Semaphorin3A-Inhibitor Ameliorates Doxorubicin-Induced Podocyte Injury [PDF]
International Journal of Molecular Sciences, 2020 Podocyte injury is an independent risk factor for the progression of renal diseases. Semaphorin3A (SEMA3A), expressed in podocytes and tubular cells in the mammalian adult kidneys, has been reported to regulate diverse biological functions and be associated with renal diseases.
Kenji Tsuji +2 more
exaly +9 more sources
Semaphorin3A/PlexinA3 association with the Scribble scaffold for cGMP increase is required for apical dendrite development [PDF]
Cell Reports, 2022 International audienceThe development of the apical dendrite from the leading process of the bipolar pyramidal neuron might be directed by spatially organized extrinsic cues acting on localized intrinsic determinants.
Edward Martinez +2 more
exaly +3 more sources
Semaphorin3a Promotes Advanced Diabetic Nephropathy [PDF]
Diabetes, 2014 The onset of diabetic nephropathy (DN) is highlighted by glomerular filtration barrier abnormalities. Identifying pathogenic factors and targetable pathways driving DN is crucial to developing novel therapies and improving the disease outcome. Semaphorin3a (sema3a) is a guidance protein secreted by podocytes.
Aggarwal, Pardeep K +6 more
openaire +6 more sources
Lens-derived Semaphorin3A regulates sensory innervation of the cornea [PDF]
Developmental Biology, 2007 The cornea, one of the most highly innervated tissues of the body, is innervated by trigeminal sensory afferents. During development, axons are initially repelled at the corneal margin, resulting in the formation of a circumferential nerve ring. The nature and source of guidance molecules that regulate this process remain a mystery.
Lwigale, Peter Y. +1 more
openaire +4 more sources
Meningiomas: Role of Semaphorin3A Protein in Antiangiogenesis
, 2012 Meningiomas represent frequent tumors mainly characterized by a benign histology and an indolent clinical course. The histological grade and extent of surgical resection are considered to be the most powerful prognosticators for these neoplasias.
Valeria Barresi, Barresi V
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Vinaxanthone inhibits Semaphorin3A induced axonal growth cone collapse in embryonic neurons but fails to block its growth promoting effects on adult neurons [PDF]
Scientific Reports, 2021 Semaphorin3A is considered a classical repellent molecule for developing neurons and a potent inhibitor of regeneration after nervous system trauma. Vinaxanthone and other Sema3A inhibitors are currently being tested as possible therapeutics to promote ...
Evguenia Ivakhnitskaia +3 more
doaj +2 more sources
TAG1 Regulates the Endocytic Trafficking and Signaling of the Semaphorin3A Receptor Complex [PDF]
The Journal of Neuroscience, 2012 Endocytic trafficking of membrane proteins is essential for neuronal structure and function. We show that Transient Axonal Glycoprotein 1 (TAG1 or CNTN2), a contactin-related adhesion molecule, plays a central role in the differential trafficking of components of the semaphorin3A (Sema3A) receptor complex into distinct endosomal compartments in murine ...
Dang, P., Smythe, E., Furley, A. J.
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Extracellular vesicle-transported Semaphorin3A promotes vascular permeability in glioblastoma [PDF]
Oncogene, 2015 Glioblastoma are malignant highly vascularized brain tumours, which feature large oedema resulting from tumour-promoted vascular leakage. The pro-permeability factor Semaphorin3A (Sema3A) produced within glioblastoma has been linked to the loss of endothelial barrier integrity.
Treps, L +9 more
openaire +5 more sources
Semaphorin3A regulates synaptic function of differentiated hippocampal neurons
European Journal of Neuroscience, 2006 AbstractSemaphorins are major chemorepellents for developing neuronal projections. Their persistent expression at adult stages suggests that they may contribute to the functioning of neuronal circuits. We investigated the functional properties of semaphorin3A (Sema3A) in adult hippocampal neurons, and report that exogenous application of this cue ...
Bouzioukh, Farima +5 more
openaire +5 more sources
Adriamycin-induced podocyte injury via the Sema3A/TRPC5/Rac1 pathway [PDF]
Frontiers in MedicinePodocytopathies encompass kidney diseases where direct or indirect podocyte injury leads to proteinuria or nephrotic syndrome. Although Semaphorin3A (Sema3A) is expressed in podocytes and tubular cells in adult mammalian kidneys and has a common effect ...
Yan Liu +8 more
doaj +2 more sources