Results 141 to 150 of about 17,888 (258)

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Osteoporosis and Periodontitis: Two‐Way Epidemiological and Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review investigates the main mechanistic pathways connecting local periodontitis to systemic osteoporosis. Seven interconnected mechanisms are identified. ABSTRACT Osteoporosis and periodontitis are highly prevalent, chronic inflammatory diseases that constitute a major global health burden.
Jia Chang, Geeta Madhuri Bhuvanagiri, Megan Dulkanchainun, Cunyu Wang   +3 more
wiley   +1 more source

KMT2A regulates the autophagy-GATA4 axis through METTL3-mediated m6A modification of ATG4a to promote NPCs senescence and IVDD progression

Bone Research
Intervertebral disc degeneration (IVDD), a disease associated with ageing, is characterised by a notable increase in senescent nucleus pulposus cells (NPCs) as IVDD progresses.
Ouqiang Wu, Yuxin Jin, Zhiguang Zhang, Hao Zhou, Wenbin Xu, Linjie Chen, Morgan Jones, Kenny Yat Hong Kwan, Jianyuan Gao, Kai Zhang, Xiaofei Cheng, Qizhu Chen, Xinzhou Wang, Yan Michael Li, Zhenyu Guo, Jing Sun, Zhihua Chen, Bin Wang, Xiangyang Wang, Shuying Shen, Aimin Wu   +20 more
doaj   +1 more source

Regulation of the Pro-Tumorigenic Senescence-Associated Secretory Phenotype

, 2017
Tumorigenesis results from the convergence of cell autonomous mutations and corresponding stromal changes that promote tumor cell growth. Mutations and stromal changes both accumulate with age and together account for the dramatic increase in cancer ...
Flanagan, Kevin
core   +1 more source

Bone biology in aging periodontal and peri‐implant tissues

Periodontology 2000, EarlyView.
Abstract Background Periodontal disease is an age‐related chronic inflammatory condition leading to tooth loss. Dental implants are an option for replacement of lost teeth in older adults. However, age‐related changes to alveolar bone may have pathological implications for its role in supporting the dentition and dental implants.
Dalia Rasheed Issa, Giuseppe Intini, Daniel Clark   +2 more
wiley   +1 more source

Cellular senescence in cancer: molecular mechanisms and therapeutic targets

MedComm
Aging exhibits several hallmarks in common with cancer, such as cellular senescence, dysbiosis, inflammation, genomic instability, and epigenetic changes.
Ping Jin, Xirui Duan, Lei Li, Ping Zhou, Cheng‐Gang Zou, Ke Xie   +5 more
doaj   +1 more source

Senescence-associated secretory phenotype regulated by mTOR pathway in senescent cells

Senescence is a state of a cell characterized by permanent cell cycle arrest, growth of the cell, and other phenotypic changes, including proinflammatory secretome.
Maslyaeva, Sofya
core  

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Conquering aging-related immunosenescence and tumor immune escape

Frontiers in Immunology
With global population aging, senescence has emerged as a key driver of tumorigenesis. Aging-associated molecular changes, including DNA damage, telomere shortening, and epigenetic dysregulation, increase malignancy, while immunosenescence and the ...
Shanshan Zhang, Shanshan Zhang, Bo Yang, Mingyi Xu, Mingyi Xu, Mingyi Xu, Ying Bing, Ying Bing, Ying Bing, Jiwang Zhang, Yuanxin Wang, Yuanxin Wang, Chaohui Zheng, Gang Zhang, Leisheng Zhang, Leisheng Zhang, Leisheng Zhang   +16 more
doaj   +1 more source

Understanding exosomes in facial esthetics and skin aging

Periodontology 2000, EarlyView.
Abstract Background Skin aging is a multifactorial process mediated by intrinsic (genetic and metabolic) and extrinsic (environmental) factors leading to functional and structural deterioration, including wrinkles, loss of collagen and elastin, as well as various pigmentation disorders.
Richard J. Miron, Catherine Davies, Anton Sculean, Paras Ahmad   +3 more
wiley   +1 more source