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Semaphorins in health and disease
Cytokine & Growth Factor Reviews, 2021Cell-cell communication is pivotal to guide embryo development, as well as to maintain adult tissues homeostasis and control immune response. Among extracellular factors responsible for this function, are the Semaphorins, a broad family of around 20 different molecular cues conserved in evolution and widely expressed in all tissues.
Damon Fard, Luca Tamagnone
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Control of semaphorin signaling
Current Opinion in Neurobiology, 2002Receptor complexes for the chemorepellent factors of the semaphorin family activate intracellular pathways that trigger actin rearrangements underlying growth cone collapse and repellent behavior. Some evidence has been provided for a complex and dynamic pattern of interaction between members of the small Rho guanosine triphosphatases and plexin ...
Castellani, Valérie, Rougon, Geneviève
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Osteoprotection by semaphorin 3A
Nature, 2012The bony skeleton is maintained by local factors that regulate bone-forming osteoblasts and bone-resorbing osteoclasts, in addition to hormonal activity. Osteoprotegerin protects bone by inhibiting osteoclastic bone resorption, but no factor has yet been identified as a local determinant of bone mass that regulates both osteoclasts and osteoblasts ...
Mikihito, Hayashi +5 more
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Receptors for collapsin/semaphorins
Current Opinion in Neurobiology, 1998Chemorepulsive signals that repel or paralyze neuronal growth cones have been found to play important roles in axon guidance in a stereotyped manner. Recent progress in the identification of neuropilins as the receptors for class III secreted collapsin/semaphorin subfamily members, which are neuronal repellents, and in the analysis of mutant mice ...
H, Fujisawa, T, Kitsukawa
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CD100 is a leukocyte semaphorin
Cellular and Molecular Life Sciences CMLS, 1998CD100 was originally described as an activation molecule on the surface of human T lymphocytes. Its triggering through distinct epitopes leads to different signals of costimulation with phorbol myristate acetate (PMA) or with CD3 and CD2. Interestingly, CD100 was shown to associate with different partner molecules in T cells. First, CD100 can associate
S, Delaire +3 more
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Cloning and Characterization of a Novel Class VI Semaphorin, Semaphorin Y
Molecular and Cellular Neuroscience, 1999Semaphorins comprise a large family of proteins implicated in axonal guidance. We cloned a novel transmembrane semaphorin, semaphorin Y (Sema Y), which has a class VI sema domain. Sema Y shows growth cone collapsing activity on DRG neurons in vitro, and the target regions of the DRG neurons express sema Y mRNA during development.
K, Kikuchi +6 more
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GTPases in Semaphorin Signaling
2007A hallmark of semaphorin receptors is their interaction with multiple GTPases. Plexins, the signal transducing component of semaphorin receptors, directly associate with several GTPases. In addition, they not only recruit guaninine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs) but also are the only known integral membrane ...
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Trends in cell biology, 2010
To establish axonal connections growth cones must navigate multiple intermediate targets before reaching their final target. During this journey growth cones are guided by extracellular repulsive and attractive signals. Although initially identified as repulsive molecules, members of the semaphorin family include both attractants and repellents.
Derijck, Alwin A.H.A. +2 more
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To establish axonal connections growth cones must navigate multiple intermediate targets before reaching their final target. During this journey growth cones are guided by extracellular repulsive and attractive signals. Although initially identified as repulsive molecules, members of the semaphorin family include both attractants and repellents.
Derijck, Alwin A.H.A. +2 more
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[Semaphorin and osteoporosis.]
Clinical calcium, 2017Although Semaphorins were originally identified as neuronal axon guidance molecules, recent research has revealed the functions of Semaphorins in many organs, tissues and cells. Among Semaphorin family members, Semaphorin 3A(Sema3A)and Sema4D are highly expressed in bone cells and play critical roles in the regulation of bone homeostasis.
Mikihito, Hayashi, Tomoki, Nakashima
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