi, Usui, Ritsuko, Katoh-Semba, Kohtaro, Takei, Yoshio, Goshima   +11 more
openaire   +2 more sources

Altered morphologies and functions of the olfactory bulb and hippocampus induced by miR-30c

Frontiers in Neuroscience, 2016
Adult neurogenesis is considered to contribute to a certain degree of plasticity for the brain. However, the effects of adult-born neurons on the brain are still largely unknown.
Tingting eSun, Tianpeng eLi, Henry eDavies, Weiyun eLi, Jing eYang, Shanshan eLi, Shucai eLing   +6 more
doaj   +1 more source

Human Muscle Progenitor Cells Displayed Immunosuppressive Effect through Galectin-1 and Semaphorin-3A

Stem Cells International, 2012
In human skeletal muscle, myoblasts represent the main population of myogenic progenitors. We previously showed that, beside their myogenic differentiation capacities, myoblasts also differentiate towards osteogenic and chondrogenic lineages, some ...
Séverine Lecourt, Yves Lepelletier, Valérie Vanneaux, Rafika Jarray, Thomas Domet, Françoise Raynaud, Réda Hadj-Slimane, Audrey Cras, Olivier Hermine, Jean-Pierre Marolleau, Jérôme Larghero   +10 more
doaj   +1 more source

Compromised angiogenesis and vascular Integrity in impaired diabetic wound healing.

PLoS ONE, 2020
Vascular deficits are a fundamental contributing factor of diabetes-associated diseases. Although previous studies have demonstrated that the pro-angiogenic phase of wound healing is blunted in diabetes, a comprehensive understanding of the mechanisms ...
Uzoagu A Okonkwo, Lin Chen, Da Ma, Veronica A Haywood, May Barakat, Norifumi Urao, Luisa A DiPietro   +6 more
doaj   +1 more source

Peripheral nerve injury fails to induce growth of lesioned ascending dorsal column axons into spinal cord scar tissue expressing the axon repellent Semaphorin3A

, 2001
We have investigated the hypothesis that the chemorepellent Semaphorin3A may be involved in the failure of axonal regeneration after injury to the ascending dorsal columns of adult rats.
Patrick N. Anderson, R. Jeroen Pasterkamp, Pasterkamp, R.J., Pasterkamp, R Jeroen, Verhaagen, J., Anderson, Patrick N, Verhaagen, J, Anderson, P.N., Joost Verhaagen   +8 more
core   +1 more source

Retrograde signaling via axonal transport through signaling endosomes

Journal of Pharmacological Sciences, 2019
Neurons extend axons far from cell bodies, and retrograde communications from distal axons to cell bodies and/or dendrites play critical roles in the development and maintenance of neuronal circuits.
Naoya Yamashita
doaj   +1 more source