Results 151 to 160 of about 10,262,985 (255)

Selective elimination of amyloid-β–induced senescent neuroblastoma cells by Moringa oleifera leaf extract

Scientific Reports
Accumulation of senescent cells (SnCs) in the ageing brain contributes to Alzheimer’s disease (AD) progression by secreting a senescence-associated secretory phenotype (SASP) that exacerbates neuroinflammation and neurodegeneration. Senolytic agents that
Nur Irlia Sofea Mohammad Zamani, Hamizah Shahirah Hamezah, Ahmed Mediani, Mizanurfakhri Ghazali, Muhammad Zulfiqah Sadikan, Faidruz Azura Jam   +5 more
doaj   +1 more source

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

The FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah, Grace Filbertine, Lucy Gill, Asangaedem Akpan, Marie M. Phelan, Helen Louise Wright   +5 more
wiley   +1 more source

Integrated chemical profiling, transcriptomics and functional validation elucidate the multifunctional benefits of a triple‐ferment filtrate complex for skin aging intervention

International Journal of Cosmetic Science, EarlyView.
Integrated chemical profiling, transcriptomics and functional validation reveal the multifunctional benefits of a triple‐ferment filtrate complex for skin aging intervention. Abstract Objective Skin aging is driven by interconnected hallmarks including oxidative stress and chronic low‐grade inflammation, cellular senescence, impaired epidermal function
Ping Gao, Xue Xiao, Hong Zhang, Fengjuan Tu, Xuelan Gu   +4 more
wiley   +1 more source

Proteostasis in the regulation of pancreatic islet cell plasticity

Journal of Diabetes Investigation, EarlyView.
Adaptive proteostasis integrates protein synthesis, folding, trafficking, and degradation through ISR, UPR, ER stress responses, autophagy, and proteasomal degradation. In pancreatic islet cells, this coordinated network preserves protein quality, secretory function, proliferation, and survival, enabling adaptation to metabolic stress and aging while ...
Jun Shirakawa
wiley   +1 more source

From cell senescence to age-related diseases: differential mechanisms of action of senescence-associated secretory phenotypes. [PDF]

, 2015
Cellular senescence is a process by which cells enter a state of permanent cell cycle arrest. It is commonly believed to underlie organismal aging and age-associated diseases.
Byun, HO, Kim, JM, Lee, YK, Yoon, G
core  

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Sabine Elisabeth Groeger, Yuxi Zhou, Jiawen Yong, Lei Wang, Sabine Ruf, Joerg Meyle   +5 more
wiley   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Mitochondrial Dysfunction as a Context-Dependent Driver and Amplifier of the SASP: Targeting the mtDNA-cGAS-STING Axis for Next-Generation Senotherapeutics. [PDF]

J Cell Mol Med
ABSTRACT Cellular senescence combines stable cell‐cycle arrest with mitochondrial and innate immune remodelling that shapes the senescence‐associated secretory phenotype (SASP). This narrative review evaluates mitochondrial dysfunction as a context‐dependent initiator or amplifier of senescence and examines mitochondrial DNA (mtDNA) sensing through ...
Hama HK, Hama MA, Zorab MM, Gholami A, Al-Farga AM.   +4 more
europepmc   +2 more sources

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

Osteoporosis and Periodontitis: Two‐Way Epidemiological and Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review investigates the main mechanistic pathways connecting local periodontitis to systemic osteoporosis. Seven interconnected mechanisms are identified. ABSTRACT Osteoporosis and periodontitis are highly prevalent, chronic inflammatory diseases that constitute a major global health burden.
Jia Chang, Geeta Madhuri Bhuvanagiri, Megan Dulkanchainun, Cunyu Wang   +3 more
wiley   +1 more source