Results 111 to 120 of about 26,014 (255)

Identification of Salvia haenkei as gerosuppressant agent by using an integrated senescence-screening assay. [PDF]

, 2016
Cellular senescence is a stable cell cycle arrest that is the causative process of aging. The PI3K/AKT/mTOR pathway is implicated in the control of cellular senescence and inhibitors of this pathway have been successfully used for life span prolongation ...
Alimonti, A., Bisio, A., Brun, P., Chen, J., Cocetta, V., Dall'Acqua, S., Mancino, G., Matic, I., Mattei, M., Milanese, M., Montopoli, M., Revandkar, A.   +11 more
core   +2 more sources

Autophagy Activators Normalize Aberrant Tau Proteostasis and Rescue Synapses in Human Familial Alzheimer's Disease iPSC‐Derived Cortical Organoids

Advanced Science, EarlyView.
A new cerebrocortical organoid model using isogenic hiPSCs with familial Alzheimer's mutations recapitulates key AD features, including amyloid‐beta and phospho‐Tau aggregation, neuronal hyperexcitability, and synapse loss. Single‐cell RNA‐seq reveals aberrant pathways in excitatory and inhibitory neurons.
Sergio R. Labra, Jadon Compher, Akhil Prabhavalkar, Mireya Almaraz, Claudia Cedeño Kwong, Christine Baal, Maria Talantova, Nima Dolatabadi, Julian Piña‐Sanz, Yubo Wang, Leonard Yoon, Swagata Ghatak, Zi Gao, Yuting Zhang, Dorit Trudler, Lynee Massey, Wei Lin, Anthony Balistreri, Michael Bula, Nicholas J. Schork, Tony S. Mondala, Steven R. Head, Jeffery W. Kelly, Stuart A. Lipton   +23 more
wiley   +1 more source

Molecular Regulation of SASP in Cellular Senescence: Therapeutic Implications and Translational Challenges

Cells
Cellular senescence is a complex process that significantly contributes to the pathogenesis of various diseases, including cancer and neurodegenerative disorders.
Hubert Klepacki, Krystyna Kowalczuk, Natalia Łepkowska, Justyna Magdalena Hermanowicz   +3 more
doaj   +1 more source

Oncogenic senescence: a multi-functional perspective. [PDF]

, 2017
Cellular senescence is defined as an irreversible growth arrest with the acquisition of a distinctive secretome. The growth arrest is a potent anticancer mechanism whereas the secretome facilitates wound healing, tissue repair, and development.
Alimirah, Fatouma, Baker, Darren J, Campisi, Judith, Hildesheim, Jeffrey, van Deursen, Jan M   +4 more
core  

Inflammation and premature aging in advanced chronic kidney disease [PDF]

, 2017
Systemic inflammation in end-stage renal disease (ESRD) is an established risk factor for mortality and a catalyst for other complications which are related to a premature aging phenotype, including muscle wasting, vascular calcification and other forms ...
Casper G. Schalkwijk, Frank M. van der Sande, Jeroen P. Kooman, Kaysen GA, Len A. Usvyat, Marijke J. Dekker, Paul G. Shiels, Peter Kotanko, Peter Stenvinkel, Witko-Sarsat V   +9 more
core   +1 more source

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

Recent advances in senescence-associated secretory phenotype and osteoporosis

Heliyon
The worldwide elderly population is on the rise, and aging is a major osteoporosis risk factor. Senescent cells accumulation can have a detrimental effect the body as we age.
Haonan Fan, Zhi Qiao, Jitian Li, Guowei Shang, Chunfeng Shang, Songfeng Chen, Zikuan Leng, Huifang Su, Hongwei Kou, Hongjian Liu   +9 more
doaj   +1 more source

Role of immune cells in the removal of deleterious senescent cells

Immunity & Ageing, 2020
Cellular senescence is an essentially irreversible arrest of cell proliferation coupled to a complex senescence-associated secretory phenotype (SASP).
Abhijit Kale, Amit Sharma, Alexandra Stolzing, Pierre-Yves Desprez, Judith Campisi   +4 more
doaj   +1 more source

CELL BIOLOGY. GATA get a hold on senescence. [PDF]

, 2015
A transcription factor's abundance connects autophagy to cellular senescence and a secretory phenotype [Also see Research Article by Kang et al.
Cassidy, Liam D, Narita, Masashi
core  

Implications of Cellular Aging in Cardiac Reprogramming [PDF]

, 2018
Aging is characterized by a chronic functional decline of organ systems which leads to tissue dysfunction over time, representing a risk factor for diseases development, including cardiovascular.
Passaro, Fabiana, Testa, Gianluca
core   +1 more source