Senescence-associated secretory phenotype sasp

Results 191 to 200 of about 8,456,945 (252)

Transmembrane Protein PTCHD4 Is a Novel Regulator of Cellular Senescence and Age‐Related Pathologies

Aging Cell, Volume 25, Issue 9, September 2026.
PTCHD4 is induced by aging‐ and injury‐associated stresses and acts as a senescence‐associated transmembrane regulator. Through AKT activation, PTCHD4 promotes cellular senescence, SASP, functional decline, and pulmonary fibrosis, whereas PTCHD4 deficiency dampens AKT signaling and alleviates senescence‐associated pathological phenotypes.
Mingyue Wang +11 more
wiley +1 more source

Royal jelly suppresses senescence-associated secretory phenotype in senescent human epidermal keratinocytes. [PDF]

Mol Biol Rep
Nakagawa Y, Okamoto H, Okumura N.
europepmc +1 more source

Rethinking Senescence Hallmarks in the Brain: Lessons From Peripheral Tissues and Challenges in Defining Neuronal Senescence

Aging Cell, Volume 25, Issue 9, September 2026.
Neuronal senescence‐like states arise from convergent intrinsic and disease‐associated stressors and are linked to persistent dysfunction, SASP‐like signaling, and altered glial interactions. Because no single marker is definitive in post‐mitotic neurons, multimarker and context‐dependent frameworks are required to define their role in ...
Miraj Ud Din Momand, Kristina Macova, Dominika Fricova +2 more
wiley +1 more source

Mechanisms of Doxorubicin-Induced Cardiac Senescence and Potential Therapeutic Strategies. [PDF]

Biomolecules
Bai Y +7 more
europepmc +1 more source

Update on Non‐Biological and RNA‐Based Therapeutics in Chronic Inflammatory Diseases: Precision Medicine Through Small Molecules: An EAACI Position Paper

Allergy, Volume 81, Issue 9, Page 3039-3070, September 2026.
ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
Franziska Roth‐Walter +20 more
wiley +1 more source

Premature placental senescence in early-onset preeclampsia: syncytiotrophoblast SASP and the maternal syndrome. [PDF]

Front Public Health
Zhou M, Zhang S, Hong S.
europepmc +1 more source

Clinical Features of Cellular Senescence Pathways in Severe Asthma

Allergy, Volume 81, Issue 9, Page 3273-3285, September 2026.
In bronchial biopsies, SASP and p53 pathway enrichment scores are elevated in severe asthma versus non‐severe asthma and healthy controls. SASP enrichment is validated in the independent NOVA cohort. SASP enrichment is also elevated in nasal brushings of participants with nasal polyps, independently of asthma status.
Woo‐Jung Song +122 more
wiley +1 more source

Remodeling the Immune Landscape: How Obesity-Induced SASPs Create a Pro-Tumorigenic Niche. [PDF]

Curr Obes Rep
Abd El-Fattah EE, Ngai G, Mooney R, Aboody KS. +3 more
europepmc +1 more source

Low‐Dose Fisetin Supplementation and Its Association With Chronic Inflammation in Middle‐Aged and Older Adults: Study Protocol for a Triple‐Blind, Randomised, Placebo‐Controlled Trial

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 3, September 2026.
ABSTRACT Systemic chronic inflammation contributes to the development of many age‐related chronic diseases and represents a promising target for interventions aiming at promoting healthy aging. Fisetin is a naturally occurring flavonoid with anti‐inflammatory, antioxidant and senolytic effects in vitro and in animal models, but evidence from randomised
Juliette Tavenier +15 more
wiley +1 more source

Cellular senescence: the "hidden driver" in chronic inflammatory skin disorders. [PDF]

Immun Ageing
Liang H, Li J, Zhang K.
europepmc +1 more source

cellular senescence
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senescence-associated secretory phenotype

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