Results 141 to 150 of about 8,456,945 (252)
Cellular senescence in cancer: molecular mechanisms and therapeutic targets
MedCommAging exhibits several hallmarks in common with cancer, such as cellular senescence, dysbiosis, inflammation, genomic instability, and epigenetic changes.
Ping Jin +5 more
doaj +1 more source
Phloridzin Mitigates Aging‐Associated Periodontitis by Restraining Inflammatory Cell Death
Journal of Periodontal Research, EarlyView.Phloridzin attenuated oxidative stressinduced senescence, inflammatory responses, and osteogenic dysfunction in HPDLCs. In an aging‐associated experimental periodontitis model, phloridzin alleviated alveolar bone loss, suggesting its potential to maintain periodontal tissue integrity under aging‐related inflammatory conditions.
Da Eun Lee +2 more
wiley +1 more source
Bone ResearchIntervertebral disc degeneration (IVDD), a disease associated with ageing, is characterised by a notable increase in senescent nucleus pulposus cells (NPCs) as IVDD progresses.
Ouqiang Wu +20 more
doaj +1 more source
Orthopaedic Surgery, EarlyView.This article outlines a paradigm shift in OA therapeutics, OA as a systemic disease of joint microenvironment imbalance. It synthesizes advances in targeting key pathological hubs—immune, metabolic, and senescent—and details novel regenerative strategies using engineered biomaterials and exosomes.
Yongbiao Meng, Shenghua Wu, Quanchun Liu
wiley +1 more source
Bone biology in aging periodontal and peri‐implant tissues
Periodontology 2000, EarlyView.Abstract Background Periodontal disease is an age‐related chronic inflammatory condition leading to tooth loss. Dental implants are an option for replacement of lost teeth in older adults. However, age‐related changes to alveolar bone may have pathological implications for its role in supporting the dentition and dental implants.
Dalia Rasheed Issa +2 more
wiley +1 more source
Senescence-associated secretory phenotype regulated by mTOR pathway in senescent cells
Senescence is a state of a cell characterized by permanent cell cycle arrest, growth of the cell, and other phenotypic changes, including proinflammatory secretome.
Maslyaeva, Sofya
core
Periodontology 2000, EarlyView.Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng +4 more
wiley +1 more source
Understanding exosomes in facial esthetics and skin aging
Periodontology 2000, EarlyView.Abstract Background Skin aging is a multifactorial process mediated by intrinsic (genetic and metabolic) and extrinsic (environmental) factors leading to functional and structural deterioration, including wrinkles, loss of collagen and elastin, as well as various pigmentation disorders.
Richard J. Miron +3 more
wiley +1 more source
Understanding extracellular vesicles in antiaging
Periodontology 2000, EarlyView.Abstract Background Aging is a multifactorial process marked by gradual cellular dysregulation, regulated by hallmarks, including genomic instability, mitochondrial dysregulation, and chronic inflammation. Extracellular vesicles (EVs), especially exosomes, have emerged as pivotal mediators of cell‐to‐cell communication with potential roles in both ...
Paras Ahmad +3 more
wiley +1 more source
Periodontitis and metabolic dysfunction‐associated steatotic liver disease
Periodontology 2000, EarlyView.Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon +6 more
wiley +1 more source