Results 201 to 210 of about 8,456,945 (252)

AMPK‐mediated prevention of vascular dysfunction with metformin: Experimental and population‐based evidence

British Journal of Pharmacology, Volume 183, Issue 17, Page 5389-5406, September 2026.
Angiotensin II induces vascular inflammation, senescence, extracellular matrix (ECM) degradation and endothelial dysfunction, thus impairing SK+/IK+ channel function and reducing endothelial‐dependent hyperpolarisation (EDH). Metformin activates AMPK, increasing SK+/IK+ channel function and restoring vasorelaxation.
Soroush Mohammadi Jouabadi, Annika A. Jüttner, Annique Claringbould, Rene de Vries, Ingrid M. Garrelds, Usha Musterd‐Bhaggoe, Bruno H. Stricker, Maryam Kavousi, A. H. Jan Danser, Fariba Ahmadizar, Anton J. M. Roks   +10 more
wiley   +1 more source

Fate Bifurcation of Cellular Senescence: Dynamic Regulation from Tumor Suppression to Recurrence Risk. [PDF]

Cells
Chen X, Liu H, Shu Q, Tang Y, Zhang J, Yu W, Li S.   +6 more
europepmc   +1 more source

Understanding and addressing resistance to IMiDs immunomodulatory compounds in multiple myeloma

The FEBS Journal, Volume 293, Issue 17, Page 5121-5139, September 2026.
IMiDs are pivotal in the treatment of multiple myeloma. Mechanisms of resistance comprise cell intrinsic and extrinsic pathways, involving tumour microenvironment, immune cell dysfunction, CRBN‐dependent and independent genetic drivers and epigenetic changes.
Maria‐Cynthia Fuentes‐Lacouture, Devi Nandana, Karthik Ramasamy, Anjan Thakurta   +3 more
wiley   +1 more source

Cellular senescence and inflammageing: from mechanisms to senotherapeutic interventions. [PDF]

Biogerontology
Chmielewski PP.
europepmc   +1 more source

Senescent Human Liver Endothelial Cells Mediate CD4+ T Cell Recruitment via ICOSL

Immunology, Volume 179, Issue 1, Page 149-160, September 2026.
In this study, we detect senescent endothelial cells within chronically diseased human liver tissues. Next, we develop a novel protocol for the induction of paracrine senescence in primary human liver endothelial cells and explore their functionality.
Daniel A. Patten, Amy Lumley, Alex L. Wilkinson, Ayla O’Keeffe, Kelvin Yin, Niranjan Shirgaonkar, Ran Gao, Ramanuj DasGupta, Matthew Hoare, Shishir Shetty   +9 more
wiley   +1 more source

Ferroptosis-Senescence Crosstalk in Sepsis-Associated Acute Lung Injury: Mechanisms and Therapeutic Opportunities. [PDF]

Biomedicines
Luo R, Chen Q, Wang J, Nie Z, Dan L, Xie S.   +5 more
europepmc   +1 more source

Naringenin as a Multifunctional Ingredient Targeting Pathways Associated With Skin Inflammaging: Preclinical and Clinical Evidence

Journal of Cosmetic Dermatology, Volume 25, Issue 9, September 2026.
ABSTRACT Background Inflammaging, a sustained state of low‐level inflammatory activity with age, is a driving factor in age‐related changes in skin structure, function, and appearance. By perturbing fundamental biological pathways, inflammaging is a relevant target in skincare and anti‐aging research.
Taylor Oswald, Zixuan Shao, Nicholas Brideau   +2 more
wiley   +1 more source

Hypothalamic Inflammaging: A Central Driver of Type 2 Diabetes Mellitus and Metabolic Disease in Aging. [PDF]

Diabetes Metab J
Lyoo SH, Kim KH, Kim KW.
europepmc   +1 more source

Effects of a Dietary Supplement on Systemic Aging Related Biomarkers and Skin Aging Outcomes in Middle‐Aged Women: In Vitro and Clinical Studies

Journal of Cosmetic Dermatology, Volume 25, Issue 9, September 2026.
ABSTRACT Background Interest in dietary supplements targeting both skin and biological aging biomarkers is rapidly growing, yet existing studies lack rigorous clinical validation of combined oral–topical regimens and concurrent assessment of skin and systemic biomarkers.
Jie‐Hua Chen, Liugang Ding, Pingping Lv, Wenzhi Li, Meiling Tai, Ran Yin, Yi Yu, Yunru Huang, Jinluan Zheng, Erman Wang, Huan Liu, Jiaojiao Fu, Hongjue Wang, Ruopan Huang, Jun Ma   +14 more
wiley   +1 more source

Cellular Senescence-Associated Gene Expression in Circulating CD4⁺, CD8⁺, CD19⁺ Lymphocytes of HNSCC Patients: Associations with Clinical Parameters. [PDF]

Cells
Ostrowska K, Niewinski P, Piotrowski I, Kubicka A, Ostapowicz J, Kozikowska J, Jazikowska A, Czochór K, Marchlewska J, Procyk D, Leporowska E, Suchorska WM, Yousefzadeh MJ, Masternak MM, Golusiński W.   +14 more
europepmc   +1 more source