Results 21 to 30 of about 910 (176)
Semaphorin3A, Neuropilin-1, and PlexinA1 Are Required for Lymphatic Valve Formation [PDF]
Circulation Research, 2012 Rationale: The lymphatic vasculature plays a major role in fluid homeostasis, absorption of dietary lipids, and immune surveillance. Fluid transport depends on the presence of intraluminal valves within lymphatic collectors.
Bouvree, Karine +15 more
openaire +6 more sources
Semaphorin3A induces nerve regeneration in the adult cornea-a switch from its repulsive role in development. [PDF]
PLoS ONE, 2018 The peripheral sensory nerves that innervate the cornea can be easily damaged by trauma, surgery, infection or diabetes. Several growth factors and axon guidance molecules, such as Semaphorin3A (Sema3A) are upregulated upon cornea injury.
Min Zhang +5 more
doaj +2 more sources
Virchows Archiv, 2009 The immunoexpression of the antiangiogenic factor semaphorin3A (SEMA3A) was evaluated in a series of meningiomas. Then, its correlations with the microvessel density (MVD) of the tumors and with the clinicopathological parameters as well with the survival time or recurrence-free interval were investigated.
BARRESI, Valeria +2 more
openaire +3 more sources
The Guidance Molecule Semaphorin3A is Differentially Involved in the Arealization of the Mouse and Primate Neocortex [PDF]
Cerebral Cortex, 2013 The visual cortex is organized into discrete domains characterized by their specific function, connectivity, chemoarchitecture, and cytoarchitecture. Gradients of transcription factors across the anteroposterior and mediolateral axes of the neocortex have previously been demonstrated to specify the main sensory regions. However, they do not account for
Jihane, Homman-Ludiye, James A, Bourne
openaire +4 more sources
Low Urine Secretion of Semaphorin3A In Lupus Patients With Proteinuria [PDF]
Inflammation, 2021 Abstract Background: Immune semaphorins are important players in controlling both innate and adaptive immune responses. The regulatory role of semaphorin3A (sema3A) in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other autoimmune diseases is widely reported.
Doron Rimar +8 more
openaire +2 more sources
Regulation of Semaphorin3A in the process of cutaneous wound healing
Cell Death & Differentiation, 2022 AbstractSemaphorin 3A (Sema3A) has been recognized as a crucial regulator of morphogenesis and homeostasis over a wide range of organ systems. However, its function in cutaneous wound healing is poorly understood. In our study, we demonstrated that Sema3A adenovirus plasmids transfection limited keratinocyte proliferation and decreased migrative ...
Yang Zheng +16 more
openaire +2 more sources
The role of tumor‐associated macrophages in hepatocellular carcinoma progression: A narrative review
Cancer Medicine, Volume 12, Issue 24, Page 22109-22129, December 2023., 2023 Abstract Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world, with complex etiology and mechanism, and a high mortality rate. Tumor‐associated macrophages (TAMs) are an important part of the HCC tumor microenvironment.
Xinyi Zhang +6 more
wiley +1 more source
Injectable decellularized nucleus pulposus tissue exhibits neuroinhibitory properties
JOR SPINE, Volume 5, Issue 1, March 2022., 2022 A whole porcine nucleus pulposus decellularization method was optimized. The decellularized tissue was used to create a thermally forming gel that maintained nucleus pulposus cell viability and inhibited dorsal root ganglion neurite growth. Abstract Background Chronic low back pain (LBP) is a leading cause of disability, but treatments for LBP are ...
Logan M. Piening +5 more
wiley +1 more source
Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain
Cells, 2020 Konjac ceramide (kCer) is a plant-type ceramide composed of various long-chain bases and α-hydroxyl fatty acids. The presence of d4t,8t-sphingadienine is essential for semaphorin 3A (Sema3A)-like activity. Herein, we examined the three neuropilin 1 (
Seigo Usuki +11 more
doaj +1 more source
Negative Regulation of Semaphorin-3A Expression in Peripheral Blood Mononuclear Cells Using MicroRNA-497-5p [PDF]
Iranian Journal of Medical Sciences, 2019 Background: Semaphorin-3A (Sema3A), as a secreted semaphorin, is an immune modulator molecule participating in the pathogenesis of autoimmune diseases. MicroRNAs (miRNAs) modulate the target-gene expression at the post-transcriptional level.
Shima Shapoori +6 more
doaj +1 more source