Results 181 to 190 of about 10,262,985 (255)

Cellular Senescence Dysregulates Antiviral Interferon Responses in Idiopathic Pulmonary Fibrosis

Aging Cell, Volume 25, Issue 11, November 2026.
Senescent idiopathic pulmonary fibroblasts (IPF) lung fibroblasts are transcriptomically uncoupled from a functional response to virus relative to healthy (HLF) lung fibroblasts. HLF lung fibroblasts require viral effectors STAT1 or IRF3 to enact a viral response while IPF lung fibroblasts do not rely on these axes in response to virus.
Jun‐Wei B. Hughes, Yasmina Reisser, Franziska Hornung, Tyler A. U. Hilsabeck, Fiona Senchyna, Ana L. Coelho, Tsung‐Che Ho, Kevin Schneider, David Furman, Cory M. Hogaboam, Claude Jourdan Le Saux, Pierre‐Yves Desprez, Stefanie Deinhardt‐Emmer   +12 more
wiley   +1 more source

Alterations in the Immune‐Fibrotic Axis Are Spatially Localized in the Aging Heart

Aging Cell, Volume 25, Issue 11, November 2026.
Aging does not affect the heart uniformly: unique changes in immune cells (macrophages) and scar‐forming cells (fibroblasts) first appear in the valves and aorta and spread into the heart muscle with age. Aged fibroblasts also develop features shared with human heart fibroblasts that may contribute to declining cardiovascular health.
Aleksandra Aljakna Khan, Amalia Sintou, Yue Zhao, Antonios Somarakis, Harshpreet Chandok, Juliana Alcoforado Diniz, Ramalakshmi Ramasamy, Gretchen T. Clark, Leon Frommer, Sikander Hayat, Brian S. White, Paul Robson, Ron Korstanje, J. Matthew Mahoney, Nadia A. Rosenthal   +14 more
wiley   +1 more source

Senescent Mesenchymal Stromal Cells Drive Stem Cell Aging Through Dysregulated Chemokine Synthesis

Aging Cell, Volume 25, Issue 11, November 2026.
Senescent MSCs do more than fuel inflammaging: they disrupt the chemokine signals that maintain stem cell function. We propose that restoring this signaling balance through senolytics, senomorphics, or MSC rejuvenation may preserve regenerative capacity during aging. ABSTRACT Aging is accompanied by a progressive decline in tissue regenerative capacity,
Shaianne N. Stein, Lorena R. Braid
wiley   +1 more source

Tree Shrew as an Emerging Model for Aging Research: Characterization of Senescence and Therapeutic Interventions

Aging Cell, Volume 25, Issue 11, November 2026.
Compared with mouse cells, tree shrew fibroblasts more faithfully recapitulate the hallmarks of human cellular senescence. In vivo, aged tree shrews exhibit transcriptomic signatures of aging across multiple organs that closely mirror those observed in humans.
Qiuni Luo, Wenxian Xiao, Xin Dong, Ayesha Nisar, Yuhua Ma, Xiang Lai, Raoxian Bai, Meiting Zi, Qi Geng, Qingyu Zhang, Cheng Zhang, Qiong Wang, Naheemat Modupeola Gold, Zhen Zhou, Li Hu, Ao Zhang, Qinghua Zeng, Jing Liu, Sawar Khan, Longbao Lv, Yonghan He   +20 more
wiley   +1 more source

The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on metastatic prostatic cancer cells. [PDF]

Aging (Albany NY), 2019
Alessio N, Aprile D, Squillaro T, Di Bernardo G, Finicelli M, Melone MA, Peluso G, Galderisi U.   +7 more
europepmc   +1 more source

FGF13 Alleviates the Aging Process in Mice by Regulating Astrocyte Function in the Medial Prefrontal Cortex via Phafin2 Signaling Pathway

Aging Cell, Volume 25, Issue 11, November 2026.
FGF13 is significantly downregulated in the aging brain, particularly in cortical astrocytes within the medial prefrontal cortex. Genetic knockdown of FGF13 in astrocytes accelerates aging phenotypes and impairs neurological function in mice, while its overexpression effectively delays cognitive decline.
Rui Zheng, Zheng Tu, Yang Fang, Caixiang Zhuang, Yuchao Zhang, Yibo Ying, Zhiyi Feng, Ziyang Jin, Yanyan Zheng, Zhouguang Wang   +9 more
wiley   +1 more source

Histone Modifications at the Intersection of Aging, Neuroinflammation and Metabolism in Alzheimer's Disease

Aging Cell, Volume 25, Issue 11, November 2026.
This review examines how histone modifications integrate aging, metabolic dysfunction and neuroinflammation to shape persistent, cell‐type‐specific chromatin states in Alzheimer's disease. By distinguishing causal regulation from association through perturbation, persistence and reversibility, it highlights metabolic–epigenetic feedback loops and ...
Junyi Liang, Huawen Cao, Xiumin Ren, Nan Sha, Xueqing Han, Ling Jiang, Bin Liu, Weiming Zhao   +7 more
wiley   +1 more source

A Novel Peptide Targeting the USP25–SIRT1 Interaction Activates SIRT1 to Suppress Cell Senescence

Aging Cell, Volume 25, Issue 11, November 2026.
USP25‐mediated K63‐linked deubiquitination of SIRT1 at K506 and K513 suppresses its activity to promote senescence. These findings unveil a novel aging regulatory axis and identify a peptide targeting the USP25–SIRT1 interaction for anti‐senescence therapeutic intervention.
YuJuan Zhou, Xinshu Wang, Jiyuan Zhang, Hanqiong Qiang, Xinru Zhao, Jingyi Luo, Yanjun Ji, Jiakai Yao, Linhui Zhai, Tingting Zhang, Ke Li, Yuping Chen, Jian Yuan, Lei Li, Yunhui Li   +14 more
wiley   +1 more source

TOP2A Maintains Heterochromatin Stability by Sustaining LMNB1 Expression to Counteract Senescence

Aging Cell, Volume 25, Issue 11, November 2026.
Depletion of TOP2A accelerates MSC senescence and disrupts heterochromatin integrity. TOP2A directly regulates LMNB1 expression to maintain MSC nuclear integrity and epigenomic stability. Overexpression of TOP2A counteracts MSC senescence through Lamin B1‐mediated chromatin reorganization and epigenomic stabilization.
Ke Cheng, Yaru Wang, Yueyuan Pan, Wenjun Zhang, Denghong Yu, Qi Zhou, Zhiqian Zhong, Ruyi Mei, Chaoliang Xu, Ayidana Hayierhan, Yumei Ma, Yien Xu, Qingdong Xie, Pingnan Sun, Junzhi Zhou, Xiaoling Zhou   +15 more
wiley   +1 more source

Role of Sirtuins in the Hallmarks of Skin Aging

Aging Cell, Volume 25, Issue 11, November 2026.
In the skin, sirtuins support the integrity of the epidermis and dermis and protect the skin from environmental insults by maintaining cellular homeostasis. Sirtuins decline with chronological age, contributing to the biological hallmarks of aging, with increasing evidence emerging of their specific roles in skin aging.
Rishabh Kala, Antonella Rella, Whitby Eagle, Earl Goyarts, Jian Cao, Binwei Deng, Kelly Dong, Chloe Schmit, Matthew Cappock, Krystle Corallo, Jacqueline Trivero   +10 more
wiley   +1 more source