Semaphorin3A Exacerbates Cardiac Microvascular Rarefaction in Pressure Overload‐Induced Heart Disease [PDF]
Advanced Science, 2023 Microvascular endothelial cells (MiVECs) impair angiogenic potential, leading to microvascular rarefaction, which is a characteristic feature of chronic pressure overload‐induced cardiac dysfunction.
Chaofu Li, Zimu Wang
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Semaphorin3A: A Potential Therapeutic Tool for Lupus Nephritis [PDF]
Frontiers in Immunology, 2018 BackgroundThe immune regulatory properties of semaphorin3A (sema3A) (both innate and adaptive) are well established in many in vitro studies. The injection of sema3A into a mice model of rheumatoid arthritis was proven to be highly beneficial, both in ...
Ofra Kessler +2 more
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EA Improves the Motor Function in Rats with Spinal Cord Injury by Inhibiting Signal Transduction of Semaphorin3A and Upregulating of the Peripheral Nerve Networks [PDF]
Neural Plasticity, 2020 Peripheral nerve networks (PNNs) play a vital role in the neural recovery after spinal cord injury (SCI). Electroacupuncture (EA), as an alternative medicine, has been widely used in SCI and was proven to be effective on neural functional recovery.
Rong Hu +7 more
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Truncated-semaphorin3A is a potential regulatory molecule to restore immune homeostasis in immune-mediated diseases [PDF]
Frontiers in Pharmacology, 2023 Regulatory molecules have recently been recognized for their beneficial effects in the treatment of immune-mediated diseases, rather than using cytotoxic immune-suppressing drugs, which are associated with many unwanted side effects. Semaphorin3A (sema3A)
Nasren Eiza +6 more
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Overexpressed Neuropilin-1 in Endothelial Cells Promotes Endothelial Permeability through Interaction with ANGPTL4 and VEGF in Kawasaki Disease. [PDF]
Mediators Inflamm, 2021 Disrupted endothelial permeability plays a crucial role in the vasculitis pathogenesis of Kawasaki disease (KD), which leads to pathological vascular leak and facilitates inflammatory cell infiltration in vascular lesions; however, the mechanisms involved in the development of endothelial barrier dysfunction during KD vasculitis are still largely ...
Huang J, Zhang S.
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Trio and CRMP2 regulate axon branching and Semaphorin3A signaling [PDF]
Communications BiologyTrio is a neuronally expressed, Rac1- and RhoA-activating RhoGEF, that is required for neurodevelopment. Mutations affecting the Rac1-activating GEF domain of Trio are associated with profound neurodevelopmental delay and Trio knock-out is embryonic ...
Erin Fingleton +5 more
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Epigallocatechin-3-gallate alleviates gestational stress-induced postpartum anxiety and depression-like behaviors in mice by downregulating semaphorin3A and promoting GSK3β phosphorylation in the hippocampus [PDF]
Frontiers in Molecular Neuroscience, 2023 IntroductionPostpartum depression (PPD) is a common neuropsychiatric disorder characterized by depression and comorbid anxiety during the postpartum period. PPD is difficult to treat because of its elusive mechanisms. Epigallocatechin-3-gallate (EGCG), a
Fang Xu +8 more
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EMBO Molecular Medicine, 2015 VEGF is widely investigated for therapeutic angiogenesis, but while short‐term delivery is desirable for safety, it is insufficient for new vessel persistence, jeopardizing efficacy.
Šime Brkic +2 more
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Semaphorin3A increases M1-like microglia and retinal ganglion cell apoptosis after optic nerve injury [PDF]
Cell & Bioscience, 2021 Background The mechanisms leading to retinal ganglion cell (RGC) death after optic nerve injury have not been fully elucidated. Current evidence indicates that microglial activation and M1- and M2-like dynamics may be an important factor in RGC apoptosis
Liu Yun-Jia +5 more
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The level of urinary semaphorin3A is associated with disease activity in patients with minimal change nephrotic syndrome [PDF]
International Journal of Nephrology and Renovascular Disease, 2017 Akiko Inoue-Torii,1 Shinji Kitamura,1 Jun Wada,1 Kenji Tsuji,2 Hirofumi Makino1 1Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; 2Center for Systems ...
Inoue-Torii A +4 more
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