Results 181 to 190 of about 21,370 (250)

The Role of Piezo 1 in the Study of Intervertebral Disc Degeneration: Phenotype, Mechanism and Treatment

Orthopaedic Surgery, Volume 18, Issue 5, Page 897-914, May 2026.
As the key mechanotransducer in IVDD, Piezo1 orchestrates region‐specific degeneration across NP (senescence/ECM dysregulation), AF (apoptosis), and CEP (inflammation). This review integrates mechanistic pathways and assesses multimodal therapeutic targeting (pharmacologic/genetic/nutritional) to restore disc homeostasis.
Guangye Li, Chaoqun Feng, Haoyun Huang, Junwen Deng, Fei Yang, Rigao Chen   +5 more
wiley   +1 more source

Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP). [PDF]

Aging (Albany NY)
Bar S, Hilsabeck TAU, Pattavina B, López-Domínguez JA, Basisty N, Bons J, Watson M, Schilling B, Campisi J, Kapahi P, Sharma A.   +10 more
europepmc   +1 more source

Multi‐Omics and Machine Learning‐Uncovered FLT1‐Mediated Epithelial‐Endothelial Crosstalk in Cellular Senescence Driving Clear Cell Renal Cell Carcinoma Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
This study integrates multi‐omics data and machine learning to reveal FLT1 as a central mediator of epithelial‐endothelial crosstalk in clear cell renal cell carcinoma (ccRCC). We demonstrate that FLT1‐associated signaling promotes a senescence‐enriched tumor microenvironment, driving malignant progression. Spatial and single‐cell analyses confirm FLT1
Mouyuan Sun, Huchao Mao, Yaxian Luo, Mei Yang, Zhixu He, Shuangyang Li, Zhichao Liu, Lianjie Peng, Quanjie Zhang, Jingyu Zhang, Yan Zhang   +10 more
wiley   +1 more source

p21 Knockdown as a Therapeutic Strategy for Focal Cartilage Injury Repair

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
Intraarticular injection of lentiviral p21 shRNA (targeting Cdkn1a) into murine knees with full‐thickness cartilage defects reduces chondrocyte senescence while enhancing matrix repair with minimal hepatic off‐target effects. ABSTRACT Focal articular cartilage defects lack intrinsic regenerative capacity and can progress to osteoarthritis as no ...
Leila Larijani, Aria Ahadzadeh Ardebili, Nini Ortiz Vales, Andreas T. Stürmer, Roman J. Krawetz   +4 more
wiley   +1 more source

IGFBP7 is a key component of the senescence-associated secretory phenotype (SASP) that induces senescence in healthy cells by modulating the insulin, IGF, and activin A pathways. [PDF]

Cell Commun Signal
Siraj Y, Aprile D, Alessio N, Peluso G, Di Bernardo G, Galderisi U.   +5 more
europepmc   +1 more source

Correction to: Optimisation of a screening platform for determining IL-6 inflammatory signalling in the senescence-associated secretory phenotype (SASP). [PDF]

Biogerontology, 2019
Rolt A, Nair A, Cox LS.
europepmc   +1 more source

The senescence-associated secretory phenotype (SASP) from mesenchymal stromal cells impairs growth of immortalized prostate cells but has no effect on metastatic prostatic cancer cells. [PDF]

Aging (Albany NY), 2019
Alessio N, Aprile D, Squillaro T, Di Bernardo G, Finicelli M, Melone MA, Peluso G, Galderisi U.   +7 more
europepmc   +1 more source

Arsenite exposure induces premature senescence and senescence-associated secretory phenotype (SASP) in human hepatocyte-derived cell line Huh-7. [PDF]

Environ Health Prev Med
Okamura K, Sato M, Suzuki T, Nohara K.
europepmc   +1 more source

Senescence in head and neck squamous cell carcinoma: relationship between senescence-associated secretory phenotype (SASP) mRNA expression level and clinicopathological features. [PDF]

Clin Transl Oncol
Ostrowska K, Niewinski P, Piotrowski I, Ostapowicz J, Koczot S, Suchorska WM, Golusiński P, Masternak MM, Golusiński W.   +8 more
europepmc   +1 more source

Arresting IPF Progression: EZY-1 Targets mTORC2 to Inhibit Senescence-Associated Secretory Phenotype (SASP)

Food Science and Human Wellness
Mingjin Tu, Huajun Yu, Lili Chen, Xiaoqin Huangd, Liuyan He, Rongrong Chen, Xilian Tang, Jun Wu, Haitao Zhang   +8 more
openaire   +1 more source