Results 41 to 50 of about 910 (176)
Biomolecules, 2020 The chondroitin sulfate (CS)-rich dense extracellular matrix surrounding neuron cell bodies and proximal dendrites in a mesh-like structure is called a perineuronal net (PNN).
Satomi Nadanaka +5 more
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RhoA is dispensable for axon guidance of sensory neurons in the mouse dorsal root ganglia
Frontiers in Molecular Neuroscience, 2012 RhoA, a member of Rho family small GTPases, has been shown to play important roles in axon guidance. However, it remains unknown whether RhoA is actually required for any axon guidance events in vivo in the mammalian nervous system.
Jennifer R Leslie +5 more
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Semaphorin3a signaling, podocyte shape, and glomerular disease [PDF]
Pediatric Nephrology, 2014 Semaphorin3a (sema3a), a member of class 3 semaphorins, is a guidance protein that regulates angiogenesis, branching morphogenesis, axon growth, and cell migration, and has pleiotropic roles on organogenesis, immune response, and cancer. Sema3a is secreted by podocytes and is required for normal kidney patterning and glomerular filtration barrier ...
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Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons. [PDF]
PLoS ONE, 2013 Statoacoustic ganglion (SAG) neurons project sensory afferents to appropriate targets in the inner ear to form functional vestibular and auditory circuits.
Kei-ichi Katayama +3 more
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Involvement of Semaphorin3A in Nasopharyngeal Carcinoma and its Therapeutic Application
, 2022 The purpose of this study is to investigate the association between Epstein Barr Virus (EBV)-associated nasopharyngeal carcinoma and Semaphorin3A (Sema3A) and to establish basic data for the development of new immune checkpoint inhibitors targeting ...
加瀬, 希奈, 20835649, 84387
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Semaphorin-3A as An Immune Modulator Is Suppressed by MicroRNA-145-5p
Cell Journal, 2018 Objective Semaphorin-3A (SEMA3A) and its receptors are found on some immune cells and act as suppressors of immune cells over-activation. Considering the role of SEMA3A and its down-regulation in some autoimmune diseases, as well as our bioinformatics ...
Mahsa Rezaeepoor +6 more
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RanBPM Contributes to Semaphorin3A Signaling through Plexin-A Receptors [PDF]
The Journal of Neuroscience, 2006 Secreted Semaphorin3A (Sema3A) proteins are known to act as diffusible and repellant axonal guidance cues during nervous system development. A receptor complex consisting of a Neuropilin and a Plexin-A mediates their effects. Plexin-A signal transduction has remained poorly defined despite the documented involvement of collapsin response mediator ...
Hideaki, Togashi +2 more
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A PKC-dependent recruitment of MMP-2 controls semaphorin-3A growth-promoting effect in cortical dendrites. [PDF]
PLoS ONE, 2009 There is increasing evidence for a crucial role of proteases and metalloproteinases during axon growth and guidance. In this context, we recently described a functional link between the chemoattractive Sema3C and Matrix metalloproteinase 3 (MMP3).
Bertrand Gonthier +7 more
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Indian Journal of Rheumatology, 2022 Background: Semaphorin-3A (Sema-3A) is an important immunoregulator protein; it has a role in the maintenance of self-tolerance, so it is thought to be involved in the pathogenesis of many autoimmune diseases such as systemic lupus erythematosus (SLE ...
Alaa Saber Shams +3 more
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Semaphorin3a inhibits ureteric bud branching morphogenesis
Mechanisms of Development, 2008 Class 3 semaphorins are guidance proteins involved in axon pathfinding, vascular patterning and lung branching morphogenesis in the developing mouse embryo. Semaphorin3a (Sema3a) is expressed in renal epithelia throughout kidney development, including podocytes and ureteric bud cells.
Tufro, Alda +3 more
openaire +2 more sources