Results 171 to 180 of about 10,262,985 (255)

Born early, age fast: Consequences of premature birth on chronic disease and accelerated ageing

The Journal of Physiology, EarlyView.
Abstract figure legend ELGANs are exposed to several postnatal pro‐oxidant stressors, including ambient and supplemental oxygen, mechanical ventilation, infections, hyperalimentation, excessive glucocorticoids and intermittent hypoxia. Since endogenous antioxidant defences are underdeveloped, this imbalance promotes oxidative stress and inflammation ...
Estelle B. Gauda, Julijana Ivanovska, Dwayne Mascarenhas, Jeffrey Antwi, Atefeh Mohammadi, Bonny Jasani   +5 more
wiley   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Correction to: Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP). [PDF]

Biogerontology, 2019
Rolt A, Nair A, Cox LS.
europepmc   +1 more source

IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways. [PDF]

Cell Commun Signal
Siraj Y, Aprile D, Alessio N, Peluso G, Di Bernardo G, Galderisi U.   +5 more
europepmc   +1 more source

Radiation‐Induced Skin Injury in Cancer Radiotherapy: From Mechanisms to Management

Advanced Oncology, Volume 1, Issue 1, December 2026.
Radiation‐induced skin injuries (RISI) remain a significant challenge faced by cancer patients receiving radiotherapy (RT). This perspective article examines the pathophysiology of RISI and evaluates the currently existing and emerging therapeutic strategies, including stem cell‐derived exosomes and advanced hydrogels.
Zeynep Meral Toutoungi, Nukhet Aykin‐Burns, Jingyi Chen, Younghye Song   +3 more
wiley   +1 more source

Stemonine Alleviates UVB‐Induced Keratinocyte Senescence by Activating SIRT3

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 11, November 2026.
Stemonine, a natural alkaloid, protects human HaCaT keratinocytes against UVB‐induced skin senescence. Stemonine attenuated oxidative stress, mitochondrial dysfunction, DNA damage, and key senescence markers. It functioned by upregulating the expression and activity of SIRT3.
Kun Chen, Xudong Yan, Guixiang You, Mingyang Li, Chen Chen, Xiaolan Yu, Jiyi Xia   +6 more
wiley   +1 more source

Leptin Neutralization Attenuates Inflammaging in Endothelial and Immune Cell Models

MedComm, Volume 7, Issue 11, November 2026.
Multiple mechanisms including senescent cell accumulation, metabolic and endotoxin‐driven stimulation of immune and endothelial cells contribute to inflammaging, the chronic low‐grade inflammatory status underlying age‐related diseases. Blocking leptin signaling in experimental models of inflammaging blunts inflammation in a model‐specific manner while
Valeria Pellegrini, Rosalba La Grotta, Alessia Metallo, Francesca Carreras, Chiara Frigé, Giulia Matacchione, Angelica Giuliani, Jacopo Sabbatinelli, Fabiola Olivieri, Francesca Rispoli, Lorenzo Drago, Cesare Celeste Berra, Raffaele Marfella, Giuseppe Paolisso, Giuseppe Matarese, Claudio Procaccini, Ilaria Spatocco, Giorgia Mele, Paola de Candia, Antonio Ceriello, Francesco Prattichizzo   +20 more
wiley   +1 more source

Arsenite exposure induces premature senescence and senescence-associated secretory phenotype (SASP) in human hepatocyte-derived cell line Huh-7. [PDF]

Environ Health Prev Med
Okamura K, Sato M, Suzuki T, Nohara K.
europepmc   +1 more source

Microbial and Metabolic Correlates of Endometrial Dysfunction in Polycystic Ovary Syndrome: A Translational Study

BJOG: An International Journal of Obstetrics &Gynaecology, Volume 133, Issue 12, Page 2092-2102, November 2026.
ABSTRACT Objective Women with polycystic ovary syndrome (PCOS) exhibit a substantially increased risk of miscarriage, yet the underlying mechanisms remain inadequately understood. This study aimed to investigate whether specific gut microbial dysbiosis and metabolic disturbance are associated with and may potentially contribute to endometrial ...
Mengyu Jing, Xi Chen, Meiyan Jiang, Huiya Fang, Xiaoming Zhu, Xuejing Jin, Yonghui Jiao, Ningning Hou, Weiwei Gong, Aixia Liu   +9 more
wiley   +1 more source

Senescence in head and neck squamous cell carcinoma: relationship between senescence-associated secretory phenotype (SASP) mRNA expression level and clinicopathological features. [PDF]

Clin Transl Oncol
Ostrowska K, Niewinski P, Piotrowski I, Ostapowicz J, Koczot S, Suchorska WM, Golusiński P, Masternak MM, Golusiński W.   +8 more
europepmc   +1 more source