Results 181 to 190 of about 8,456,945 (252)

Senescence-associated secretory phenotype (SASPs) regulation in estradiol-induced thymic involution

Annual Meeting of the Japanese Society of Toxicology
RAZALI, Nurhananibinti, NAKAYAMA, Kei, HASEGAWA, Hiroshi   +2 more
openaire   +1 more source

Surviving Fibroblasts After Treatment With Mitomycin C Exhibit SASP‐Like Phenotype After Glaucoma Filtration Surgery

Aging Cell, Volume 25, Issue 9, September 2026.
Transcriptomic analysis using a rabbit glaucoma filtration surgery model, combined with in vitro experiments on human conjunctival fibroblasts, demonstrates that mitomycin C induces a senescence‐associated secretory phenotype (SASP)‐like state. These SASP‐like fibroblasts were selectively eliminated by the specific senolytic agent, highlighting their ...
Akitoshi Kimura, Tomokazu Fujimoto, Satoshi Iraha, Kei‐Ichiro Yasunaga, Miyuki Inoue‐Mochita, Naofumi Funagura, Shunsuke Tanigawa, Daisuke Kurotaki, Tomoaki Koga, Fumika Watanabe‐Kitamura, Utako Tsutsumi‐Kuroda, Mitsuyoshi Nakao, Toshihiro Inoue   +12 more
wiley   +1 more source

hTERT Immortalization Stabilizes Human Umbilical Cord MSCs and Maintains Their Small Extracellular Vesicles With Preserved Immunomodulatory Activity and Primordial Follicle‐Activating Capacity

Aging Cell, Volume 25, Issue 9, September 2026.
hTERT immortalization stabilizes hUCMSC‐derived sEV function by alleviating cellular senescence and preserving young‐like cargo profiles. H11‐sEVs retain immunomodulatory activity, primordial follicle‐activating capacity, and ovarian protective effects.
Yating Chen, Wei Liu, Ying Tian, Xinyu Wang, Haonan Fan, Mingyu Yang, Feiyang Diao, Jing Li   +7 more
wiley   +1 more source

The double-edged sword of SASP in breast cancer: from tumor suppression to progression and therapy resistance. [PDF]

Front Oncol
Gao X, Zhang Y, Sun Y, Xu T.
europepmc   +1 more source

SIRT1 Silences L1 Retrotransposons by Stabilizing Heterochromatin‐Modifying Complexes

Aging Cell, Volume 25, Issue 9, September 2026.
SIRT1 binds the LINE‐1 5′‐UTR and recruits the heterochromatin modifiers Lamin B1 and KAP1 to maintain H3K9me3 levels, thereby suppressing LINE‐1 retrotransposition. SIRT1 deficiency enhances LINE‐1 transcription, leading to upregulation of senescence‐associated secretory phenotype factors, activation of the cGAS‐STING pathway, and consequent cellular ...
Xiaona Wang, Tianbo Li, Huanyin Tang, Meng Xiao Liu, Qinghua Peng, Xiao Huang, Zhiyong Mao, Ying Jiang, Anke Geng   +8 more
wiley   +1 more source

Senescent immune cells, inflammaging, and bone loss: therapeutic potential and translational challenges of senolytics in osteoporosis. [PDF]

Front Endocrinol (Lausanne)
Zhu M, Zhang J, Fang H, Cai K, Wu Q, Gao C, Wang Y, Chen J.   +7 more
europepmc   +1 more source

Growth Hormone Receptor Antagonism Extends Lifespan

Aging Cell, Volume 25, Issue 9, September 2026.
This study provides proof of concept that GH antagonism in GH‐producing mice extends lifespan, supporting further investigation of GH antagonists as potential anti‐aging interventions in animals and humans. ABSTRACT Interventions that disrupt growth hormone (GH) action are recognized as some of the most potent methods for extending lifespan ...
Edward O. List, Darlene E. Berryman, Grace S. Lach, Delaney F. Minto, Keeley Weese, John J. Kopchick   +5 more
wiley   +1 more source

Insights Into the Interplay Between the Senescent Cells and Immune Cells

Aging Cell, Volume 25, Issue 9, September 2026.
Kidney aging is associated with increased proximal tubular senescence and leukocyte infiltration. Senolytic treatment reduces senescent cell burden and overall immune cell infiltration. However, macrophages remain enriched around residual senescent cells.
Martin Jaros, Marco Schmidt, Lavinia Neubert, Jan‐Christopher Kamp, Sibylle von Vietinghoff, Jan Hinrich Bräsen, Roland Schmitt, Anette Melk   +7 more
wiley   +1 more source

The vicious cycle of SASP and inflammaging promotes aging and age-related diseases. [PDF]

Commun Biol
Liu Q, Zheng Y, Sun C.
europepmc   +1 more source

NAD+ Metabolic Reprogramming Drives CD8+ T Cells Senescence and Exacerbates Ulcerative Colitis

Aging Cell, Volume 25, Issue 9, September 2026.
Nicotinamide adenine dinucleotide (NAD+) depletion induces mitochondrial dysfunction and cytosolic mtDNA leakage in CD8+ T cells, activating the cGAS‐STING pathway and promoting a senescence‐associated secretory phenotype (SASP). The resulting pro‐inflammatory CD8+ T cells release IFN‐γ and TNF‐α, disrupt the intestinal epithelial barrier, and ...
Maolin Ye, Qi Zhou, Mingjia Kong, Suhan Zhao, Lingxi Lin, Lirong Chen, Jianghong Yu, Feifei Luo, Jie Liu, Jun Zhang   +9 more
wiley   +1 more source