Ferricytochrome c Directly Oxidizes Aminoacetone to Methylglyoxal, a Catabolite Accumulated in Carbonyl Stress [PDF]
Age-related diseases are associated with increased production of reactive oxygen and carbonyl species such as methylglyoxal. Aminoacetone, a putative threonine catabolite, is reportedly known to undergo metal-catalyzed oxidation to methylglyoxal, NH4 ...
Bechara, Etelvino José Henriques +8 more
core +2 more sources
Partially Biobased Self‐Repairing Poly(Aspartic Ester Polyurea) Coatings
Sustainable self‐healing PAEU coatings, containing various amounts of disulfide derived from poly(aspartic esters) and biobased polyisocyanates, were created. ABSTRACT Poly(aspartic ester polyurea) (PAEU) coating systems, which feature an uncatalyzed and solventless reaction, have attracted attention as a more environmentally friendly, nonreactive ...
Sevilay Dural +2 more
wiley +1 more source
Kommunale Kläranlagen gelten als Haupteintragspfad organischer Mikroschadstoffe in die aquatische Umwelt. Ein Großteil der Arzneimittelrückstände und Industriechemikalien wird in Kläranlagen nicht oder nur teilweise entfernt. Um einen qualitativ höheren Kläranlagen‐Ablauf zu erzeugen, wird eine Kombination aus hybridem Teilstrom‐Membran‐Bioreaktor mit ...
Maximilian Werner +4 more
wiley +1 more source
Convulsant Effects of Semicarbazide in Epileptic Monkeys.
Summary(1) Threshold convulsant dosages to rapid intravenous injection of semicarbazide were significantly lower in chronically epileptic monkeys than in normal unoperated controls. (2) Clinical seizures following intravenous injection of threshold convulsant doses of semicarbazide occurred after a latent period of 2 to 3 1/2 hours. With suprathreshold
L M, KOPELOFF, J G, CHUSID, N, KOPELOFF
openaire +2 more sources
Identification of inhibitors of the Salmonella FraB deglycase, a drug target
A high‐throughput screen was used to identify inhibitors of Salmonella FraB, a drug target. Characterization of top hits (identified after an additional counter screen) revealed that some triazolidines, thiadiazolidines, and triazolothiadiazoles are mixed‐type inhibitors of FraB.
Jamison D. Law +6 more
wiley +1 more source
Synthesis and reducing power assay of methyl semicarbazone derivatives
In the present study we have designed a new pharmacophore ‘Chalconesemicarbazone’ by pharmacophore hybridization approach of drug design. A series of novel chalconesemicarbazones was synthesized and evaluated for their antioxidant activity by reducing ...
Manmohan Singhal +2 more
doaj +1 more source
Study of highly fluorinated heterocyclic polymers for cryogenic bladder applications Final report, 15 Oct. 1968 - 15 Mar. 1970 [PDF]
Highly fluorinated heterocyclic polymers for cryogenic bladder ...
Fitzgerald, W. P., Jr., Sanders, B. Y.
core +1 more source
Synthesis and anti-Aphid Aphis gossypii (Glover) activity of some new quinoline derivatives [PDF]
A series of quinoline derivatives have been elaborated fromreaction of 2-(m- and p-acetylanilino)-quinolines 6a-b withaldehydes under Claisen-Schmidt conditions followed by cyclization with phenyl hydrazine and hydroxylamine.
El Kafafy, Abdel Kader +3 more
core
Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics [PDF]
The reactive dicarbonyl metabolite methylglyoxal (MG) is the precursor of the major quantitative advanced glycation endproducts (AGEs) in physiological systems - argininederived hydroimidazolones and deoxyguanosine-derived imidazopurinones.
Rabbani, Naila +2 more
core +1 more source
The Latest Advances in Mechanically Robust Self‐Healing Polyurea Based on Dynamic Chemistry
Solving the contradiction between strength, toughness, and self‐healing properties is extremely important to realize the breakthrough of polyurea applications. This review summarizes and discusses common strategies for the preparation of high‐performance and self‐healing polyurea materials based on dynamic chemistry, providing molecular‐level insights ...
Yujia Hao, Guangming Zhu
wiley +1 more source

